WordNet
- any of a series of nerve agents containing organophosphate compounds first synthesized by German chemists in 1936; in World War II the Germans tested them in concentration camps but not on the battlefield; Iraq is alleged to have used them against Iran and against the Kurds
- a substance that exerts some force or effect
- a businessman who buys or sells for another in exchange for a commission (同)factor, broker
- any agent or representative of a federal agency or bureau (同)federal agent
- a representative who acts on behalf of other persons or organizations
- an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"
- how long something has existed; "it was replaced because of its age"
- a time of life (usually defined in years) at which some particular qualification or power arises; "she was now of school age"; "tall for his eld" (同)eld
- begin to seem older; get older; "The death of his wife caused him to age fast"
- make older; "The death of his child aged him tremendously"
- any bundle of nerve fibers running to various organs and tissues of the body (同)nervus
- an insecticide that interferes with an insects nervous system
- control of your emotions; "this kind of tension is not good for my nerves"
PrepTutorEJDIC
- 『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員
- 〈U〉(一般に)『年齢』,寿命;〈C〉(個々の)『年齢』,年 / 〈U〉成年(おとなとしての資格・権利を得る年齢;通例18または21歳) / 〈U〉『老齢』;《集合的に》老人たち / 〈U〉(人生の)『一時期』;〈C〉世代(generation) / 〈U〉〈C〉《しばしばA-》(歴史上の)『時代』 / 〈C〉《話》長い間 / 年をとる,ふける;〈物が〉古くなる / 〈年〉'を'とらせる;〈物〉'を'古びさせる
- 〈C〉『神経』 / 〈C〉《複数形で》『神経過敏』,いらだち / 〈U〉『勇気』,度胸(courage) / 〈U〉《時にa ~》厚かましさ,ずぶとさ;無礼 / 〈C〉葉脈;(昆虫の)翅脈(しみゃく) / 〈人,特に自分〉‘に'力を与える,‘を'元気づける
UpToDate Contents
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English Journal
- Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.
- Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M, Verdier L, Masson P, Rochu D, Jun D, Nachon F.SourceDepartement de Toxicologie, Institut de Recherches Biomedicales des Armees, 38700 La Tronche, France.
- Toxicology letters.Toxicol Lett.2011 Sep 25;206(1):14-23. Epub 2011 Jun 12.
- Bioscavengers are molecules able to neutralize neurotoxic organophosphorus compounds (OP) before they can reach their biological target. Human butyrylcholinesterase (hBChE) is a natural bioscavenger each molecule of enzyme neutralizing one molecule of OP. The amount of natural enzyme is insufficient
- PMID 21683774
- Long-term evaluation of organophosphate toxicity and antidotal therapy in co-cultures of spinal cord and muscle tissue.
- Drexler B, Seeger T, Grasshoff C, Thiermann H, Antkowiak B.SourceDepartment of Anaesthesiology, Experimental Anaesthesiology Section, Eberhard-Karls-University, Schaffhausenstr. 113, 72072 Tuebingen, Germany.
- Toxicology letters.Toxicol Lett.2011 Sep 25;206(1):89-93. Epub 2011 Apr 20.
- Victims of nerve agents basically require antidotal treatment. There is need for novel antidotes and for therapeutic procedures that are specifically adapted to these patients. To cope with this challenge, in vitro test systems which are easy to handle and allow for conducting long-term studies woul
- PMID 21530620
- Nerve agent intoxication: Recent neuropathophysiological findings and subsequent impact on medical management prospects.
- Collombet JM.AbstractThis manuscript provides a survey of research findings catered to the development of effective countermeasures against nerve agent poisoning over the past decade. New neuropathophysiological distinctive features as regards organophosphate (OP) intoxication are presented. Such leading neuropathophysiological features include recent data on nerve agent-induced neuropathology, related peripheral or central nervous system inflammation and subsequent angiogenesis process. Hence, leading countermeasures against OP exposure are down-listed in terms of pre-treatment, protection or decontamination and emergency treatments. The final chapter focuses on the description of the self-repair attempt encountered in lesioned rodent brains, up to 3months after soman poisoning. Indeed, an increased proliferation of neuronal progenitors was recently observed in injured brains of mice subjected to soman exposure. Subsequently, the latter experienced a neuronal regeneration in damaged brain regions such as the hippocampus and amygdala. The positive effect of a cytokine treatment on the neuronal regeneration and subsequent cognitive behavioral recovery are also discussed in this review. For the first time, brain cell therapy and neuronal regeneration are considered as a valuable contribution towards delayed treatment against OP intoxication. To date, efficient delayed treatment was lacking in the therapeutic resources administered to patients contaminated by nerve agents.
- Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2011 Sep 15;255(3):229-41. Epub 2011 Jul 26.
- This manuscript provides a survey of research findings catered to the development of effective countermeasures against nerve agent poisoning over the past decade. New neuropathophysiological distinctive features as regards organophosphate (OP) intoxication are presented. Such leading neuropathophysi
- PMID 21791221
Related Links
- Nerve agents are a class of phosphorus-containing organic chemicals ( organophosphates) that disrupt the mechanism by which nerves transfer messages to organs. The disruption is caused by blocking acetylcholinesterase, an enzyme that ...
- Their potential use as chemical warfare agents soon became apparent, and the ...
★リンクテーブル★
[★]
- 代行者、代理人。代理業者
- 政府職員、官吏
- ある後位をする人、ある作用をするもの。動員、動力因、作用因。(文法)動作主。科学的変化を起こさせるもの、薬品、~剤。病原体
- 関
- agonist、agonistic、attorney、delegate、drug、etiologic agent、fomes、fomites、mediator、pathogen、pathogenic、pharmaceutical preparation、vector、vehicle
[★]
有機リン酸、(化合物)有機リン酸塩、有機リン
- 関
- organic phosphate、organic phosphorus、organophosphorus、phosphoric acid ester
[★]
- 関
- aged、ageing、aging、year old
[★]
- 関
- nervi、nervous、nervus、neural、neuro、neuron
[★]
- 関
- nerve gas