WordNet

remove the bones from; "bone the turkey before roasting it" (同)debone
the porous calcified substance from which bones are made (同)osseous_tissue
consisting of or made up of bone; "a bony substance"; "the bony framework of the body"
a shade of white the color of bleached bones (同)ivory, pearl, off-white
rigid connective tissue that makes up the skeleton of vertebrates (同)os
having bones as specified; "his lanky long-boned body"
having had the bones removed; "a boneless rib roast"; "a boned (or deboned) fish" (同)deboned
the organic process in which the substance of some differentiated structure that has been produced by the body undergoes lysis and assimilation (同)reabsorption
a percussion instrument consisting of a pair of hollow pieces of wood or bone (usually held between the thumb and fingers) that are made to click together (as by Spanish dancers) in rhythm with the dance (同)castanets, clappers, finger cymbals
cell that functions in the breakdown and resorption of bone tissue

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1. ビスホスホネートの薬理学 pharmacology of bisphosphonates
2. 骨格の正常な発達および骨形成ならびに骨吸収の調節 normal skeletal development and regulation of bone formation and resorption
3. 骨転移の機序 mechanisms of bone metastases
4. 高カルシウム血症の治療 treatment of hypercalcemia
5. 進行癌患者における骨修飾薬による薬剤療法のリスク risks of therapy with bone modifying agents in patients with advanced malignancy

Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways.

Ma J1, Ma Y1, Liu X2, Chen S1, Liu C1, Qin A3, Fan S4.
The Biochemical journal.Biochem J.2015 Aug 1;469(3):399-408. doi: 10.1042/BJ20150151. Epub 2015 Jun 11.
Excessive osteoclast formation and bone resorption are key causes of osteoporosis. Natural compounds can serve as alternative therapeutic agents for the prevention and treatment of osteoporosis, and some natural compounds may have advantages over traditional drugs. In the present paper, we report th
PMID 26205493

Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model.

Shao H1, Shen J2, Wang M3, Cui J1, Wang Y1, Zhu S1, Zhang W4, Yang H1, Xu Y5, Geng D6.
Biomaterials.Biomaterials.2015 Aug;60:92-9. doi: 10.1016/j.biomaterials.2015.04.048. Epub 2015 May 15.
Periprosthetic osteolysis and subsequent aseptic loosening are common in implant failure, a complication with revision surgery being the only established treatment. Wear particle-induced inflammation and extensive osteoclastogenesis play critical roles in periprosthetic osteolysis. A recent approach
PMID 25985156

Choi SW1, Yeon JT2, Ryu BJ1, Kim KJ2, Moon SH1, Lee H3, Lee MS4, Lee SY5, Heo JC6, Park SJ7, Kim SH1.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.J Bone Miner Res.2015 Aug;30(8):1494-507. doi: 10.1002/jbmr.2468. Epub 2015 May 21.
Drug repositioning is a rational approach for expanding the use of existing drugs or candidate drugs to treat additional disorders. Here we investigated the possibility of using the anticancer p21-activated kinase 4 (PAK4)-targeted inhibitor PF-3758309 to treat osteoclast-mediated disorders. PAK4 wa
PMID 25640698

Polychlorinated biphenyl (118) activates osteoclasts and induces bone resorption in goldfish

Yachiguchi Koji,Matsumoto Noriko,Haga Yuki,Suzuki Motoharu,Matsumura Chisato,Tsurukawa Masahiro,Okuno Toshihiro,Nakano Takeshi,Kawabe Kimi,Kitamura Kei-ichiro,Toriba Akira,Hayakawa Kazuichi,Chowdhury Vishwajit S.,Endo Masato,Chiba Atsuhiko,Sekiguchi Toshio,Nakano Masaki,Tabuchi Yoshiaki,Kondo Takashi,Wada Shigehito,Mishima Hiroyuki,Hattori Atsuhiko,Suzuki Nobuo
Environmental Science and Pollution Research 21(10), 6365-6372, 2014-05
… To analyze the effect of polychlorinated biphenyl (PCB) 118 on fish bone metabolism, we examined osteoclastic and osteoblastic activities, as well as plasma calcium levels, in the scales of PCB (118)-injected goldfish. … At 1 and 2 days after PCB (118) injection (100 ng/g body weight), both osteoclastic and osteoblastic activities, and plasma calcium levels were measured. …
NAID 120005253213

Increased Prostaglandin E_2 Has a Positive Correlation with Plasma Calcium during Goldfish Reproduction

Suzuki Nobuo,Maruyama Yusuke,Nakano Masaki,Hattori Atsuhiko,Honda Masato,Shimasaki Yohei,Sekiguchi Toshio,Mishima Hiroyuki,Wada Shigehito,Srivastav Ajai K.,Hayakawa Kazuichi,Ohshima Yuji
Journal of the Faculty of Agriculture, Kyushu University 59(1), 97-101, 2014-02-29
… We recently demonstrated that prostaglandin E_2 (PG_2) increases osteoclastic activity and induces bone resorption in both in vitro and in vivo experiments using goldfish. … To clarify the Ca metabolism in fish reproduction, we examined plasma PGE_2 and Ca levels and measured tartrate–resistant acid phosphatase (TRAP) activities as an indicator of osteoclastic activity in goldfish. …
NAID 120005411069

Increased prostaglandin e2 has a positive correlation with plasma calcium during goldfish reproduction

Suzuki Nobuo,Maruyama Yusuke,Nakano Masaki,Hattori Atsuhiko,Honda Masato,Shimasaki Yohei,Sekiguchi Toshio,Mishima Hiroyuki,Wada Shigehito,Srivastav Ajai K.,Hayakawa Kazuichi,Oshima Yuji
Journal of the Faculty of Agriculture, Kyushu University 59(1), 97-101, 2014-02
… We recently demonstrated that prostaglandin E2 PG¿ increases osteoclastic activity and induces bone resorption in both in vitro and in vivo experiments using goldfish. … To clarify the Ca metabolism in fish reproduction, we examined plasma PGE2 and Ca levels and measured tartrate-resistant acid phosphatase (TRAP) activities as an indicator of osteoclastic activity in goldfish. …
NAID 120005435507