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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/12 21:09:06」(JST)

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Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a socially troubling but benign condition, hypohidrosis can lead to hyperthermia, heat exhaustion, heat stroke and potentially death.^[1] An extreme case of hypohydrosis in which there is a complete absence of sweating and the skin is dry is termed anhidrosis.

Causes

Medications

Anticholinergic agents
Opioids
Botulinum toxin
Alpha-2 receptor antagonists
Clonidine
Barbiturates

Physical agents

Tumors
Burns
Radiation
Surgery
Scars
Sores

Dermatological

X-linked hypohidrotic ectodermal dysplasia
Incontinentia pigmenti
Bazex disease
Fabry disease
Miliaria
Sjogren syndrome
Systemic sclerosis
Graft-versus-host disease

Neuropathic

Multiple system atrophy
Dementia with Lewy bodies
Multiple sclerosis
Cerebrovascular accident
Tumour
Encephalitis
Cervical myelopathy
Diabetes mellitus
Guillain–Barre syndrome
Hereditary sensory and autonomic neuropathy
Alcoholism
Amyloidosis
Ross syndrome
Pure autonomic failure
Horner's syndrome

Diagnosis

Sweat is readily visualized by a topical indicator such as iodinated starch (minor test) or sodium alizarin sulphonate, both of which undergo a dramatic colour change when moistened by sweat. A thermoregulatory sweat test can evaluate the body’s response to a thermal stimulus by inducing sweating through a hot box ⁄ room, thermal blanket or exercise. Failure of the topical indicator to undergo a colour change during thermoregulatory sweat testing indicates hypohidrosis, and further tests may be required to localize the lesion.

Magnetic resonance imaging of the brain and ⁄ or spinal cord is the best modality for evaluation when the lesion is suspected to be localized to the central nervous system.

Skin biopsies are useful when anhidrosis occurs as part of a dermatological disorder. Biopsy results may reveal the sweat gland destruction, necrosis or fibrosis, in addition to the findings of the primary dermatological disorder.

Management

The treatment options for hypohidrosis and anhidrosis is limited. Those with hypohidrosis should avoid drugs that can aggravate the condition (see medication-causes). They should limit activities that raise the core body temperature and if exercises are to be performed, they should be supervised and be performed in a cool, sheltered and well-ventilated environment. In instances where the cause is known, treatment should be directed at the primary pathology. In autoimmune diseases, such as Sjogren syndrome and systemic sclerosis, treatment of the underlying disease using immunosuppressive drugs may lead to improvement in hypohidrosis. In neurological diseases, the primary pathology is often irreversible. In these instances, prevention of further neurological damage, such as good glycaemic control in diabetes, is the cornerstone of management. In acquired generalized anhidrosis, spontaneous remission may be observed in some cases. Numerous cases have been reported to respond effectively to systemic corticosteroids. Although an optimum dose and regime has not been established, pulse methylprednisolone (up to 1000 mg ⁄ day) has been reported to have good effect.

References

^ Chia, K. Y.; Tey, H. L. (2012). "Approach to hypohidrosis". Journal of the European Academy of Dermatology and Venereology 27 (7): 799–804. doi:10.1111/jdv.12014. PMID 23094789.

Notes

http://www.mayoclinic.com/health/anhidrosis/DS01050^{[full citation needed]}
MedlinePlus Encyclopedia Sweating - absent

English Journal

The management and treatment of children with Fabry disease: A United States-based perspective.

Hopkin RJ1, Jefferies JL2, Laney DA3, Lawson VH4, Mauer M5, Taylor MR6, Wilcox WR7; Fabry Pediatric Expert Panel.
Molecular genetics and metabolism.Mol Genet Metab.2015 Oct 23. pii: S1096-7192(15)30065-2. doi: 10.1016/j.ymgme.2015.10.007. [Epub ahead of print]
Fabry disease is an inherited X-linked disorder that presents during childhood in male and female patients. Young patients may initially experience pain, hypohidrosis, and gastrointestinal symptoms. Other manifestations of Fabry disease, such as renal and cardiac disease, manifest later in adolescen
PMID 26546059

FAM111B Mutation Is Associated With Inherited Exocrine Pancreatic Dysfunction.

