|
|
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (December 2015) |
|
|
The neutrality of this article is disputed. Relevant discussion may be found on the talk page. Please do not remove this message until conditions to do so are met. (November 2015) |
| Nosocomial infection |
|
Contaminated surfaces increase cross-transmission
|
| Classification and external resources |
| Specialty |
Infectious disease |
| ICD-10 |
Y95 |
| eMedicine |
article/967022 |
|
[edit on Wikidata]
|
Hospital-acquired infection (HAI) — also known as nosocomial infection — is an infection that is contracted from the environment or staff of a healthcare facility. It can be spread in the hospital environment, nursing home environment, rehabilitation facility, clinic,or other clinical settings. Infection is spread to the susceptible patient in the clinical setting by a number of means. Health care staff can spread infection, in addition to contaminated equipment, bed linens, or air droplets. The infection can originate from the outside environment, another infected patient, staff that may be infected, or in some cases, the source of the infection cannot be determined. In some cases the microorganism originates from the patient's own skin microbiota, becoming opportunistic after surgery or other procedures that compromise the protective skin barrier. Though the patient may have contracted the infection from their own skin, the infection is still considered nosocomial since it develops in the health care setting.
In the United States, the Centers for Disease Control and Prevention estimated roughly 1.7 million hospital-associated infections, from all types of microorganisms, including bacteria and fungi combined, cause or contribute to 99,000 deaths each year.[citation needed] In Europe, where hospital surveys have been conducted, the category of gram-negative infections are estimated to account for two-thirds of the 25,000 deaths each year. Nosocomial infections can cause severe pneumonia and infections of the urinary tract, bloodstream and other parts of the body. Many types are difficult to treat with antibiotics, and. In addition, antibiotic resistance can complicate treatment.
Contents
- 1 Types
- 2 Cause
- 3 Prevention
- 3.1 Sterilization
- 3.2 Isolation
- 3.3 Handwashing
- 3.4 Gloves
- 3.5 Surface sanitation
- 3.6 Antimicrobial surfaces
- 4 Treatment
- 5 Epidemiology
- 5.1 United States
- 5.2 France
- 5.3 Italy
- 5.4 United Kingdom
- 5.5 Switzerland
- 5.6 Finland
- 5.7 Belgium
- 6 History
- 7 See also
- 8 References
Types
- Hospital-acquired pneumonia
- Ventilator-associated pneumonia
- Urinary tract infection
- Gastroenteritis
- Puerperal fever
Organisms
- Staphylococcus aureus'
- Methicillin resistant Staphylococcus aureus[1]
- Candida albicans[1]
- Pseudomonas aeruginosa[1]
- Acinetobacter baumannii'[1]
- Stenotrophomonas maltophilia
- Clostridium difficile
- Escherichia coli[1]
- Tuberculosis
- Vancomycin-resistant Enterococcus
- Legionnaires' disease
Cause
Transmission
Indwelling catheters have recently been identified with hospital acquired infections. Procedures using Intravascular Antimicrobial Lock Therapy can reduce infections that are unexposed to blood-borne antibiotics. Introducing antibiotics, including ethanol, into the catheter (without flushing it into the bloodstream) reduces the formation of biofilms.[1]
Main routes of transmission
| Route |
Description |
| Contact transmission |
The most important and frequent mode of transmission of nosocomial infections is by direct contact. |
| Droplet transmission |
Transmission occurs when droplets containing microbes from the infected person are propelled a short distance through the air and deposited on the patient's body; droplets are generated from the source person mainly by coughing, sneezing, and talking, and during the performance of certain procedures, such as bronchoscopy. |
| Airborne transmission |
Dissemination can be either airborne droplet nuclei (small-particle residue {5 µm or smaller in size} of evaporated droplets containing microorganisms that remain suspended in the air for long periods of time) or dust particles containing the infectious agent. Microorganisms carried in this manner can be dispersed widely by air currents and may become inhaled by a susceptible host within the same room or over a longer distance from the source patient, depending on environmental factors; therefore, special air-handling and ventilation are required to prevent airborne transmission. Microorganisms transmitted by airborne transmission include Legionella, Mycobacterium tuberculosis and the rubeola and varicella viruses. |
| Common vehicle transmission |
This applies to microorganisms transmitted to the host by contaminated items, such as food, water, medications, devices, and equipment. |
| Vector borne transmission |
This occurs when vectors such as mosquitoes, flies, rats, and other vermin transmit microorganisms. |
Contact transmission is divided into two subgroups: direct-contact transmission and indirect-contact transmission.
