WordNet
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
- a glycoside formed by partial hydrolysis of a nucleic acid
- the basic unit of money in Papua New Guinea
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/04 03:55:56」(JST)
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Nucleoside-diphosphate kinase |
Identifiers |
EC number |
2.7.4.6 |
CAS number |
9026-51-1 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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Nucleoside-diphosphate kinases (NDKs, also NDP Kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes that catalyze the exchange of phosphate groups between different nucleoside diphosphates. NDK activities maintain an equilibrium between the concentrations of different nucleoside triphosphates such as, for example, when GTP produced in the citric acid (Krebs) cycle is converted to ATP.[1]
Contents
- 1 Function
- 2 Prokaryotic systems
- 3 Eukaryotic systems
- 4 See also
- 5 References
- 6 External links
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Function [edit]
The overall effect of NDKs is to transfer a phosphate group from a nucleoside triphosphate to a nucleoside diphosphate. Starting with adenosine diphosphate GTP and ADP, the activity of NDK produces GDP and ATP.[1]
- GTP + ADP → GDP + ATP
Behind this apparently simple reaction is a multistep mechanism. The key steps are
- NDK binds a nucleoside triphosphate (NTP)
- NDK transfers a phosphate to itself, leaving a bound nucleoside diphosphate (NDP)
- NDK releases the bound nucloside diphosphate
- NDK binds another nucleoside diphosphate
- NDK transfers the phosphate to the diphosphate, creating a bound nucleoside triphosphate
- NDK releases the new nucleoside triphosphate
Each step is part of a reversible process, such that the multistep equilibrium is of the following form.
- NDK + NTP ↔ NDK~NTP ↔ NDK-P~NDP ↔ NDK-P + NDP
For the transfer of a phosphate from ATP to GDP, the reaction would proceed as
- NDK + ATP → NDK~ATP → NDK-P~ADP → NDK-P + ADP →
- NDK-P + GDP → NDK-P~GDP → NDK~GTP → NDK + GTP
Prokaryotic systems [edit]
Prokaryotic NDK forms a functional homotetramer.
Eukaryotic systems [edit]
There are two isoforms of NDK in humans: NDK-A and NDK-B. Both have very similar structure, and can combine in any proportion to form functional NDK hexamers.
See also [edit]
References [edit]
- ^ a b Berg, JM; JL Tymoczko, L Stryer (2002). Biochemistry - 5th Edition. WH Freeman and Company. p. 476. ISBN 0-7167-4684-0.
External links [edit]
- Nucleoside-Diphosphate Kinase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 2.7.4.6
Transferases: phosphorus-containing groups (EC 2.7)
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2.7.1-2.7.4:
phosphotransferase/kinase
(PO4) |
2.7.1: OH acceptor |
- Hexo-
- Gluco-
- Fructo-
- Galacto-
- Phosphofructo-
- 1
- Liver
- Muscle
- Platelet
- 2
- Riboflavin
- Shikimate
- Thymidine
- NAD+
- Glycerol
- Pantothenate
- Mevalonate
- Pyruvate
- Deoxycytidine
- PFP
- Diacylglycerol
- Phosphoinositide 3
- Class I PI 3
- Class II PI 3
- Sphingosine
- Glucose-1,6-bisphosphate synthase
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2.7.2: COOH acceptor |
- Phosphoglycerate
- Aspartate
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2.7.3: N acceptor |
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2.7.4: PO4 acceptor |
- Phosphomevalonate
- Adenylate
- Nucleoside-diphosphate
- Uridylate
- Guanylate
- Thiamine-diphosphate
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2.7.6: diphosphotransferase
(P2O7) |
- Ribose-phosphate diphosphokinase
- Thiamine diphosphokinase
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2.7.7: nucleotidyltransferase
(PO4-nucleoside) |
Polymerase |
DNA polymerase |
- DNA-directed DNA polymerase
- I
- II
- III
- IV
- V
- RNA-directed DNA polymerase
- Reverse transcriptase
- Telomerase
- DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase
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RNA nucleotidyltransferase |
- RNA polymerase/DNA-directed RNA polymerase
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- RNA polymerase IV
- Primase
- RNA-dependent RNA polymerase
- PNPase
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Phosphorolytic
3' to 5' exoribonuclease |
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Uridylyltransferase |
- Glucose-1-phosphate uridylyltransferase
- Galactose-1-phosphate uridylyltransferase
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Guanylyltransferase |
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Other |
- Recombinase (Integrase)
- Transposase
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2.7.8: miscellaneous |
Phosphatidyltransferases |
- CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
- CDP-diacylglycerol—serine O-phosphatidyltransferase
- CDP-diacylglycerol—inositol 3-phosphatidyltransferase
- CDP-diacylglycerol—choline O-phosphatidyltransferase
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Glycosyl-1-phosphotransferase |
- N-acetylglucosamine-1-phosphate transferase
