WordNet

of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
(weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

『核の』,細胞核の / [『原子』]『核の』
=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/26 10:21:40」(JST)

wiki en

[Wiki en表示]

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

Function

NCoA-2 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.^[1]^[2]

GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1).^[3]

Interactions

Nuclear receptor coactivator 2 has been shown to interact with:

AR,^[4]^[5]^[6]^[7]^[8]
ARNT,^[9]
BRCA1,^[10]^[11]
DDX17,^[12]
DDX5,^[12]
ESR1,^[12]^[7]^[13]^[14]^[15]
NR3C1,^[16]^[17]
PPFIA4,^[18]
PPARG,^[19]
RXRA,^[20]^[21]
SRA1,^[12] and
VDR.^[7]^[13]^[22]^[20]

References

^ Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H (1996). "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors". EMBO J 15 (14): 3667–75. PMC 452006. PMID 8670870.
^ Hong H, Kohli K, Garabedian MJ, Stallcup MR (1997). "GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors". Mol Cell Biol 17 (5): 2735–44. PMC 232124. PMID 9111344.
^ Bhandare R, Damera G, Banerjee A, Flammer JR, Keslacy S, Rogatsky I, Panettieri RA, Amrani Y, Tliba O (January 2010). "Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells". Am. J. Respir. Cell Mol. Biol. 42 (1): 9–15. doi:10.1165/rcmb.2009-0239RC. PMC 2809222. PMID 19805480.
^ Song LN, Coghlan M, Gelmann EP (2004). "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Mol. Endocrinol. 18 (1): 70–85. doi:10.1210/me.2003-0189. PMID 14593076.
^ Ishitani K, Yoshida T, Kitagawa H, Ohta H, Nozawa S, Kato S (2003). "p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor". Biochem. Biophys. Res. Commun. 306 (3): 660–5. doi:10.1016/S0006-291X(03)01021-0. PMID 12810069.
^ Wang Q, Udayakumar TS, Vasaitis TS, Brodie AM, Fondell JD (2004). "Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells". J. Biol. Chem. 279 (17): 17319–28. doi:10.1074/jbc.M400970200. PMID 14966121.
^ ^a ^b ^c He B, Wilson EM (2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
^ Bai S, He B, Wilson EM (2005). "Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction". Mol. Cell. Biol. 25 (4): 1238–57. doi:10.1128/MCB.25.4.1238-1257.2005. PMC 548016. PMID 15684378.
^ Beischlag TV, Wang S, Rose DW, Torchia J, Reisz-Porszasz S, Muhammad K, Nelson WE, Probst MR, Rosenfeld MG, Hankinson O (2002). "Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex". Mol. Cell. Biol. 22 (12): 4319–33. doi:10.1128/MCB.22.12.4319-4333.2002. PMC 133867. PMID 12024042.
^ Rodriguez M, Yu X, Chen J, Songyang Z (2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
^ Park JJ, Irvine RA, Buchanan G, Koh SS, Park JM, Tilley WD, Stallcup MR, Press MF, Coetzee GA (2000). "Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor". Cancer Res. 60 (21): 5946–9. PMID 11085509.
^ ^a ^b ^c ^d Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900.
^ ^a ^b Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
^ Wärnmark A, Treuter E, Gustafsson JA, Hubbard RE, Brzozowski AM, Pike AC (2002). "Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha". J. Biol. Chem. 277 (24): 21862–8. doi:10.1074/jbc.M200764200. PMID 11937504.
^ Fenne IS, Hoang T, Hauglid M, Sagen JV, Lien EA, Mellgren G (2008). "Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase". Endocrinology 149 (9): 4336–45. doi:10.1210/en.2008-0037. PMID 18499756.
^ Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA (2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Mol. Endocrinol. 15 (4): 501–11. doi:10.1210/mend.15.4.0624. PMID 11266503.
^ Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM, Lambert MH, Moore JT, Pearce KH, Xu HE (2002). "Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition". Cell 110 (1): 93–105. doi:10.1016/S0092-8674(02)00817-6. PMID 12151000.
^ Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron 34 (1): 39–52. doi:10.1016/S0896-6273(02)00640-2. PMID 11931740.
^ Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S (2000). "Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators". J. Biol. Chem. 275 (43): 33201–4. doi:10.1074/jbc.C000517200. PMID 10944516.
^ ^a ^b Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN (2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". J. Biol. Chem. 276 (44): 40614–20. doi:10.1074/jbc.M106263200. PMID 11514567.
^ Lee WY, Noy N (2002). "Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain". Biochemistry 41 (8): 2500–8. doi:10.1021/bi011764. PMID 11851396.
^ Herdick M, Steinmeyer A, Carlberg C (2000). "Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators". J. Biol. Chem. 275 (22): 16506–12. doi:10.1074/jbc.M910000199. PMID 10748178.

External links

nuclear receptor coactivator 2 at the US National Library of Medicine Medical Subject Headings (MeSH)
NURSA C90

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 甲状腺ホルモンの作用 thyroid hormone action
2. 選択的エストロゲン受容体モジュレーターの作用機序 mechanisms of action of selective estrogen receptor modulators
3. プロゲステロン受容体モジュレーター（PRM）の薬理学および作用機序 pharmacology and mechanism of action of progesterone receptor modulators prms
4. エストロゲン作用の分子生物学および生理学 molecular biology and physiology of estrogen action
5. 去勢抵抗性前立腺癌：アンドロゲンの作用経路を標的する療法 castration resistant prostate cancer treatments targeting the androgen pathway

English Journal

Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis.

