WordNet

of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
(weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
any of several fat-soluble organic compounds having as a basis 17 carbon atoms in four rings; many have important physiological effects
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion

PrepTutorEJDIC

『核の』,細胞核の / [『原子』]『核の』
ステロイド(脂肪溶解性の有機化合物の総称)
=sense organ / 受信装置
ホルモン

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1. 喘息におけるステロイド耐性のメカニズムおよび臨床的意義mechanisms and clinical implications of glucocorticoid resistance in asthma [show details]
… GCs bind to a cytoplasmic glucocorticoid receptor (GR or NR3C1), which is a member of the nuclear receptor superfamily,… Familial GC resistance due to a missense mutation of the glucocorticoid receptor (GR) hormone binding domain causes global insensitivity…
2. 甲状腺ホルモンの作用thyroid hormone action [show details]
…discussed elsewhere. The nuclear actions of triiodothyronine (T3) are dependent upon four factors: the availability of the hormone, thyroid hormone nuclear receptors (TRs), receptor cofactors, and DNA regulatory …
3. 肺サルコイドーシスの治療：グルココルチコイド剤を用いる初期治療treatment of pulmonary sarcoidosis initial therapy with glucocorticoids [show details]
… colony stimulating factor (GM-CSF). Glucocorticoids appear to exert their effects on sarcoid granulomas through transcriptional regulation of glucocorticoid-receptor target genes and also non-genomic signal …
4. 喘息における吸入ステロイドの分子学的影響molecular effects of inhaled glucocorticoid therapy in asthma [show details]
… and receptors. Such genes are switched on when a coactivator molecule (eg, CREB-binding protein) binds to a proinflammatory transcription factor (eg, nuclear factor-kappa B [NF-kB],… receptors, cytokines, adhesion molecules, and chemokines. The net effect is decreased inflammatory cell recruitment, survival, and accumulation. There are two types of glucocorticoid receptors (GR)…
5. ステロイドの中断glucocorticoid withdrawal [show details]
… latter case, one can give stress doses of glucocorticoids or, if time permits, test for the responsiveness of the adrenal with an adrenocorticotropic hormone (ACTH [cosyntropin]) stimulation test. …

English Journal

Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer.

Boonyaratanakornkit V1, Hamilton N2, Márquez-Garbán DC2, Pateetin P3, McGowan EM4, Pietras RJ2.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2018 May 5;466:51-72. doi: 10.1016/j.mce.2017.11.010. Epub 2017 Nov 14.
PMID 29146555

Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions.

Proietti CJ1, Cenciarini ME2, Elizalde PV2.
Steroids.Steroids.2018 May;133:75-81. doi: 10.1016/j.steroids.2017.12.015. Epub 2018 Jan 6.
PMID 29317254

Communication between genomic and non-genomic signaling events coordinate steroid hormone actions.

Wilkenfeld SR1, Lin C2, Frigo DE3.
Steroids.Steroids.2018 May;133:2-7. doi: 10.1016/j.steroids.2017.11.005. Epub 2017 Nov 16.
PMID 29155216

Japanese Journal

Dog Steroidogenic Factor-1: Molecular cloning and analysis of epigenetic regulation

SEKIYA Asato,TAKASAWA Ken,ARAI Yoshikazu,TORISU Shidow,NISHINO Koichiro
Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 82(6), 681-689, 2020
… <p>Steroidogenic factor 1 (SF-1) is a nuclear receptor that is important in steroid hormone production, and adrenal and gonad development. …
NAID 130007855327

細胞膜上性ステロイドホルモン受容体mPRεを介した代謝機能制御

渡辺啓太,大植隆司,木村郁夫
日本薬理学会年会要旨集 93(0), 1-SS-59, 2020
… <p>Progesterone is a sex steroid hormone synthesized by the ovary, and plays a pivotal role for reproductive functions such as ovulation and the maintenance of pregnancy. … Although these effects of progesterone have been implicated in nuclear progesterone receptors (PRs)-mediated classical signaling pathway, key pathways involved in non-classical progesterone signaling has been provided by the identification of membrane progesterone receptors (mPRα, mPRβ, mPRγ, mPRδ, and mPRε). …
NAID 130007811363

細胞膜上性ステロイドホルモン受容体mPRεを介した代謝機能制御

渡辺啓太,大植隆司,木村郁夫
日本薬理学会年会要旨集 93(0), 1-P-109, 2020
… <p>Progesterone is a sex steroid hormone synthesized by the ovary, and plays a pivotal role for reproductive functions such as ovulation and the maintenance of pregnancy. … Although these effects of progesterone have been implicated in nuclear progesterone receptors (PRs)-mediated classical signaling pathway, key pathways involved in non-classical progesterone signaling has been provided by the identification of membrane progesterone receptors (mPRα, mPRβ, mPRγ, mPRδ, and mPRε). …
NAID 130007811295