オキソグルタル酸オルニチン
WordNet
- an amino acid that does not occur in proteins but is important in the formation of urea
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/11/23 10:30:03」(JST)
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Ornithine oxoglutarate
Combination of |
Ornithine |
amino acid |
Alpha-ketoglutaric acid |
|
Clinical data |
Pregnancy cat. |
? |
Legal status |
? |
Identifiers |
CAS number |
34414-83-0 |
ATC code |
A05BA06 |
PubChem |
CID 78866 |
Y (what is this?) (verify)
|
Ornithine oxoglutarate (OGO) or ornithine α-ketoglutarate (OKG) is a drug used in liver therapy. It is the salt formed from ornithine and alpha-ketoglutaric acid. It is also used to improve nutritional health in elderly patients.[1][2]
References
- ^ Blonde-Cynober, F; Aussel, C; Cynober, L (2003). "Use of ornithine α-ketoglutarate in clinical nutrition of elderly patients". Nutrition 19 (1): 73–5. doi:10.1016/S0899-9007(02)00849-3. PMID 12507647.
- ^ Patrice Brocker, Bruno Vellas, Jean-Louis Albarede, Thierry Poynard (July 1994). "A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects". Age and Ageing. http://findarticles.com/p/articles/mi_m2459/is_n4_v23/ai_15657854.
Bile and liver therapy (A05)
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Bile therapy |
- bile acid (Chenodeoxycholic acid
- Cholic acid
- Ursodeoxycholic acid)
- Nicotinyl methylamide
- Piprozolin
- Hymecromone
- Cyclobutyrol
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Liver therapy |
- Arginine glutamate
- Silymarin
- Citiolone
- Epomediol
- Ornithine oxoglutarate
- Tidiacic arginine
- Glycyrrhizin
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anat(t, g, p)/phys/devp/enzy
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noco/cong/tumr, sysi/epon
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proc, drug(A2A/2B/3/4/5/6/7/14/16), blte
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UpToDate Contents
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English Journal
- Glutamine and ornithine alpha-ketoglutarate supplementation on malate dehydrogenases expression in hepatectomized rats.
- Guimarães Filho A1, Cunha RM2, Vasconcelos PR3, Guimarães SB3.
- Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia.Acta Cir Bras.2014 Jun;29(6):365-70.
- PURPOSE: To evaluate the relative gene expression (RGE) of cytosolic (MDH1) and mitochondrial (MDH2) malate dehydrogenases enzymes in partially hepatectomized rats after glutamine (GLN) or ornithine alpha-ketoglutarate (OKG) suplementation.METHODS: One-hundred and eight male Wistar rats were randoml
- PMID 24919044
- Alpha-ketoglutarate (AKG) inhibits proliferation of colon adenocarcinoma cells in normoxic conditions.
- Rzeski W1, Walczak K, Juszczak M, Langner E, Pożarowski P, Kandefer-Szerszeń M, Pierzynowski SG.
- Scandinavian journal of gastroenterology.Scand J Gastroenterol.2012 May;47(5):565-71. doi: 10.3109/00365521.2012.660539.
- BACKGROUND AND OBJECTIVE: Alpha-ketoglutarate (AKG), a key intermediate in Krebs cycle, is an important biological compound involved in the formation of amino acids, nitrogen transport, and oxidation reactions. AKG is already commercially available as a dietary supplement and its supplementation wit
- PMID 22486188
- Advances and challenges in the treatment of branched-chain amino/keto acid metabolic defects.
- Knerr I1, Weinhold N, Vockley J, Gibson KM.
- Journal of inherited metabolic disease.J Inherit Metab Dis.2012 Jan;35(1):29-40. doi: 10.1007/s10545-010-9269-1. Epub 2011 Feb 3.
- Disorders of branched-chain amino/keto acid metabolism encompass diverse entities, including maple syrup urine disease (MSUD), the 'classical' organic acidurias isovaleric acidemia (IVA), propionic acidemia (PA), methylmalonic acidemia (MMA) and, among others, rarely described disorders such as 2-me
- PMID 21290185
Related Links
- Oxoglurate D'Ornithine Mylan is a medicine available in a number of countries worldwide. A list of US medications equivalent to Oxoglurate D'Ornithine Mylan is available on the Drugs.com website.
- Biologicals, Amino acids, , L-ornithine is a basic amino acid and is important in the formation of urea. It is a nonprotein amino acid which means that it does not occur in proteins. The body uses it in the biosynthesis of L-arginine, L ...
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