WordNet
- simple and healthful and close to nature; "an organic lifestyle"
- a fertilizer that is derived from animal or vegetable matter (同)organic fertilizer, organic fertiliser
- being or relating to or derived from or having properties characteristic of living organisms; "organic life"; "organic growth"; "organic remains found in rock"
- involving or affecting physiology or bodily organs; "an organic disease"
- of or relating to foodstuff grown or raised without synthetic fertilizers or pesticides or hormones; "organic eggs"; "organic vegetables"; "organic chicken"
- relating or belonging to the class of chemical compounds having a carbon basis; "hydrocarbons are organic compounds"
- move something or somebody around; usually over long distances
- an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
- move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
- transport commercially (同)send, ship
- wind instrument whose sound is produced by means of pipes arranged in sets supplied with air from a bellows and controlled from a large complex musical keyboard (同)pipe_organ
- a fully differentiated structural and functional unit in an animal that is specialized for some particular function
- a government agency or instrument devoted to the performance of some specific function; "The Census Bureau is an organ of the Commerce Department"
- a periodical that is published by a special interest group; "the organ of the communist party"
- a long truck for carrying motor vehicles (同)car transporter
- a crane for moving material with dispatch as in loading and unloading ships
- a negatively charged ion
PrepTutorEJDIC
- 有機体の,生物の,生物から生じた / (動植物の)器官の / 有機肥料を用いる(を用いて育った)・有機的な,組織的な,系統的な・有機質の
- (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
- 『オルガン』,パイプオルガン(pipe organ),リードオルガン(reed organ),電子オルガン(electronic organ),手回しオルガン(barrel organ) / (動植物の)『器官』 / (政党・会社などの)機関誌,機関紙 / 《しばしば複数形で》(行動・実施などの)組織,機関
- 自動車運搬用大型トラック
- 陰イオン
UpToDate Contents
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- 1. Chapter 3C：近位尿細管における分泌経路 chapter 3c secretory pathways in proximal tubule
- 2. 尿酸のバランス uric acid balance
- 3. Chapter 3B：近位尿細管におけるナトリウム輸送能の優越性 chapter 3b primacy of sodium transport in proximal function
- 4. 低尿酸血症：原因および臨床的意義 hypouricemia causes and clinical significance
- 5. 小児における先天性代謝異常の評価の概要 overview of the evaluation of inborn errors of metabolism in children
English Journal
- Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice.
- Li JM, Zhang X, Wang X, Xie YC, Kong LD.AbstractThe aim of the present study was to investigate the effects of cortex fraxini coumarines esculetin, esculin, fraxetin and fraxin on renal dysfunction and expression abnormality of renal organic ion transporters in hyperuricemic animals. Mice were orally given 250mg/kg oxonate for seven consecutive days to induce hyperuricemia and renal dysfunction. After 1h of oxonate induction daily, animals were orally treated with esculetin, esculin, fraxetin and fraxin at 20 and 40mg/kg, respectively. Esculetin, esculin, fraxetin and fraxin significantly decreased serum urate, creatinine and blood urea nitrogen levels and increased urine urate and creatinine excretion in hyperuricemic mice. Esculetin and esculin up-regulated expressions of renal organic anion transporter 1 (mOAT1), organic cation and carnitine transporters (mOCT1-2 and mOCTN1-2), but failed to affect renal glucose transporter 9 (mGLUT9) and urate transporter 1 (mURAT1) in this model. Fraxetin specifically inhibited renal mURAT1, while fraxin extensively interacted with renal mGLUT9, mURAT1, mOAT1 and mOCT1 in hyperuricemic mice. Furthermore, esculetin, fraxetin and fraxin increased mABCG2 mRNA expression and decreased its protein levels in renal apical membrane in hyperuricemic mice. These results indicate that esculetin and esculin have beneficial effects on hyperuricemia and renal dysfunction, resulting in restoration of mOAT1, mOCT1-2 and mOCTN1-2, and fraxetin and fraxin enhance urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice. Regulation of mABCG2 by cortex fraxini coumarines may be partly contributed to their beneficial actions. This study provides an evidence to support clinical therapeutic effects of cortex fraxini coumarines on hyperuricemia with renal dysfunction.
