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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/18 23:42:02」(JST)

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  • MNADK, a Long-Awaited Human Mitochondrion-Localized NAD Kinase.
  • Zhang R1.
  • Journal of cellular physiology.J Cell Physiol.2015 Aug;230(8):1697-701. doi: 10.1002/jcp.24926.
  • Nicotinamide adenine dinucleotide (NAD) and its phosphorylated form, NADP, play essential roles in numerous cellular processes in all organisms. NADP maintains a pool of its reducing equivalent, NADPH, which regenerates cellular oxidative defense systems to counteract oxidative damages. Mitochondria
  • PMID 25641397
  • Upregulation of microRNA‑492 induced by epigenetic drug treatment inhibits the malignant phenotype of clear cell renal cell carcinoma in vitro.
  • Wu A1, Wu K1, Li M1, Bao L1, Shen X1, Li S1, Li J1, Yang Z1.
  • Molecular medicine reports.Mol Med Rep.2015 Jul;12(1):1413-20. doi: 10.3892/mmr.2015.3550. Epub 2015 Mar 26.
  • Clear cell renal cell carcinoma (ccRCC) is the most common type of cancer of the renal parenchyma. MicroRNAs (miRNAs) are non‑coding RNAs of ~22 nucleotides in length, which function as post‑transcriptional regulators. Recently, the downregulation of miRNA (miR)‑492 was observed to be associa
  • PMID 25815441
  • Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.
  • Derissen EJ1, Hillebrand MJ2, Rosing H2, Schellens JH3, Beijnen JH4.
  • Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2015 Jun 10;110:58-66. doi: 10.1016/j.jpba.2015.02.051. Epub 2015 Mar 10.
  • 5-Fluorouracil (5-FU) and its oral prodrug capecitabine are among the most widely used chemotherapeutics. For cytotoxic activity, 5-FU requires cellular uptake and intracellular metabolic activation. Three intracellular formed metabolites are responsible for the antineoplastic effect of 5-FU: 5-fluo
  • PMID 25804433


  • イヌのグルコース輸送体4(GluT4)の分子構造と組織発現
  • 落合 秀治,吉村 彰紘,印牧 信行,佐藤 礼一郎,恩田 賢
  • 麻布大学雑誌 = Journal of Azabu University 26, 11-16, 2015-03-20
  • … Canine GluT4 was consisted of 1637 nucleotides encoding 510 amino acids, which is one amino acid longer than human and mouse. …
  • NAID 120005598383
  • cDNA cloning and characterization of a rhamnose-binding lectin SUL-I from the toxopneustid sea urchin Toxopneustes pileolus venom
  • Hatakeyama Tomomitsu,Ichise Ayaka,Yonekura Tomokazu,Unno Hideaki,Goda Shuichiro,Nakagawa Hideyuki
  • Toxicon 94, 8-15, 2015-02
  • … The SUL-I gene contains an open reading frame of 927 nucleotides corresponding to 308 amino acid residues, including 24 residues of a putative signal sequence. …
  • NAID 120005526604
  • Nutrients and non-volatile taste compounds in Chinese mitten crab by-products
  • Guo Yan-Ru,Gu Sai-Qi,Wang Xi-Chang [他]
  • Fisheries science 81(1), 193-203, 2015-01
  • NAID 40020352431


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noun Biochemistry. any of a group of molecules that, when linked together, form the building blocks of DNA or RNA: composed of a phosphate group, the bases adenine, cytosine, guanine, and thymine, and a pentose sugar, in RNA ...


Nucleotides and Bases - Genetics Nucleotides and BasesPyrimidine nucleotidesNucleotide - Wikidna nucleotides and bases rna nucleotides What is Three Parts of Nucleotide ? | DNA




  • 核酸塩基+糖+リン酸
  • ヌクレオシドの糖の部分に1個以上のリン酸基がエステル結合した物質


  • De novo pathway
アミノプテリンが途中の合成系路を阻害する ← モノクローナル抗体の作成における選抜に利用される (関:HAT培地)
  • Salvage pathway]
  • 2通りの経路がある
  • 1. thymidine→…→nucleptode
thymidine kinase(TK)が触媒
hupoxanthine guanine phosphoribosyl transferase(HGPRT)が関与


  [★] ヌクレオチド

WordNet   license wordnet

「a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA)」