- 同
- OPC
- 同
- OPC
WordNet
- an infection caused by fungi of the genus Monilia or Candida (especially Candida albicans) (同)moniliasis, monilia disease
- of or relating to or located near the oropharynx
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 口腔咽頭および食道カンジダ症の治療 treatment of oropharyngeal and esophageal candidiasis
- 2. 口腔咽頭および食道カンジダ症の臨床症状 clinical manifestations of oropharyngeal and esophageal candidiasis
- 3. カンジダ感染症の概要 overview of candida infections
- 4. 小児におけるカンジダ感染症：概要 candida infections in children an overview
- 5. 新生児におけるカンジダ感染症の臨床症状および診断 clinical manifestations and diagnosis of candida infection in neonates
English Journal
- The Adaptor CARD9 Is Required for Adaptive but Not Innate Immunity to Oral Mucosal Candida albicans Infections.
- Bishu S1, Hernández-Santos N, Simpson-Abelson MR, Huppler AR, Conti HR, Ghilardi N, Mamo AJ, Gaffen SL.Author information 1Division of Gastroenterology, Hepatology & Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.AbstractOropharyngeal candidiasis (OPC [thrush]) is an opportunistic infection caused by the commensal fungus Candida albicans. OPC is common in individuals with HIV/AIDS, infants, patients on chemotherapy, and individuals with congenital immune defects. Immunity to OPC is strongly dependent on the interleukin-23 (IL-23)/IL-17R axis, as mice and humans with defects in IL-17R signaling (IL17F, ACT1, IL-17RA) or in genes that direct Th17 differentiation (STAT3, STAT1, CARD9) are prone to mucocutaneous candidiasis. Conventional Th17 cells are induced in response to C. albicans infection via signals from C-type lectin receptors, which signal through the adaptor CARD9, leading to production of Th17-inducing cytokines such as IL-6, IL-1β, and IL-23. Recent data indicate that IL-17 can also be made by numerous innate cell subsets. These innate "type 17" cells resemble conventional Th17 cells, but they can be activated without need for prior antigen exposure. Because C. albicans is not a commensal organism in rodents and mice are thus naive to this fungus, we had the opportunity to assess the role of CARD9 in innate versus adaptive responses using an OPC infection model. As expected, CARD9(-/-) mice failed to mount an adaptive Th17 response following oral Candida infection. Surprisingly, however, CARD9(-/-) mice had preserved innate IL-17-dependent responses to Candida and were almost fully resistant to OPC. Thus, CARD9 is important primarily for adaptive immunity to C. albicans, whereas alternate recognition systems appear to be needed for effective innate responses.
- Infection and immunity.Infect Immun.2014 Mar;82(3):1173-80. doi: 10.1128/IAI.01335-13. Epub 2013 Dec 30.
- Oropharyngeal candidiasis (OPC [thrush]) is an opportunistic infection caused by the commensal fungus Candida albicans. OPC is common in individuals with HIV/AIDS, infants, patients on chemotherapy, and individuals with congenital immune defects. Immunity to OPC is strongly dependent on the interleu
- PMID 24379290
- Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis.
- Ferreira MC1, Whibley N, Mamo AJ, Siebenlist U, Chan YR, Gaffen SL.Author information 1Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.AbstractOropharyngeal candidiasis (OPC; thrush) is an opportunistic fungal infection caused by the commensal microbe Candida albicans. Immunity to OPC is strongly dependent on CD4(+) T cells, particularly those of the Th17 subset. Interleukin-17 (IL-17) deficiency in mice or humans leads to chronic mucocutaneous candidiasis, but the specific downstream mechanisms of IL-17-mediated host defense remain unclear. Lipocalin 2 (Lcn2; 24p3; neutrophil gelatinase-associated lipocalin [NGAL]) is an antimicrobial host defense factor produced in response to inflammatory cytokines, particularly IL-17. Lcn2 plays a key role in preventing iron acquisition by bacteria that use catecholate-type siderophores, and lipocalin 2(-/-) mice are highly susceptible to infection by Escherichia coli and Klebsiella pneumoniae. The role of Lcn2 in mediating immunity to fungi is poorly defined. Accordingly, in this study, we evaluated the role of Lcn2 in immunity to oral infection with C. albicans. Lcn2 is strongly upregulated following oral infection with C. albicans, and its expression is almost entirely abrogated in mice with defective IL-17 signaling (IL-17RA(-/-) or Act1(-/-) mice). However, Lcn2(-/-) mice were completely resistant to OPC, comparably to wild-type (WT) mice. Moreover, Lcn2 deficiency mediated protection from OPC induced by steroid immunosuppression. Therefore, despite its potent regulation during C. albicans infection, Lcn2 is not required for immunity to mucosal candidiasis.
