WordNet

abnormally large red blood cell present in pernicious anemia and folic acid deficiency

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1. ビタミンB12および葉酸欠乏症の生理学 physiology of vitamin b12 and folate deficiency
2. 骨髄穿刺塗抹標本の評価 evaluation of bone marrow aspirate smears
3. Macrocytosis/Macrocytic anemia
4. ビタミンB12および葉酸欠乏症の病因および臨床症状 etiology and clinical manifestations of vitamin b12 and folate deficiency
5. 赤血球産生調節 regulation of erythropoiesis

English Journal

Natural autoantibodies may play a role in ineffective erythropoiesis during megaloblastic haemopoiesis.

Wiener E, Wickramasinghe SN.SourceDepartment of Haematology, St Mary's Hospital Medical School, London, England, UK.
Clinical and experimental immunology.Clin Exp Immunol.1991 Jan;83(1):121-5.
Marrow aspirates from 11 patients with megaloblastic haemopoiesis and from 14 healthy individuals with normoblastic haemopoiesis were studied for antibodies associated with polychromatic/orthochromatic erythroblasts, using an 125I-labelled anti-human immunoglobulin reagent and autoradiography. In ad
PMID 1824831

Megaloblastic hematopoiesis in vitro. Interaction of anti-folate receptor antibodies with hematopoietic progenitor cells leads to a proliferative response independent of megaloblastic changes.

Antony AC, Briddell RA, Brandt JE, Straneva JE, Verma RS, Miller ME, Kalasinski LA, Hoffman R.SourceDepartment of Medicine, Indiana University School of Medicine, Indianapolis 46202-5121.
The Journal of clinical investigation.J Clin Invest.1991 Jan;87(1):313-25.
We tested the hypothesis that anti-placental folate receptor (PFR) antiserum-mediated effects on hematopoietic progenitor cells in vitro of increased cell proliferation and megaloblastic morphology were independent responses. We determined that (a) purified IgG from anti-PFR antiserum reacted with p
PMID 1702099

Related Links

Megaloblast | definition of megaloblast by Medical dictionary

megaloblast [meg´ah-lo-blast″] a large, nucleated immature progenitor of an abnormal erythrocytic series, an abnormal counterpart to the normoblast; megaloblasts are present in the blood in certain anemias. adj., adj megaloblas´tic.