Routes of contact transmission
| Route |
Description |
| Direct-contact transmission |
This involves a direct body surface-to-body surface contact and physical transfer of microorganisms between a susceptible host and an infected or colonized person, such as when a person turns a patient, gives a patient a bath, or performs other patient-care activities that require direct personal contact. Direct-contact transmission also can occur between two patients, with one serving as the source of the infectious microorganisms and the other as a susceptible host. |
| Indirect-contact transmission |
This involves contact of a susceptible host with a contaminated intermediate object, usually inanimate, such as contaminated instruments, needles, or dressings, or contaminated gloves that are not changed between patients. In addition, the improper use of saline flush syringes, vials, and bags has been implicated in disease transmission in the US, even when healthcare workers had access to gloves, disposable needles, intravenous devices, and flushes.[2] |
Prevention
Controlling nosocomial infection is to implement QA/QC measures to the health care sectors, and evidence-based management can be a feasible approach. For those with ventilator-associated or hospital-acquired pneumonia, controlling and monitoring hospital indoor air quality needs to be on agenda in management,[3] whereas for nosocomial rotavirus infection, a hand hygiene protocol has to be enforced.[4][5][6]
To reduce HAIs, the state of Maryland implemented the Maryland Hospital-Acquired Conditions Program that provides financial rewards and penalties for individual hospitals based on their ability to avoid HAIs. An adaptation of the Centers for Medicare & Medicaid Services payment policy causes poor-performing hospitals to lose up to 3% of their inpatient revenues, whereas hospitals that are able to avoid HAIs can earn up to 3% in rewards. During the program’s first 2 years, complication rates fell by 15.26 percent across all hospital-acquired conditions tracked by the state (including those not covered by the program), from a risk-adjusted complication rate of 2.38 per 1,000 people in 2009 to a rate of 2.02 in 2011. The 15.26-percent decline translates into more than $100 million in cost savings for the health care system in Maryland, with the largest savings coming from avoidance of urinary tract infections, septicemia and other severe infections, and pneumonia and other lung infections. If similar results could be achieved nationwide, the Medicare program would save an estimated $1.3 billion over 2 years, whereas the health care system as a whole would save $5.3 billion.[7]
Hospitals have sanitation protocols regarding uniforms, equipment sterilization, washing, and other preventive measures. Thorough hand washing and/or use of alcohol rubs by all medical personnel before and after each patient contact is one of the most effective ways to combat nosocomial infections.[8] More careful use of antimicrobial agents, such as antibiotics, is also considered vital.[9]
Despite sanitation protocol, patients cannot be entirely isolated from infectious agents. Furthermore, patients are often prescribed antibiotics and other antimicrobial drugs to help treat illness; this may increase the selection pressure for the emergence of resistant strains.[citation needed]
Sterilization
Sterilization goes further than just sanitizing. It kills all microorganisms on equipment and surfaces through exposure to chemicals, ionizing radiation, dry heat, or steam under pressure.[citation needed]
Isolation
Main article: Isolation (health care)
Isolation is the implementation of isolating precautions designed to prevent transmission of microorganisms by common routes in hospitals. (See Universal precautions and Transmission-based precautions.) Because agent and host factors are more difficult to control, interruption of transfer of microorganisms is directed primarily at transmission for example isolation of infectious cases in special hospitals and isolation of patient with infected wounds in special rooms also isolation of joint transplantation patients on specific rooms.
