WordNet

the descendants of one individual; "his entire lineage has been warriors" (同)line, line of descent, descent, bloodline, blood_line, blood, pedigree, ancestry, origin, parentage, stemma, stock
cell that functions in the breakdown and resorption of bone tissue

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1. 悪性腫瘍の高カルシウム血症 hypercalcemia of malignancy
2. 骨パジェット病の臨床症状および診断 clinical manifestations and diagnosis of paget disease of bone
3. 乳癌からの骨転移マネージメントにおける破骨細胞阻害 osteoclast inhibition in the management of bone metastases from breast cancer
4. ステロイド誘発性骨粗鬆症の病因、臨床的特徴、および評価 pathogenesis clinical features and evaluation of glucocorticoid induced osteoporosis
5. 炎症性腸疾患における代謝性骨疾患 metabolic bone disease in inflammatory bowel disease

Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes.

Chia LY1, Walsh NC1, Martin TJ1, Sims NA2.
Bone.Bone.2015 Mar;72:34-42. doi: 10.1016/j.bone.2014.11.005. Epub 2014 Nov 15.
To define their gene expression and function, osteocytes are commonly isolated and purified by fluorescence-activated cell sorting (FACS) from mice expressing GFP directed by the dentin matrix protein 1 (Dmp1) promoter (DMP1-GFP). These cells express mRNA for osteocyte genes, including sclerostin (S
PMID 25460578

Wang Y1, Dong G2, Jeon HH3, Elazizi M2, La LB2, Hameedaldeen A2, Xiao E4, Tian C2, Alsadun S2, Choi Y5, Graves DT6.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Feb 18. pii: 1402211. [Epub ahead of print]
We have previously shown that the transcription factor FOXO1 is elevated in conditions with high levels of bone resorption. To investigate the role of FOXO1 in the formation of osteoclasts, we examined mice with lineage-specific deletion of FOXO1 in osteoclast precursors and by knockdown of FOXO1 wi
PMID 25694609

Dual Impact of Live Staphylococcus aureus on the Osteoclast Lineage, Leading to Increased Bone Resorption.

Trouillet-Assant S1, Gallet M2, Nauroy P2, Rasigade JP1, Flammier S1, Parroche P3, Marvel J3, Ferry T1, Vandenesch F1, Jurdic P2, Laurent F1.
The Journal of infectious diseases.J Infect Dis.2015 Feb 15;211(4):571-81. doi: 10.1093/infdis/jiu386. Epub 2014 Jul 8.
BACKGROUND: Bone and joint infection, mainly caused by Staphylococcus aureus, is associated with significant morbidity and mortality, characterized by severe inflammation and progressive bone destruction. Studies mostly focused on the interaction between S. aureus and osteoblasts, the bone matrix-fo
PMID 25006047

Promotion of osteoclast differentiation and activation in spite of impeded osteoblast-lineage differentiation under acidosis: Effects of acidosis on bone metabolism

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BioScience Trends 7(1), 33-41, 2013
… The acidosis that accompanies many diseases and pathological conditions can promote osteoclast formation and activation. … Acidosis mainly acts on the last phase of osteoclast formation to generate large osteoclasts and promote bone resorption. … TRPV4 channels appear to be, at least partly, implicated in acidosis-promoted large osteoclast formation. …
NAID 130004572583

Balanced Mineralization in the Arterial System : Possible Role of Osteoclastogenesis/Osteoblastogenesis in Abdominal Aortic Aneurysm and Stenotic Disease

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Circulation journal : official journal of the Japanese Circulation Society 76(12), 2732-2737, 2012-11-25
… Although previously understood as passive precipitation, evidence has accumulated to suggest that arterial calcification is the result of organized, regulated processes bearing many similarities to osteogenesis in bone, including the presence of subpopulations of arterial wall cells that retain osteoblastic lineage potential. … By contrast, osteoclast-like cells mediate the catabolic process of mineral resorption. …
NAID 10031126038

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Inflammation and Regeneration 31(5), 413-419, 2011
… Bone-resorbing osteoclasts develop from monocyte-macrophage lineage cells under the regulation of bone-forming osteoblasts. …
NAID 130004943807