Dasgupta S, Putluri N, Long W, Zhang B, Wang J, Kaushik AK, Arnold JM, Bhowmik SK, Stashi E, Brennan CA, Rajapakshe K, Coarfa C, Mitsiades N, Ittmann MM, Chinnaiyan AM, Sreekumar A, O'Malley BW.
The Journal of clinical investigation.J Clin Invest.2015 Mar 2;125(3):1174-88. doi: 10.1172/JCI76029. Epub 2015 Feb 9.
Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. The underlying regulators of the tumor metabolic program are not completely understood; however, these factors have potential as cancer th
PMID 25664849

Proteomic profiling reveals autoimmune targets in sarcoidosis.

Häggmark A1, Hamsten C, Wiklundh E, Lindskog C, Mattsson C, Andersson E, Lundberg IE, Grönlund H, Schwenk JM, Eklund A, Grunewald J, Nilsson P.
American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2015 Mar 1;191(5):574-83. doi: 10.1164/rccm.201407-1341OC.
RATIONALE: There is a need to further characterize the antibody repertoire in relation to sarcoidosis and potentially related autoantigens.OBJECTIVES: We investigated bronchoalveolar lavage (BAL) and serum samples from patients with sarcoidosis and healthy and diseased control subjects to discover s
PMID 25608002

PAX3-NCOA2 fusion gene has a dual role in promoting the proliferation and inhibiting the myogenic differentiation of rhabdomyosarcoma cells.

Yoshida H1, Miyachi M1, Sakamoto K1, Ouchi K1, Yagyu S1, Kikuchi K1, Kuwahara Y1, Tsuchiya K1, Imamura T1, Iehara T1, Kakazu N2, Hojo H3, Hosoi H1.
Oncogene.Oncogene.2014 Dec 4;33(49):5601-8. doi: 10.1038/onc.2013.491. Epub 2013 Nov 11.
We analyzed a complex chromosomal translocation in a case of embryonal rhabdomyosarcoma (RMS) and showed that it generates the fusion gene PAX3 (paired box 3)-NCOA2 (nuclear receptor coactivator 2). To understand the role of this translocation in RMS tumorigenesis, we established two types of stable
PMID 24213582

Japanese Journal

Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes

Acta Medica Okayama 70(3), 151-158, 2016-06
NAID 120005770682

IS-MW-3-1 Nuclear receptor coactivator-6 (Ncoa6) plays as a potent tumor suppressor of endometrial cancer(Group 3 Oncology 1,International Session Mini Workshop)

日本産科婦人科學會雜誌 68(2), 471, 2016-02-01
NAID 110010034528

Transcriptional regulation of genes related to progesterone production [Review]

Endocrine Journal 62(9), 757-763, 2015
NAID 130005100646

Related Pictures

★リンクテーブル★

リンク元	「核内受容体コアクチベーター2」「steroid receptor coactivator 2」「核内レセプター転写共役因子2」「核内レセプターコアクチベーター2」
関連記事	「nuclear」「nuclear receptor」

「核内受容体コアクチベーター2」

Nuclear receptor coactivator 2
	; Rendering of 1GWQ
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1GWQ, 1GWR, 1M2Z, 1MV9, 1MVC, 1MZN, 1P93, 1T63, 1T65, 1UHL, 1YOK, 1ZDT, 1ZDU, 1ZKY, 2AO6, 2B1V, 2B1Z, 2B23, 2FAI, 2G44, 2G5O, 2P15, 2P1T, 2P1U, 2P1V, 2Q7J, 2Q7L, 2ZXZ, 2ZY0, 3A9E, 3CLD, 3DZU, 3DZY, 3E00, 3E7C, 3E94, 3ERD, 3FUG, 3GN8, 3K22, 3K23, 3KWY, 3KYT, 3L0E, 3L0J, 3L0L, 3O1D, 3O1E, 3OAP, 3OZJ, 3PCU, 3PLZ, 3Q95, 3Q97, 3R5M, 3UP0, 3UP3, 4CSJ, 4DOS, 4E2J, 4FHH, 4FHI, 4IA1, 4IA2, 4IA3, 4IA7, 4IQR, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 4K4J, 4K6I, 4M8E, 4M8H, 4NIE, 4NQA, 4P6W, 4P6X, 4PP6, 4PPP, 4PPS
Identifiers
Symbols	NCOA2 ; GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75
External IDs	OMIM: 601993 MGI: 1276533 HomoloGene: 4768 ChEMBL: 1615341 GeneCards: NCOA2 Gene
Gene ontology
Molecular function	• chromatin binding; • transcription coactivator activity; • histone acetyltransferase activity; • signal transducer activity; • protein binding; • ligand-dependent nuclear receptor binding; • ligand-dependent nuclear receptor transcription coactivator activity; • thyroid hormone receptor coactivator activity; • nuclear hormone receptor binding; • protein dimerization activity;
Cellular component	• nucleoplasm; • cytoplasm;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • transcription, DNA-templated; • regulation of transcription, DNA-templated; • histone acetylation; • androgen receptor signaling pathway; • cellular lipid metabolic process; • small molecule metabolic process; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of receptor activity;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;