Handwashing
Handwashing frequently is called the single most important measure to reduce the risks of transmitting skin microorganisms from one person to another or from one site to another on the same patient. Washing hands as promptly and thoroughly as possible between patient contacts and after contact with blood, body fluids, secretions, excretions, and equipment or articles contaminated by them is an important component of infection control and isolation precautions. The spread of nosocomial infections, among immunocompromised patients is connected with health care workers' hand contamination in almost 40% of cases, and is a challenging problem in the modern hospitals. The best way for workers to overcome this problem is conducting correct hand-hygiene procedures; this is why the WHO launched in 2005 the GLOBAL Patient Safety Challenge.[10] Two categories of micro-organisms can be present on health care workers' hands: transient flora and resident flora. The first is represented by the micro-organisms taken by workers from the environment, and the bacteria in it are capable of surviving on the human skin and sometimes to grow. The second group is represented by the permanent micro-organisms living on the skin surface (on the stratum corneum or immediately under it). They are capable of surviving on the human skin and to grow freely on it. They have low pathogenicity and infection rate, and they create a kind of protection from the colonization from other more pathogenic bacteria. The skin of workers is colonized by 3.9 x 104 – 4.6 x 106 cfu/cm2. The microbes comprising the resident flora are: Staphylococcus epidermidis, S. hominis, and Microccocus, Propionibacterium, Corynebacterium, Dermobacterium, and Pitosporum spp., while in transient organisms are S. aureus, and Klebsiella pneumoniae, and Acinetobacter, Enterobacter and Candida spp. The goal of hand hygiene is to eliminate the transient flora with a careful and proper performance of hand washing, using different kinds of soap, (normal and antiseptic), and alcohol-based gels. The main problems found in the practice of hand hygiene is connected with the lack of available sinks and time-consuming performance of hand washing. An easy way to resolve this problem could be the use of alcohol-based hand rubs, because of faster application compared to correct hand-washing.[11]
All visitors must follow the same procedures as hospital staff to adequately control the spread of infections. Moreover, multidrug-resistant infections can leave the hospital and become part of the community flora if steps are not taken to stop this transmission.
It is unclear whether or not nail polish or rings affected surgical wound infection rates.[12]
Gloves
In addition to hand washing, gloves play an important role in reducing the risks of transmission of microorganisms. Gloves are worn for three important reasons in hospitals. First, they are worn to provide a protective barrier for personnel, preventing large scale contamination of the hands when touching blood, body fluids, secretions, excretions, mucous membranes, and non-intact skin. In the USA, the Occupational Safety and Health Administration has mandated wearing gloves to reduce the risk of bloodborne pathogen infections.[13] Second, gloves are worn to reduce the likelihood that microorganisms present on the hands of personnel will be transmitted to patients during invasive or other patient-care procedures that involve touching a patient's mucous membranes and nonintact skin. Third, they are worn to reduce the likelihood that the hands of personnel contaminated with micro-organisms from a patient or a fomite can transmit those micro-organisms to another patient. In this situation, gloves must be changed between patient contacts, and hands should be washed after gloves are removed.
Wearing gloves does not replace the need for handwashing, because gloves may have small, undtectable defects or may be torn during use, and hands can become contaminated during removal of gloves. Failure to change gloves between patient contacts is an infection control hazard.[citation needed]
Surface sanitation
Sanitizing surfaces is part of nosocomial infection in health care environments. Modern sanitizing methods such as Non-flammable Alcohol Vapor in Carbon Dioxide systems have been effective against gastroenteritis, MRSA, and influenza agents. Use of hydrogen peroxide vapor has been clinically proven to reduce infection rates and risk of acquisition. Hydrogen peroxide is effective against endospore-forming bacteria, such as Clostridium difficile, where alcohol has been shown to be ineffective.[14][non-primary source needed] Ultraviolet cleaning devices may also be used to disinfect the rooms of patients infected with Clostridium difficile after discharge.[15][non-primary source needed]
Antimicrobial surfaces
Micro-organisms are known to survive on inanimate ‘touch’ surfaces for extended periods of time.[16] This can be especially troublesome in hospital environments where patients with immunodeficiencies are at enhanced risk for contracting nosocomial infections.
Touch surfaces commonly found in hospital rooms, such as bed rails, call buttons, touch plates, chairs, door handles, light switches, grab rails, intravenous poles, dispensers (alcohol gel, paper towel, soap), dressing trolleys, and counter and table tops are known to be contaminated with Staphylococcus, MRSA (one of the most virulent strains of antibiotic-resistant bacteria) and vancomycin-resistant Enterococcus (VRE).[17] Objects in closest proximity to patients have the highest levels of MRSA and VRE. This is why touch surfaces in hospital rooms can serve as sources, or reservoirs, for the spread of bacteria from the hands of healthcare workers and visitors to patients.
