WordNet

a bronchodilator (trade name Alupent) used to treat asthma and emphysema and other lung conditions; available in oral or inhalant forms; side effects include tachycardia and shakiness (同)Alupent

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/19 20:13:28」(JST)

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Orciprenaline (INN, also known as metaproterenol) is a bronchodilator used in the treatment of asthma. Orciprenaline is a moderately selective beta₂-adrenergic receptor agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. The pharmacologic effects of beta adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of ATP to cAMP. Increased cAMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from many cells, especially from mast cells.

Possible side effects

tremor
nervousness
dizziness
weakness
headache
nausea
tachycardia

Rare side effects that could be life threatening

increased difficulty breathing
rapid or increased heart rate
irregular heartbeat
chest pain or discomfort

Brand names

Alupent
Metaprel

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 喘息におけるβ刺激剤：急性期投与および予防的使用 beta agonists in asthma acute administration and prophylactic use
2. 12歳未満の小児における慢性喘息：初回評価および診断 asthma in children younger than 12 years rescue treatment for acute symptoms
3. 妊娠中の喘息のマネージメント management of asthma during pregnancy
4. 高カリウム性周期性四肢麻痺 hyperkalemic periodic paralysis
5. 術後肺合併症のマネージメントの概要 overview of the management of postoperative pulmonary complications

English Journal

[Right ventricular outflow tract tachycardia 30 years after surgical correction of tetralogy of Fallot].

Bellmann B1, Tscholl V, Nagel P, Roser M.
Herzschrittmachertherapie & Elektrophysiologie.Herzschrittmacherther Elektrophysiol.2015 May 20. [Epub ahead of print]
This case report describes a 31-year-old man with a sustained wide complex tachycardia with left bundle brunch block morphology after surgical repair of a tetralogy of Fallot. The tachycardia was inducible after orciprenaline administration after ventricular stimulation with one extra beat. In combi
PMID 25990265

Enhanced endothelium-dependent relaxation of rat pulmonary artery following β-adrenergic overstimulation: involvement of the NO/cGMP/VASP pathway.

Davel AP1, Victorio JA2, Delbin MA2, Fukuda LE3, Rossoni LV3.
Life sciences.Life Sci.2015 Mar 15;125:49-56. doi: 10.1016/j.lfs.2015.01.018. Epub 2015 Jan 29.
AIMS: The aim of this study was to investigate whether β-adrenoceptor (β-AR) overstimulation induced by in vivo treatment with isoproterenol (ISO) alters vascular reactivity and nitric oxide (NO) production and signaling in pulmonary arteries.MAIN METHODS: Vehicle or ISO (0.3mgkg(-1)day(-1)) was a
PMID 25640757

Insights from preclinical ultra high-density electroanatomical sinus node mapping.

Bollmann A1, Hilbert S2, John S2, Kosiuk J2, Hindricks G2.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.Europace.2015 Mar;17(3):489-94. doi: 10.1093/europace/euu276. Epub 2014 Oct 27.
AIMS: Although sinus node modification by catheter ablation is an established therapy for the treatment of inappropriate sinus tachycardia, there is incomplete understanding of sinus node anatomy and function but also limited electroanatomical mapping data. Recently, an automatic, ultra high-resolut
PMID 25349222

Japanese Journal

Screening of β-2 agonists and confirmation of fenoterol, orciprenaline, reproterol and terbutaline with gas chromatography-mass spectrometry as tetrahydroisoquinoline derivatives

HENZE Maria Kristina,OPFERMANN Georg,SPAHN-LANGGUTA Hildegard,SCHANZER Wilhelm
Journal of chromatography. B, Biomedical sciences and applications 751(1), 93-105, 2001-02-10
NAID 10012266160

シロスタゾールにより心拍数の増加と日常生活動作能力の向上を認めた洞機能不全症候群の一例

山下純世,宮川浩一,稲垣俊明,土肥靖明
日本老年医学会雑誌 36(8), 561-564, 1999-08-25
症例は86歳, 男性. 高血圧症に対しカルシウム拮抗薬の内服治療中であったが徐脈の原因となる薬剤の服用歴はなかった. 平成10年1月, 初診時の12誘導心電図で洞性徐脈と完全右脚+左脚前枝ブロックを認め, 精査治療目的で入院となった. ホルター心電図検査では一日総心拍数の減少 (74,182/日) と2秒以上の心停止 (187/日) を認めた. 電気生理学的検査では修正洞結節機能回復時間の延長(5 …
NAID 10008485316

イソフルレン吸入を施行した小児気管支喘息の重積発作の2例

田中秀典,浅井朋子,武田紹,影山里実,藤田直也,志水麻実子,岸真司,石井睦夫,矢守信昭,神田康司,上村治,側島久典,岩佐充二,安藤恒三郎
日本小児アレルギー学会誌 12(3), 281-287, 1998
症例1は5才2ヵ月女児. 3ヵ月前から喘息コントロールのため他院に入院していたが, 呼吸不全のため当院に搬送入院, 直ちに人工換気を施行した. 入院3日目皮下気腫を併発, イソフルレンを23時間投与し入院4日目に抜管できた. 症例2は11才女児. フェノテロールエアロゾル, オルシプレリン吸入等で他院で治療されていた. 当院受診時大発作で, 種々の治療により一旦軽快傾向を示したが, 数時間後増悪し …
NAID 130004370539

Related Pictures

★リンクテーブル★

リンク元	「オルシプレナリン」「metaproterenol」
拡張検索	「orciprenaline sulfate」

「オルシプレナリン」

Orciprenaline
Systematic (IUPAC) name
	(RS)-5-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,3-diol
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682084
Pregnancy cat.	A (AU) C (US)
Legal status	℞-only (US)
Routes	Inhalation / tablets
Pharmacokinetic data
Bioavailability	3% if inhaled, 40% if taken orally
Metabolism	Gastrointestinal and hepatic
Half-life	6 hours
Identifiers
CAS number	586-06-1
ATC code	R03AB03 R03CB03; R03CB53
PubChem	CID 4086
DrugBank	DB00816
ChemSpider	3944
UNII	53QOG569E0
KEGG	D08300
ChEMBL	CHEMBL776
Chemical data
Formula	C11H17NO3
Mol. mass	211.258 g/mol
	SMILES Oc1cc(cc(O)c1)C(O)CNC(C)C;
	InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8/h3-5,7,11-15H,6H2,1-2H3 ; Key:LMOINURANNBYCM-UHFFFAOYSA-N ;
Physical data
Solubility in water	9.7 mg/mL (20 °C)
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