opioid receptor antagonist

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/04/24 17:58:18」(JST)

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  • Baclofen prevents the elevated plus maze behavior and BDNF expression during naloxone precipitated morphine withdrawal in male and female mice.
  • Pedrón VT1, Varani AP1,2, Balerio GN1,2.
  • Synapse (New York, N.Y.).Synapse.2016 May;70(5):187-97. doi: 10.1002/syn.21886. Epub 2016 Feb 16.
  • In previous studies we have shown that baclofen, a selective GABAB receptor agonist, prevents the somatic expression and reestablishes the dopamine and μ-opioid receptors levels, modified during naloxone-precipitated morphine withdrawal syndrome in male and female mice. There are no previous report
  • PMID 26789010
  • Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons.
  • Ardianto C1, Yonemochi N1, Yamamoto S1, Yang L1, Takenoya F2, Shioda S3, Nagase H4, Ikeda H5, Kamei J1.
  • Neuroscience.Neuroscience.2016 Apr 21;320:183-93. doi: 10.1016/j.neuroscience.2016.02.002. Epub 2016 Feb 6.
  • The hypothalamus controls feeding behavior. Since central opioid systems may regulate feeding behavior, we examined the role of μ-, δ- and κ-opioid receptors in the lateral hypothalamus (LH), the hunger center, in feeding behavior of mice. Non-selective (naloxone; 3mg/kg, s.c.) and selective μ-
  • PMID 26855191
  • Intrathecal administration of low-dose nociceptin/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1.
  • Kawabata K1, Nishimura I1, Fujiwara T1, Terauchi S1, Minami T2, Ito S3, Okuda-Ashitaka E1.
  • The European journal of neuroscience.Eur J Neurosci.2016 Apr 2. doi: 10.1111/ejn.13247. [Epub ahead of print]
  • Pathological chronic pain, which is frequently associated with prolonged tissue damage, inflammation, tumor invasion, and neurodegenerative diseases, gives rise to hyperalgesia and allodynia. We previously reported that intrathecal administration of nociceptin/orphanin FQ (N/OFQ), an endogenous liga
  • PMID 27038234


  • ナロキソン (特集 拮抗作用から見た麻酔関連薬物の最新知見)
  • Antihyperalgesic Effect of Buprenorphine Involves Nociceptin/Orphanin FQ Peptide–Receptor Activation in Rats With Spinal Nerve Injury–Induced Neuropathy
  • Takahashi Tomoko,Okubo Kazumasa,Kojima Shota,Nishikawa Hiroyuki,Takemura Motohide,Tsubota-Matsunami Maho,Sekiguchi Fumiko,Kawabata Atsufumi
  • Journal of Pharmacological Sciences, 2013
  • … We evaluated the effect of buprenorphine, a mixed agonist for μ-opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors, in neuropathic rats, using the paw pressure test. … Intrathecal injection of [N-Phe1]nociceptin(1-13)NH2, a NOP-receptor antagonist, reversed the effect of buprenorphine in neuropathic rats, but not in naïve rats. …
  • NAID 130003362701
  • Naloxone Blocks the Deterioration of Male Sexual Behavior Induced by Alarm Pheromone in Rats
  • Journal of Veterinary Medical Science, 2013
  • … Previously, we have demonstrated that the alarm pheromone deteriorates sexual behavior in male rats, which was blocked by pretreatment with a corticotrophin-releasing hormone (CRH) antagonist. … Studies have shown that an opioid antagonist blocked the deterioration of male sexual behavior following intracerebroventricular administration of CRH. … Therefore, possibly, the pheromone effects could also be mediated by the opioid system. …
  • NAID 130003362126


Xiidra Xiidra (lifitegrast) is a lymphocyte function-associated antigen-1 (LFA-1) antagonist indicated for... Syndros Syndros (dronabinol) is an orally administered liquid formulation of the pharmaceutical cannabinoid... Epclusa Epclusa ...
Opiate antagonists work by binding to the opioid receptors to stop the body's reaction to opiates or opioids and in some cases can reverse the effects. ... The term opiate antagonist or opioid antagonist is used to describe a receptor ...


Antagonist VS Agonist - ThingLinkAgonists and Antagonists Mu Opioid Receptor Bound to a Morphinan AntagonistsBeschreibung Mu-opioid receptor.pngAntagonistas geralmente atuam no sistema

関連記事antagonist」「receptor」「opioid」「opioid receptor


  [★] 拮抗薬

WordNet   license wordnet

「a drug that neutralizes or counteracts the effects of another drug」

WordNet   license wordnet

「a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"」

PrepTutorEJDIC   license prepejdic



  [★] 受容体

WordNet   license wordnet

「a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response」

PrepTutorEJDIC   license prepejdic

「=sense organ / 受信装置」


  [★] オピオイド


opioid receptor」

  [★] オピオイド受容体