A number of compounds can decrease the risk of bacteria growing on surfaces including: copper, silver, and germicides.[18]
Treatment
Among the categories of bacteria most known to infect patients are the category MRSA (resistant strain of S. aureus), member of gram-positive bacteria and Acinetobacter (A. baumannii), which is gram-negative. While antibiotic drugs to treat diseases caused by gram-positive MRSA are available, few effective drugs are available for Acinetobacter. Acinetobacter bacteria are evolving and becoming immune to existing antibiotics, so in many cases, polymyxin-type antibacterials need to be used. "In many respects it’s far worse than MRSA," said a specialist at Case Western Reserve University.[19]
Another growing disease, especially prevalent in New York City hospitals, is the drug-resistant, gram-negative Klebsiella pneumoniae. An estimated more than 20% of the Klebsiella infections in Brooklyn hospitals "are now resistant to virtually all modern antibiotics, and those supergerms are now spreading worldwide.[19]
The bacteria, classified as gram-negative because of their reaction to the Gram stain test, can cause severe pneumonia and infections of the urinary tract, bloodstream, and other parts of the body. Their cell structures make them more difficult to attack with antibiotics than gram-positive organisms like MRSA. In some cases, antibiotic resistance is spreading to gram-negative bacteria that can infect people outside the hospital. "For gram-positives we need better drugs; for gram-negatives we need any drugs," said Dr. Brad Spellberg, an infectious-disease specialist at Harbor-UCLA Medical Center, and the author of Rising Plague, a book about drug-resistant pathogens.[19]
One-third of nosocomial infections are considered preventable. The CDC estimates 2 million people in the United States are infected annually by hospital-acquired infections, resulting in 20,000 deaths.[20] The most common nosocomial infections are of the urinary tract, surgical site and various pneumonias.[21]
Epidemiology
The methods used differ from country to country (definitions used, type of nosocomial infections covered, health units surveyed, inclusion or exclusion of imported infections, etc.), so the international comparisons of nosocomial infection rates should be made with the utmost care.
United States
The Centers for Disease Control and Prevention (CDC) estimated roughly 1.7 million hospital-associated infections, from all types of bacteria combined, cause or contribute to 99,000 deaths each year.[22] Other estimates indicate 10%, or 2 million, patients a year become infected, with the annual cost ranging from $4.5 billion to $11 billion. In the USA, the most frequent type of infection hospitalwide is urinary tract infection (36%), followed by surgical site infection (20%), and bloodstream infection and pneumonia (both 11%).[19][needs update]
France
Estimates ranged from 6.7% in 1990 to 7.4% (patients may have several infections).[23] At national level, prevalence among patients in health care facilities was 6.7% in 1996,[24] 5.9% in 2001[25] and 5.0% in 2006.[26] The rates for nosocomial infections were 7.6% in 1996, 6.4% in 2001 and 5.4% in 2006.
In 2006, the most common infection sites were urinary tract infections (30,3%), pneumopathy (14,7%), infections of surgery site (14,2%). Infections of the skin and mucous membrane (10,2%), other respiratory infections (6,8%) and bacterial infections / blood poisoning (6,4%).[27] The rates among adult patients in intensive care were 13,5% in 2004, 14,6% in 2005, 14,1% in 2006 and 14.4% in 2007.[28]
Nosocomial infections are estimated to make patients stay in the hospital four to five additional days. Around 2004-2005, about 9,000 people died each year with a nosocomial infection, of which about 4,200 would have survived without this infection.[29]
Italy
Since 2000, estimates show about a 6.7% infection rate, i.e. between 450,000 and 700,000 patients, which caused between 4,500 and 7,000 deaths.[30] A survey in Lombardy gave a rate of 4.9% of patients in 2000.[31]
United Kingdom
