FBXO4 loss facilitates carcinogen induced papilloma development in mice.
Lian Z1, Lee EK, Bass AJ, Wong KK, Klein-Szanto AJ, Rustgi AK, Diehl JA.
Cancer biology & therapy.Cancer Biol Ther.2015 May 4;16(5):750-5. doi: 10.1080/15384047.2015.1026512.
Cyclin D1 is frequently overexpressed in esophageal squamous cell carcinoma (ESCC) and is considered a key driver of this disease. Mutations in FBXO4, F-box specificity factor that directs SCF-mediated ubiquitylation of cyclin D1, occur in ESCC with concurrent overexpression of cyclin D1 suggesting
Nf1 Haploinsufficiency Alters Myeloid Lineage Commitment and Function, Leading to Deranged Skeletal Homeostasis.
Rhodes SD1,2, Yang H2,3, Dong R2,3, Menon K2,3, He Y2,3, Li Z2,3, Chen S2,3, Staser KW2,3, Jiang L2,3, Wu X2,3, Yang X2,3, Peng X4, Mohammad KS4, Guise TA4, Xu M2,3,5, Yang FC1.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.J Bone Miner Res.2015 Apr 27. doi: 10.1002/jbmr.2538. [Epub ahead of print]
Although nullizygous loss of NF1 leads to myeloid malignancies, haploinsufficient loss of NF1 (Nf1) has been shown to contribute to osteopenia and osteoporosis which occurs in approximately 50% of neurofibromatosis type 1 (NF1) patients. Bone marrow mononuclear cells of haploinsufficient NF1 patient
Distinct luminal-type mammary carcinomas arise from orthotopic Trp53-null mammary transplantation of juvenile versus adult mice.
Nguyen DH1, Ouyang H1, Mao JH2, Hlatky L3, Barcellos-Hoff MH4.
Cancer research.Cancer Res.2014 Dec 1;74(23):7149-58. doi: 10.1158/0008-5472.CAN-14-1440. Epub 2014 Oct 3.
Age and physiologic status, such as menopause, are risk factors for breast cancer. Less clear is what factors influence the diversity of breast cancer. In this study, we investigated the effect of host age on the distribution of tumor subtypes in mouse mammary chimera consisting of wild-type hosts a
Susceptibility of Heterozygous and Nullizygous p53 Knockout Mice to Chemical Carcinogens : Tissue Dependence and Role of p53 Gene Mutations
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Journal of toxicologic pathology 18(3), 121-134, 2005-09-30
Mutations of the p53 tumor suppressor gene constitute one of the most frequent molecular changes in a wide variety of human cancers and mice deficient in p53 have recently attracted attention for thei …
Tongue Carcinogenic Susceptibility of p53 Deficient Mice to Methyl-n-amylnitrosamine
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Journal of toxicologic pathology 15(4), 209-214, 2002-12-25
… In this study we investigated the susceptibility of p53 nullizygous (-/-), heterozygous (+/-), and wild type (+/+) mice to methyl-n-amylnitrosamine (MNAN) induced squamous cell carcinoma (SCC) of the tongue. …
Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype
nullizygous (not comparable) (genetics) Carrying two mutant alleles for the same gene, both alleles being complete loss-of-function or "null" alleles. Related terms [edit] nullizygote Retrieved from "https://en.wiktionary.org/w/index" : ...