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2.7.10-2.7.13: protein kinase
(PO4; protein acceptor) |
2.7.10: protein-tyrosine |
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2.7.11: protein-serine/threonine |
- see serine/threonine-specific protein kinases
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2.7.12: protein-dual-specificity |
- see serine/threonine-specific protein kinases
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2.7.13: protein-histidine |
- Protein-histidine pros-kinase
- Protein-histidine tele-kinase
- Histidine kinase
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 2.7.10
- 2.7.11-12
- 3.1
- 4.1
- 5.1
- 6.1-3
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Metabolism: amino acid metabolism · nucleotide enzymes
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Purine metabolism |
Anabolism
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R5P->IMP: Ribose-phosphate diphosphokinase · Amidophosphoribosyltransferase · Phosphoribosylglycinamide formyltransferase · AIR synthetase (FGAM cyclase) · Phosphoribosylaminoimidazole carboxylase · Phosphoribosylaminoimidazolesuccinocarboxamide synthase · IMP synthase
IMP->AMP: Adenylosuccinate synthase · Adenylosuccinate lyase · reverse (AMP deaminase)
IMP->GMP: IMP dehydrogenase · GMP synthase · reverse (GMP reductase)
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Nucleotide salvage
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Hypoxanthine-guanine phosphoribosyltransferase · Adenine phosphoribosyltransferase
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Catabolism
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Adenosine deaminase · Purine nucleoside phosphorylase · Guanine deaminase · Xanthine oxidase · Urate oxidase
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Pyrimidine metabolism |
Anabolism
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CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase)
Dihydroorotate dehydrogenase · Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase
CTP synthase
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Catabolism
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Dihydropyrimidine dehydrogenase · Dihydropyrimidinase/DPYS · Beta-ureidopropionase/UPB1
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Deoxyribonucleotides |
Ribonucleotide reductase · Nucleoside-diphosphate kinase · DCMP deaminase · Thymidylate synthase · Dihydrofolate reductase
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- Reduction of salt-requirement of halophilic nucleoside diphosphate kinase by engineering S-S bond.
- Ishibashi M, Uchino M, Arai S, Kuroki R, Arakawa T, Tokunaga M.SourceFaculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
- Archives of biochemistry and biophysics.Arch Biochem Biophys.2012 Sep 1;525(1):47-52. Epub 2012 Jun 5.
- Nucleoside diphosphate kinase (HsNDK) from extremely halophilic haloarchaeon, Halobacterium salinarum, requires salt at high concentrations for folding. A D148C mutant, in which Asp148 was replaced with Cys, was designed to enhance stability and folding in low salt solution by S-S bond. It showed in
- PMID 22683473
Japanese Journal
- Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells
- Omri Abdelfatteh E. L.,Han Junkyu,Abdrabbah Manef Ben,Isoda Hiroko
- Cytotechnology 64(3), 231-240, 2012-05
- … Results showed that these compounds modulated significant and different effects on the expression of 4 stress-related proteins: heat shock protein 90 α (Hsp90), Transitional endoplasmic reticulum ATPase (VCP/p97), Nucleoside diphosphate kinase (NDK), and Hypoxia up-regulated protein 1 (HYOU1)) at translational and post translational levels in PC12 cells and they downregulated the expression of Hsp47 activity in Chinese hamster transformed cells. …
- NAID 120004898306
- Physiological and Biochemical Characterization of Three Nucleoside Diphosphate Kinase Isozymes from Rice (Oryza sativa L.)
- Kihara Akihiko,Saburi Wataru,Wakuta Shinji [他],KIM Myung-Hee,HAMADA Shigeki,ITO Hiroyuki,IMAI Ryozo,MATSUI Hirokazu
- Bioscience, biotechnology, and biochemistry 75(9), 1740-1745, 2011-09-23
- … Nucleoside diphosphate kinase (NDPK) is a ubiquitous enzyme that catalyzes the transfer of the γ-phosphoryl group from a nucleoside triphosphate to a nucleoside diphosphate. …
- NAID 10029757211
Related Links
- Nucleoside-diphosphate kinases (NDKs, also NDP Kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes that catalyze the exchange of phosphate groups between different nucleoside diphosphates. NDK ...
- INTRODUCTION Nucleoside diphosphate kinase (NDP kinase; EC) 1 is a ubiquitous enzyme that exchanges a phosphate between a nucleoside triphosphate and a nucleoside diphosphate (, 1). The mechanism of the reaction involves ...
★リンクテーブル★
[★]
- 英
- nucleoside diphosphate kinase, nucleoside-diphosphate kinase
[★]
NM23ヌクレオシド二リン酸キナーゼ
[★]
[★]
二リン酸エステル、二リン酸塩、二リン酸
- 関
- bisphosphate、diphosphoric acid、pyrophosphate
[★]
キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase
[★]
ヌクレオシド
- 関
- N、nucleosidic