Seo A1, Walsh T, Lee M, Ho P, Hsu EK, Sidbury R, King MC, Shimamura A.
Pancreas.Pancreas.2015 Oct 22. [Epub ahead of print]
OBJECTIVES: Few genetic causes of exocrine pancreatic dysfunction have been described to date. We identified a family with multiple affected members manifesting exocrine pancreatic dysfunction. Additional associated features included facial rash, sparse hair, hypohidrosis, and swelling of the extrem
PMID 26495788

Expanding the clinical spectrum of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis due to FAM111B mutations.

Mercier S1,2,3, Küry S4, Salort-Campana E5, Magot A6,7, Agbim U8, Besnard T9, Bodak N10, Bou-Hanna C11, Bréhéret F12, Brunelle P13, Caillon F14, Chabrol B15, Cormier-Daire V16, David A17, Eymard B18, Faivre L19,20, Figarella-Branger D21, Fleurence E22,23, Ganapathi M24, Gherardi R25, Goldenberg A26, Hamel A27, Igual J28, Irvine AD29,30,31, Israël-Biet D32, Kannengiesser C33, Laboisse C34,35, Le Caignec C36, Mahé JY37,38, Mallet S39, MacGowan S40,41, McAleer MA42,43, McLean I44, Méni C45, Munnich A46, Mussini JM47, Nagy PL48, Odel J49, O'Regan GM50, Péréon Y51,52, Perrier J53, Piard J54, Puzenat E55, Sampson JB56, Smith F57, Soufir N58, Tanji K59, Thauvin C60,61, Ulane C62, Watson RM63, Khumalo NP64, Mayosi BM65, Barbarot S66, Bézieau S67,68.
Orphanet journal of rare diseases.Orphanet J Rare Dis.2015 Oct 15;10:135. doi: 10.1186/s13023-015-0352-4.
BACKGROUND: Hereditary Fibrosing Poikiloderma (HFP) with tendon contractures, myopathy and pulmonary fibrosis (POIKTMP [MIM 615704]) is a very recently described entity of syndromic inherited poikiloderma. Previously by using whole exome sequencing in five families, we identified the causative gene,
PMID 26471370

Japanese Journal

Clinical experience with open-label topiramate use in epileptic children with CNS anomalies

, , , ,
Epilepsy & Seizure 3(1), 84-95, 2010
… The most common side effect was oligohidrosis (n=9, 41%).<BR><B>Conclusion:</B> …
NAID 130000255295

Ｚｏｎｉｓａｍｉｄｅによる発汗障害　アンケート調査による後方視的検討:アンケート調査による後方視的検討

伊住浩史,林隆,吉冨友美,西河美希,市山高志,古川漸
脳と発達 31(5), 468-470, 1999
近年zonisamide (ZNS) 投与による発汗障害が報告されている. 我々はアンケート調査およびカルテ記載から後方視的にその発症状況を検討した. 6カ月以上ZNSを内服している27名のうち12名 (44.4%) が発汗減少を感じたことがあった. 性差, ZNS血中濃度および併用抗けいれん薬との相関関係はみられなかった. 年齢差では6歳以上の学童児に比べ5歳以下の乳幼児に発汗減少の頻度が高い傾 …
NAID 130004183332

Heat stroke-like episode in child caused by zonisamide

SHIMIZU Toko,YAMASHITA Yushiro,SATOI Mika,TOGO Akiko,WADA Naoko,MATSUISHI Toyojiro,OHNISHI Akio,KATO Hirohisa
Brain & development 19(5), 366-368, 1997-07
NAID 10005962270

Related Pictures

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