WordNet
- of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
- (weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
- constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
- of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- (biology) a taxonomic group ranking below an order but above a family
PrepTutorEJDIC
- 『核の』,細胞核の / [『原子』]『核の』
- =sense organ / 受信装置
UpToDate Contents
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- 1. 甲状腺ホルモンの作用 thyroid hormone action
- 2. 選択的エストロゲン受容体モジュレーターの作用機序 mechanisms of action of selective estrogen receptor modulators
- 3. 複合免疫不全 combined immunodeficiencies
- 4. 乳癌におけるホルモン受容体：臨床的有用性および検査精度向上のためのガイドラインの推奨 hormone receptors in breast cancer clinical utility and guideline recommendations to improve test accuracy
- 5. 急性前骨髄球性白血病の分子生物学 molecular biology of acute promyelocytic leukemia
English Journal
- Targeting truncated RXRα for cancer therapy.
- Zhang X1, Zhou H2, Su Y3.
- Acta biochimica et biophysica Sinica.Acta Biochim Biophys Sin (Shanghai).2016 Jan;48(1):49-59. doi: 10.1093/abbs/gmv104. Epub 2015 Oct 21.
- Retinoid X receptor-alpha (RXRα), a unique member of the nuclear receptor superfamily, is a well-established drug target, representing one of the most important targets for pharmacologic interventions and therapeutic applications for cancer. However, how RXRα regulates cancer cell growth and how R
- PMID 26494413
- Cloning, mRNA expression and transcriptional regulation of five retinoid X receptor subtypes in yellow catfish Pelteobagrus fulvidraco by insulin.
- Pan YX1, Luo Z2, Wu K1, Zhang LH1, Xu YH1, Chen QL1.
- General and comparative endocrinology.Gen Comp Endocrinol.2016 Jan 1;225:133-41. doi: 10.1016/j.ygcen.2015.10.010. Epub 2015 Nov 11.
- Retinoid X receptors (RXRs) are members of the nuclear receptor superfamily and mediate development, reproduction, homeostasis and cell differentiation processes in vertebrates. In this study, full-length cDNA sequences of five rxr subtypes from yellow catfish Pelteobagrus fulvidraco were cloned. Th
- PMID 26519760
- Detection of Endogenous Selective Estrogen Receptor Modulators such as 27-Hydroxycholesterol.
- Nelson ER1.
- Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1366:431-43. doi: 10.1007/978-1-4939-3127-9_34.
- The estrogen receptors (ERs) belong to the nuclear receptor superfamily, and as such act as ligand inducible transcription factors, mediating the effects of estrogens. However, their pharmacology is complex, having the ability to be differentially activated by ligands. Such ligands possess the abili
- PMID 26585155
Japanese Journal
- Fertility preservation in a family with a novel NR5A1 mutation
- Yagi Hiroko,Takagi Masaki,Kon Masafumi,Igarashi Maki,Fukami Maki,Hasegawa Yukihiro
- Endocrine Journal 62(3), 289-295, 2015
- … The common phenotype of nuclear receptor superfamily 5, group A, member 1 (NR5A1) gene mutations in 46,XY is gonadal dysgenesis without adrenal deficiency. …
- NAID 130005060861
- Roles of Xenobiotic Receptors in Vascular Pathophysiology
- Xiao Lei,Zhang Zihui,Luo Xiaoqin
- Circulation Journal 78(7), 1520-1530, 2014
- … The pregnane X receptor (PXR) and constitutive androstane receptor (CAR), 2 closely related and liver-enriched members of the nuclear receptor superfamily, and aryl hydrocarbon receptor (AhR), a nonnuclear receptor transcription factor (TF), are major receptors/TFs regulating the expression of genes for the clearance and detoxification of xenobiotics. …
- NAID 130004926969
- Fertility preservation in a family with a novel NR5A1 mutation
- Yagi Hiroko,Takagi Masaki,Kon Masafumi,Igarashi Maki,Fukami Maki,Hasegawa Yukihiro
- Endocrine Journal advpub(0), 2014
- … The common phenotype of nuclear receptor superfamily 5, group A, member 1 (NR5A1) gene mutations in 46,XY is gonadal dysgenesis without adrenal deficiency. …
- NAID 130004713045
Related Links
- Diversity of nuclear receptors Nuclear receptors form a superfamily of phylogenetically related proteins, with 21 genes in the complete genome of the fly Drosophila melanogaster (Adams et ...
- The nuclear hormone receptor (NR) superfamily complement in humans is composed of 48 genes with diverse roles in metabolic homeostasis, development, and detoxification. In general, NRs are strongly conserved between ...
Related Pictures
★リンクテーブル★
| リンク元 | 「核内受容体スーパーファミリー」「核内レセプタースーパーファミリー」 |
| 関連記事 | 「superfamily」「nuclear」「nuclear receptor」「receptor superfamily」 |
「核内受容体スーパーファミリー」
- 細胞質体に存在し、リガンドの結合により核内に移行してDNAに結合して転写を促進する
ドメイン構造
- N末端--A/B(制御領域)--C(DNA結合領域)--D(核移行シグナル)--E/F(リガンド結合領域)--C末端
受容体とリガンド
| 内分泌受容体 | リガンド | |
| 糖質コルチコイド受容体 | GRα | 糖質コルチコイド |
| 鉱質コルチコイド受容体 | MR | 鉱質コルチコイド |
| 黄体ホルモン受容体 | PR | プロゲステロン |
| 男性ホルモン受容体 | AR | テストステロン |
| 卵胞ホルモン受容体 | ERα, ERβ | エストロゲン |
| レチノイン酸受容体 | RARα, RARβ, RARγ | レチノイン酸 |
| レチノイドX受容体 | RXRα, RXRβ, RXRγ | |
| 甲状腺ホルモン受容体 | TRα, TRβ | 甲状腺ホルモン |
| ビタミンD3受容体 | VDR | ビタミンD |
「核内レセプタースーパーファミリー」
「superfamily」
[★] (機能は異なるが構造や配列が似た遺伝子の集団)スーパーファミリー、(分類学;動物の)上科
「nuclear」
- adj.
- 核の、(生物)細胞核の、(物理)原子核の