オプトヒン
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/18 15:37:59」(JST)
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| Optochin |
|
IUPAC name
(4β,8α,9R)-6'-Ethoxy-10,11-dihydrocinchonan-9-ol
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| Identifiers |
| CAS number |
522-60-1 Y |
| PubChem |
71542 |
| MeSH |
Optochin |
| ChEMBL |
CHEMBL534999 N |
| Properties |
| Molecular formula |
C21H28N2O2 |
| Molar mass |
340.46 g/mol |
N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
| Infobox references |
Optochin (or ethylhydrocupreine) is a chemical used in cell culture techniques for the presumptive identification of Streptococcus pneumoniae, which is optochin-sensitive, from other alpha-hemolytic streptococci such as Streptococcus viridans, which are resistant. A common mnemonic is "OVRPS" (Optochin - Viridans [are] Resistant, Pneumoniae [are] Sensitive). Or "VROPS" (Viridans Resistant [to] Optochin, Pneumoniae Sensitive)
The growth of Bacteria that are optochin-sensitive will be inhibited around an optochin disc, while the growth of bacteria that are optochin-resistant will not be affected. In vitro, a solution of as little as 1:10,000,000 may be inhibitory to the pneumococcus, and 1:500,000 is bactericidal.[1]
Resistance[edit]
Strains of Streptococcus pneumoniae have been found to be resistant to optochin in laboratory testing.[2]
References[edit]
- ^ http://chestofbooks.com/health/materia-medica-drugs/Pharmacology-Therapeutics-Prescription-Writing/Ethylhydrocupreine.html
- ^ Pikis A, Campos JM, Rodriguez WJ, Keith JM (2001), "Optochin resistance in Streptococcus pneumoniae: mechanism, significance, and clinical implications", Journal of Infectious Diseases 184 (5): 582–590, doi:10.1086/322803, PMID 11474432
UpToDate Contents
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English Journal
- Stress-triggered signaling affecting survival or suicide of Streptococcus pneumoniae.
- Cortes PR1, Piñas GE1, Cian MB1, Yandar N1, Echenique J2.
- International journal of medical microbiology : IJMM.Int J Med Microbiol.2015 Jan;305(1):157-69. doi: 10.1016/j.ijmm.2014.12.002. Epub 2014 Dec 9.
- Streptococcus pneumoniae is a major human pathogen that can survive to stress conditions, such as the acidic environment of inflammatory foci, and tolerates lethal pH through a mechanism known as the acid tolerance response. We previously described that S. pneumoniae activates acidic-stress induced
- PMID 25543170
- Late-onset bleb-related endophthalmitis caused by Streptococcus pseudopneumoniae.
- Kawakami H1, Nakane Y, Inuzuka H, Fukagawa T, Muto T, Mochizuki K, Ohkusu K, Suematsu H, Yamagishi Y, Mikamo H.
- International ophthalmology.Int Ophthalmol.2014 Jun;34(3):643-6. doi: 10.1007/s10792-013-9835-2. Epub 2013 Jul 25.
- We report our findings in a 63-year-old male who developed late-onset bleb-related endophthalmitis. The patient had undergone glaucoma surgery 46 years earlier, and had a thin-walled cystic bleb prior to the endophthalmitis in his right eye. He underwent immediate vitrectomy with intravitreal inject
- PMID 23884602
- Feasibility of matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) networking in university hospitals in Brussels.
- Martiny D1, Cremagnani P, Gaillard A, Miendje Deyi VY, Mascart G, Ebraert A, Attalibi S, Dediste A, Vandenberg O.
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.Eur J Clin Microbiol Infect Dis.2014 May;33(5):745-54. doi: 10.1007/s10096-013-2006-6. Epub 2013 Nov 7.
- The mutualisation of analytical platforms might be used to address rising healthcare costs. Our study aimed to evaluate the feasibility of networking a unique matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) system for common use in several university hospi
- PMID 24197439
Japanese Journal
- Genetic Characterization of Optochin-Susceptible Viridans Group Streptococci
- Comparative study on the action of various derivatives of cinchona-alkaloids upon the electrically produced ventricular fibrillation of isolated frog's heart
- 厚地 千恵子
- 日本薬理学雑誌 51(3), 218-228,en19, 1955
- … Quinine sulfonic acid, quitenine, hydrochloroquinine, cinchonine, cinchonidine sulfonic acid, apoquinine, optochin, optochin-chloromethylate, quininetetrasulfate, cinchonidine tetrasulfate, all were found to be far less effective. …
- NAID 130001508249
Related Links
- Optochin Susceptibility Test What is the purpose of the test? Optochin is a chemical that is toxic to some bacteria but harmless to others. It is useful in the identification of Streptococcus pneumoniae, the alpha-hemolytic ...
- Streptococcus pneumoniae strains are sensitive to the chemical optochin (ethylhydrocupreine hydrochloride). Optochin sensitivity allows for the presumptive identification of alpha-hemolytic streptococci as S. pneumoniae, although ...
★リンクテーブル★
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- 英
- optochin
- 肺炎球菌の分離・同定に用いる
- IUPAC name (6-ethoxy-4-quinolyl)- 5-ethyl-2-quinuclidinyl)methanol
- α溶血性の連鎖球菌のうち、オプトヒン感受性なのは肺炎球菌のみである。