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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/01 01:50:52」(JST)

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  • The use of biologicals in cutaneous allergies - present and future.
  • Makris MP1, Papadavid E, Zuberbier T.
  • Current opinion in allergy and clinical immunology.Curr Opin Allergy Clin Immunol.2014 Oct;14(5):409-16. doi: 10.1097/ACI.0000000000000096.
  • PURPOSE OF REVIEW: Up-to-date biologicals in cutaneous allergies play - unfortunately - only a minor role. However, this situation might change. Recently, omalizumab was licensed for chronic urticaria; this article reviews recent advances in the use of biologicals in cutaneous allergies.RECENT FINDI
  • PMID 25102106
  • Omalizumab management beyond clinical trials: The added value of a network model.
  • Caminati M1, Senna G2, Chieco Bianchi F3, Marchi MR4, Vianello A5, Micheletto C6, Pomari C7, Tognella S8, Savoia F9, Mirisola V10, Rossi A11; NEONET Study Group.
  • Pulmonary pharmacology & therapeutics.Pulm Pharmacol Ther.2014 Oct;29(1):74-9. doi: 10.1016/j.pupt.2014.01.007. Epub 2014 Feb 6.
  • BACKGROUND: Omalizumab is effective and safe in severe allergic asthma. Few data are available about its impact on lung function and on asthma comorbidities, long-term follow-up of treated patients, adherence, non-responders profile, and optimal treatment duration.OBJECTIVE: We aimed at evaluating o
  • PMID 24508951
  • Carboplatin-induced severe hypersensitivity reaction: the role of IgE-dependent basophil activation and FcεRI.
  • Iwamoto T1, Hirai H, Yamaguchi N, Kobayashi N, Sugimoto H, Tabata T, Okuda M.
  • Cancer science.Cancer Sci.2014 Sep 17. doi: 10.1111/cas.12538. [Epub ahead of print]
  • Basophil activation was observed in patients with a history of carboplatin-induced severe hypersensitivity reaction. However, the precise mechanism by which carboplatin induces basophil activation and the associated surrogate markers remain to be elucidated. To investigate whether IgE-dependent mech
  • PMID 25230301


  • Omalizumabの投与間隔短縮が有効であった重症持続型気管支喘息の1例
  • 安藤 克利,大国 義弘,小松 あきな,松沼 亮,中島 啓,浅井 信博,牧野 英記,金子 教宏
  • アレルギー 60(5), 604-609, 2011-05-30
  • … 症例は61歳男性.重症持続型気管支喘息にてPSL 5mg/日内服加療中であった.平成21年12月よりOmalizumabの投与を開始したところ,投与1〜2週目の臨床所見は著明に改善するも,投与後4週目より自覚症状が再燃した.さらに週単位での平均SABA使用回数も投与1-2週目の平均0.61回/日から4週目には平均0.95回/日へと増悪した.このため,平成22年4月よりOmaluzumabを3週間毎投与へと投与間隔を短縮したところ,投与間での症状再燃が消失し,ACTの …
  • NAID 110008661495
  • 抗IgEモノクローナル抗体 (オマリズマブ) が奏功した好酸球性中耳炎・副鼻腔炎例
  • 大島 英敏,川瀬 哲明,小林 俊光
  • 耳鼻咽喉科臨床 104(5), 319-323, 2011-05-01
  • Omalizumab, a monoclonal antibody to human IgE, is used to treat severe asthma and is reportedly effective in other allergic diseases. … We report a case of eosinophilic otitis media and sinusitis improved by omalizumab treatment. … A 66-year-old woman with severe asthma, eosinophilic otitis media, and sinusitis had omalizumab started to treat asthma. …
  • NAID 10027972553


Omalizumab (trade name Xolair, Roche/Genentech and Novartis) is a humanized antibody used to reduce sensitivity to inhaled or ingested allergens, especially in the control of moderate to severe allergic asthma which does not ...
【一般名】 オマリズマブ(遺伝子組換え) Omalizumab(genetical recombination) 【解説】 ヒト化マウス抗ヒトIgEモノクローナル抗体に由来する軽鎖(C1048H1609N278O350S6;分子量:23,895.03)と重鎖(C2204H3389N588O673S15 ...