- European journal of pharmacology.Eur J Pharmacol.2011 Sep;666(1-3):196-204. Epub 2011 May 23.
- The aim of the present study was to investigate the effects of cortex fraxini coumarines esculetin, esculin, fraxetin and fraxin on renal dysfunction and expression abnormality of renal organic ion transporters in hyperuricemic animals. Mice were orally given 250mg/kg oxonate for seven consecutive d
- PMID 21620826
- Regulation of drug transporter expression by oncostatin M in human hepatocytes.
- Le Vee M, Jouan E, Stieger B, Lecureur V, Fardel O.SourceEA 4427 SeRAIC, Institut de Recherches Sante, Environnement et Travail, Universite de Rennes 1, 2 Avenue du Pr L. Bernard, 35043 Rennes, France.
- Biochemical pharmacology.Biochem Pharmacol.2011 Aug 1;82(3):304-11. Epub 2011 May 6.
- The cytokine oncostatin M (OSM) is a member of the interleukin (IL)-6 family, known to down-regulate expression of drug metabolizing cytochromes P-450 in human hepatocytes. The present study was designed to determine whether OSM may also impair expression of sinusoidal and canalicular drug transport
- PMID 21570956
Japanese Journal
- Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes
- Takeba Yuko,Matsumoto Naoki,Takenoshita-Nakaya Sachiko,Harimoto Yoshie,Kumai Toshio,Kinoshita Yuichi,Nakano Hiroshi,Ohtsubo Takehito,Kobayashi Shinichi
- Journal of Pharmacological Sciences 115(4), 516-524, 2011
- … Serum-free WEM and Lanford’s also maintained protein levels of CYP2C19, CYP2D6, and organic anion transporter polypeptide in the hepatocytes. … Serum-free WEM and Lanford’s may be appropriate culture media for maintaining CYP3A4 and drug transporter protein levels in primary cultured hepatocytes. …
- NAID 130000663517
- Screening of Antibiotics That Interact with Organic Anion-Transporting Polypeptides 1B1 and 1B3 Using Fluorescent Probes
- Yamaguchi Hiroaki,Takeuchi Toshiko,Okada Masahiro,Kobayashi Minako,Unno Michiaki,Abe Takaaki,Goto Junichi,Hishinuma Takanori,Shimada Miki,Mano Nariyasu
- Biological & Pharmaceutical Bulletin 34(3), 389-395, 2011
- … Hepatic organic anion transporters OATP1B1 and OATP1B3 are expressed at the sinusoidal membrane of hepatocytes and contribute to the hepatic uptake of a wide variety of clinically used drugs. … To identify the antibiotics that interact with the human organic anion transporters OATP1B1 and OATP1B3, we applied a screening system using fluorescent probes. … Macrolides were not significantly transported by either transporter. …
- NAID 130000657818
Related Links
- organic anion transporter 2の意味や和訳。 * 有機アニオン輸送体2, 有機アニオン トランスポーター2 - 約486万語ある英和辞典・和英辞典。発音・イディオムも分かる 英語辞書。
Related Pictures
★リンクテーブル★
| リンク元 | 「有機アニオン輸送体2」「有機アニオントランスポーター2」 |
| 関連記事 | 「transport」「organic」「anion transporter」「transporter」「ani」 |
「有機アニオン輸送体2」
- 英
- organic anion transporter 2
- 関
- 有機アニオントランス・ーター2
「有機アニオントランスポーター2」
「transport」
- n.
- v.
- 輸送する、運搬する、運ぶ
「organic」
- adj.
- 有機物の、有機の、有機的な、器質性の、器質的な
「anion transporter」
「transporter」
「ani」
- np