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1. 嚢胞性線維症：実験的治療 cystic fibrosis investigational therapies
2. 幼児および小児における急性便秘の予防および治療 prevention and treatment of acute constipation in infants and children
3. 低ナトリウム血症患者におけるナトリウム欠乏の評価 estimation of the sodium deficit in patients with hyponatremia
4. 運動関連低ナトリウム血症 exercise associated hyponatremia
5. 急性腎障害（急性腎不全）における腎代替療法（透析）：代謝および血行動態に関する
考慮事項 renal replacement therapy dialysis in acute kidney injury acute renal failure metabolic and hemodynamic considerations

Preparation of pellets with controlled release of glucose as prevention of hypoglycaemia in paediatric patients.

Franc A1, Muselík J2, Sabadková D3, Neumann D4.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2015 Jul 30;75:72-80. doi: 10.1016/j.ejps.2015.03.007. Epub 2015 Mar 21.
Hypoglycaemic episodes represent serious and frequent complications of type 1 and 2 diabetes. Theoretically, the risk of hypoglycaemic states can be affected by a dosage form based on a food supplement containing a delayed release formulation of glucose. The release of glucose should compensate for
PMID 25805346

Maisel K1, Chattopadhyay S2, Moench T3, Hendrix C4, Cone R5, Ensign LM6, Hanes J7.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2015 Jul 10;209:280-7. doi: 10.1016/j.jconrel.2015.04.040. Epub 2015 Apr 30.
Delivering drugs to the colorectum by enema has advantages for treating or preventing both local and systemic diseases. However, the properties of the enema itself are not typically exploited for improving drug delivery. Sodium ions are actively pumped out of the lumen of the colon, which is followe
PMID 25937321

Identification and Molecular Mechanisms of the Rapid Tonicity-induced Relocalization of the Aquaporin 4 Channel.

Kitchen P1, Day RE2, Taylor LH1, Salman MM2, Bill RM3, Conner MT4, Conner AC5.
The Journal of biological chemistry.J Biol Chem.2015 Jul 3;290(27):16873-81. doi: 10.1074/jbc.M115.646034. Epub 2015 May 26.
The aquaporin family of integral membrane proteins is composed of channels that mediate cellular water flow. Aquaporin 4 (AQP4) is highly expressed in the glial cells of the central nervous system and facilitates the osmotically driven pathological brain swelling associated with stroke and traumatic
PMID 26013827

Hereditary Spherocytosis in a Middle-aged Man Complicated with Common Bile Duct Stones

Sawahara Hiroaki,Iwamuro Masaya,Harada Ryo,Yoshioka Masao,Niguma Takefumi,Mimura Tetsushige,Yamamoto Kazuhide
Internal Medicine 54(12), 1509-1512, 2015
… Hereditary spherocytosis is the most common form of hemolytic anemia and is characterized by spherical, osmotically fragile erythrocytes that are selectively trapped by the spleen. …
NAID 130005075955

高梨裕典,小山真,高橋毅,閨谷洋
日本呼吸器外科学会雑誌 29(4), 527-530, 2015
我々は，気胸患者に対する50%ブドウ糖液を用いた胸膜癒着術により脱水を来し，虚血性腸炎に至った症例を経験したので報告する．症例は97歳男性，呼吸苦を主訴に救急外来を受診し，胸部単純X線で右気胸を認めドレナージを実施した．5日間のドレナージで気漏が停止せず，50%ブドウ糖液400 mlを注入し胸膜癒着術を施行した．注入から翌日までの10時間で胸腔ドレーンより約1960 mlの排液を認め，脱水による腎 …
NAID 130005072326

Gastric Emptying of a Carbohydrate-electrolyte Solution in Healthy Volunteers Depends on Osmotically Active Particles

Kim Chol,Okabe Tadashi,Sakurai Minoru,Kanaya Koji,Ishihara Keiichi,Inoue Tetsuo,Kumita Shin-ichiro,Sakamoto Atsuhiro
Journal of Nippon Medical School 80(5), 342-349, 2013
… We also compared the flow rates of sodium, potassium, carbohydrates, and osmotically active particles in the 2 test fluids. … The flow rates of sodium, potassium, and glucose differed significantly between OS-1® and Pocari Sweat®, whereas the flow rate of osmotically active particles did not. …
NAID 130004147248