- Infection and immunity.Infect Immun.2014 Mar;82(3):1030-5. doi: 10.1128/IAI.01389-13. Epub 2013 Dec 16.
- Oropharyngeal candidiasis (OPC; thrush) is an opportunistic fungal infection caused by the commensal microbe Candida albicans. Immunity to OPC is strongly dependent on CD4(+) T cells, particularly those of the Th17 subset. Interleukin-17 (IL-17) deficiency in mice or humans leads to chronic mucocuta
- PMID 24343647
- Polymorphisms in Tumor Necrosis Factor-α Increase Susceptibility to Intra-Abdominal Candida Infection in High-Risk Surgical ICU Patients*
- Wójtowicz A1, Tissot F, Lamoth F, Orasch C, Eggimann P, Siegemund M, Zimmerli S, Flueckiger UM, Bille J, Calandra T, Marchetti O, Bochud PY; and the Fungal Infection Network of Switzerland (FUNGINOS).Author information 11Infectious Diseases Service, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland. 2Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, Basel University Hospital, Basel, Switzerland. 3Adult Intensive Care Service, Lausanne University Hospital (CHUV), Lausanne, Switzerland. 4Intensive Care Unit, Basel University Hospital, Basel, Switzerland. 5Institute for Infectious Diseases, University of Bern, Bern, Switzerland. 6Division of Infectious Disease, Internal Medicine Centre, Hirslanden Klink, Aarau, Switzerland. 7Institute of Microbiology, Department of Laboratories, Lausanne University Hospital (CHUV), Lausanne, Switzerland.AbstractOBJECTIVES:: To evaluate the influence of genetic polymorphisms on the susceptibility to Candida colonization and intra-abdominal candidiasis, a blood culture-negative life-threatening infection in high-risk surgical ICU patients.
- Critical care medicine.Crit Care Med.2014 Feb 19. [Epub ahead of print]
- OBJECTIVES:: To evaluate the influence of genetic polymorphisms on the susceptibility to Candida colonization and intra-abdominal candidiasis, a blood culture-negative life-threatening infection in high-risk surgical ICU patients.DESIGN:: Prospective observational cohort study.SETTING:: Surgical ICU
- PMID 24557424
Japanese Journal
- 造血幹細胞移植患者に対する周術期口腔機能管理
- 日本農村医学会雑誌 65(4), 766-779, 2016
- NAID 130005286699
- A Case of HIV Infection Detected at the Department of Otorhinolaryngology
- 耳鼻咽喉科臨床 補冊 138(0), 130-131, 2014
- NAID 130004834011
- 耳鼻咽喉科で診断されたHIV感染症例
- 耳鼻咽喉科臨床 106(8), 753-758, 2013-08-01
- NAID 10031188248
Related Links
- Oropharyngeal Candidiasis symptoms, causes, diagnosis, and treatment information for Oropharyngeal Candidiasis (Oral thrush) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and ...
- Management of Oropharyngeal and Esophageal Candidiasis in Patients With HIV Infection Jose A. Vazquez, MD, FACP, FIDSA CME Released: 05/04/2010; Valid for credit ... This activity is intended for primary care physicians ...
Related Pictures
★リンクテーブル★
| リンク元 | 「OPC」「中咽頭カンジダ症」 |
| 関連記事 | 「oropharyngeal」「candidiasis」 |
「OPC」
「中咽頭カンジダ症」
「oropharyngeal」
- adj.
- 中咽頭の、口咽頭の
「candidiasis」
- (pl.)candidiase