organic cation transporters

同

OCTs

WordNet

1. simple and healthful and close to nature; "an organic lifestyle"
2. a fertilizer that is derived from animal or vegetable matter (同)organic fertilizer, organic fertiliser
3. being or relating to or derived from or having properties characteristic of living organisms; "organic life"; "organic growth"; "organic remains found in rock"
4. involving or affecting physiology or bodily organs; "an organic disease"
5. of or relating to foodstuff grown or raised without synthetic fertilizers or pesticides or hormones; "organic eggs"; "organic vegetables"; "organic chicken"
6. relating or belonging to the class of chemical compounds having a carbon basis; "hydrocarbons are organic compounds"
7. wind instrument whose sound is produced by means of pipes arranged in sets supplied with air from a bellows and controlled from a large complex musical keyboard (同)pipe_organ
8. a fully differentiated structural and functional unit in an animal that is specialized for some particular function
9. a government agency or instrument devoted to the performance of some specific function; "The Census Bureau is an organ of the Commerce Department"
10. a periodical that is published by a special interest group; "the organ of the communist party"
11. a long truck for carrying motor vehicles (同)car transporter
12. a crane for moving material with dispatch as in loading and unloading ships
13. a positively charged ion

PrepTutorEJDIC

1. 有機体の,生物の,生物から生じた / (動植物の)器官の / 有機肥料を用いる(を用いて育った)・有機的な,組織的な,系統的な・有機質の
2. 『オルガン』,パイプオルガン(pipe organ),リードオルガン(reed organ),電子オルガン(electronic organ),手回しオルガン(barrel organ) / (動植物の)『器官』 / (政党・会社などの)機関誌,機関紙 / 《しばしば複数形で》(行動・実施などの)組織,機関
3. 自動車運搬用大型トラック
4. 陽イオン,正イオン

UpToDate Contents

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English Journal

• Renal PET-imaging with (11)C-metformin in a transgenic mouse model for chronic kidney disease.

• Pedersen L1, Jensen JB1,2, Wogensen L1, Munk OL2, Jessen N1, Frøkiær J2, Jakobsen S3.
• EJNMMI research.EJNMMI Res.2016 Dec;6(1):54. doi: 10.1186/s13550-016-0211-x. Epub 2016 Jun 23.
• BACKGROUND: Organic cation transporters (OCTs) in the renal proximal tubule are important for the excretion of both exo- and endogenous compounds, and chronic kidney disease (CKD) alter the expression of OCT. Metformin is a well-known substrate for OCT, and recently, we demonstrated that positron em
• PMID 27339044

• The inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs).

• Zheng J1,2, Chan T2, Zhu L3, Yan X1, Cao Z4, Wang Y1, Zhou F2.
• Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2016 Sep;46(9):831-40. doi: 10.3109/00498254.2015.1129080. Epub 2016 Jan 8.
• 1. Camptothecin (CPT) and its derivatives are potent candidate compounds in treating cancers. However, their clinical applications are largely restricted by severe toxicities. 2. The solute carrier transporters (SLCs), particularly the organic anion transporting polypeptides and organic anion/ca
• PMID 26744836

• ELS1, a novel MATE transporter related to leaf senescence and iron homeostasis in Arabidopsis thaliana.

• Wang Z1, Qian C2, Guo X3, Liu E4, Mao K5, Mu C6, Chen N7, Zhang W8, Liu H9.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Aug 5;476(4):319-25. doi: 10.1016/j.bbrc.2016.05.121. Epub 2016 May 24.
• The multidrug and toxic compound extrusion (MATE) transporters mediate the coupled exchange of organic substrates and monovalent cations have been recently implicated in various plant biological activities. In this work, we isolated a dominant mutant from an Arabidopsis activation-tagging mutant poo
• PMID 27233612

Japanese Journal

• Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)

• Tamai Ikumi
• Biopharmaceutics and Drug Disposition xx(xx), xxxx-xxxx, 2012-00-00
• … The carnitine/organic cation transporter (OCTN) family consists of three transporter isoforms, i.e. OCTN1 (SLC22A4) and OCTN2 (SLC22A5) in humans and animals and Octn3 (Slc22a21) in mice. … These transporters are physiologically essential to maintain appropriate systemic and tissue concentrations of carnitine by regulating its membrane transport during intestinal absorption, tissue distribution and renal reabsorption. …
• NAID 120004997007

• 有機カチオン輸送系を介した白金系抗がん剤の腎毒性発現機構

• 米澤 淳
• 薬学雑誌 132(11), 1281-1285, 2012
• … Organic cation transporter (OCT)/SLC22A, and multidrug and toxin extrusion (MATE)/SLC47A play a role in renal handling of cationic drug in the kidney. … We focused on a role of transporters in nephrotoxicity of platinum agents. … Moreover, carboplatin and nedaplatin were not transported by these transporters. …
• NAID 130001871984

• Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins

• HOSOYA Ken-ichi,TACHIKAWA Masanori
• Clinical and experimental nephrology 15(4), 478-485, 2011-08-01
• NAID 10029571602

Related Links

• Organic cation transport proteins - Wikipedia, the free encyclopedia

An organic cation transport protein mediates the transport of organic cations across the cell membrane. These proteins are members of the solute carrier family, subfamily 22. This family of proteins can also transport zwitterions and anions, ...

• SLC22A1 - Wikipedia, the free encyclopedia

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three ...

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★リンクテーブル★

リンク元	「OCTs」
関連記事	「organic」「transporter」「cation」「organ」

「OCTs」

　　[★]

同

organic cation transporters

「organic」

　　[★]

• adj.

• 有機物の、有機の、有機的な、器質性の、器質的な

関

organic compound、organic matter、organized、organo

　 　 　 　 　 　 　

「transporter」

　　[★] トランスポーター

関

translocator、transport protein、transporter protein

　 　 　

「cation」

　　[★]

• 陽イオン、カチオン

関

cationic

関

See also specific cations

　 　

「organ」

　　[★]

• n.

• 臓器、器官