In 2012 the Health Protection Agency reported the prevalence rate of HAIs in England was 6.4% in 2011, against a rate of 8.2% in 2006.[32] With respiratory tract, urinary tract and surgical site infections the most common types of HAI reported.[32]
Switzerland
Estimates range between 2 and 14%.[33] A national survey gave a rate of 7.2% in 2004.[34]
Finland
Rate were estimated at 8.5% of patients in 2005.[35]
Belgium
In Belgium the prevalence of nosocomial infections is about 6.2%. Annually about 125 500 patients become infected by a nosocomial infection, resulting in almost 3000 deaths. The extra costs for the health insurance are estimated to be approximately €400 million/year.[36]
History
mortality rates 1841-1846 in two clinics documented by Semmelweis
In 1841, Ignaz Semmelweis, a Hungarian obstetrician was working at a Vienna maternity hospital. He was "shocked" by the death rate of women who developed puerperal fever. He documented that the infection was 20 times higher in the ward where the medical students were delivering babies than in the next ward that was staffed by midwifery students. The medical students were also routinely working with cadavers. He compared the rates of infection with a similar hospital in Dublin, Ireland and hypothesized that it was the medical students who somehow were infecting the women after labor. He instituted mandatory hand-washing in May, 1847 and infection rates dropped dramatically. Louis Pasteur proposed the germ theory of disease and began his work on cholera in 1865 by identifying that it was microorganisms that were associated with disease.[37][38]
See also
- Cubicle curtain
- Infection control
- Iatrogenesis
- NAV-CO2
- Phototherapy
- Sanitation Standard Operating Procedures
References
- ^ a b c d e f Akbari, Freshta; Kjellerup, Birthe (2015). "Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters". Pathogens 4 (3): 457–469. doi:10.3390/pathogens4030457. ISSN 2076-0817.
- ^ Jain SK, Persaud D, Perl TM, et al. (July 2005). "Nosocomial malaria and saline flush". Emerging Infect. Dis. 11 (7): 1097–9. doi:10.3201/eid1107.050092. PMC 3371795. PMID 16022788.
- ^ Leung M, Chan AH (March 2006). "Control and management of hospital indoor air quality". Med. Sci. Monit. 12 (3): SR17–23. PMID 16501436.
- ^ Chan PC, Huang LM, Lin HC, et al. (April 2007). "Control of an outbreak of pandrug-resistant Acinetobacter baumannii colonization and infection in a neonatal intensive care unit". Infect Control Hosp Epidemiol 28 (4): 423–9. doi:10.1086/513120. PMID 17385148.
- ^ Traub-Dargatz JL, Weese JS, Rousseau JD, Dunowska M, Morley PS, Dargatz DA (July 2006). "Pilot study to evaluate 3 hygiene protocols on the reduction of bacterial load on the hands of veterinary staff performing routine equine physical examinations". Can. Vet. J. 47 (7): 671–6. PMC 1482439. PMID 16898109.
- ^ Katz JD (September 2004). "Hand washing and hand disinfection: more than your mother taught you". Anesthesiol Clin North America 22 (3): 457–71, vi. doi:10.1016/j.atc.2004.04.002. PMID 15325713.
- ^ "Statewide, All-Payer Financial Incentives Significantly Reduce Hospital-Acquired Conditions in Maryland Hospitals". Agency for Healthcare Research and Quality. 2013-07-03. Retrieved 2013-07-06.
- ^ McBryde ES, Bradley LC, Whitby M, McElwain DL (October 2004). "An investigation of contact transmission of methicillin-resistant Staphylococcus aureus". J. Hosp. Infect. 58 (2): 104–8. doi:10.1016/j.jhin.2004.06.010. PMID 15474180.
- ^ Lautenbach E (2001). "Chapter 14. Impact of Changes in Antibiotic Use Practices on Nosocomial Infections and Antimicrobial Resistance—Clostridium difficile and Vancomycin-resistant Enterococcus (VRE)". In Markowitz AJ. Making Health Care Safer: A Critical Analysis of Patient Safety Practices. Agency for Healthcare Research and Quality.
- ^ World Alliance for patient safety. WHO Guidelines on Hand Hygiene in Health Care. http://www.who.int/rpc/guidelines/9789241597906/en/. 2009
- ^ Hugonnet S, Perneger TV, Pittet D. Alcohol based hand rub improves compliance with hand hygiene in intensive care units. Arch Intern med 2002; 162: 1037-1043.
- ^ Arrowsmith, VA; Taylor, R (Aug 4, 2014). "Removal of nail polish and finger rings to prevent surgical infection.". The Cochrane database of systematic reviews 8: CD003325. doi:10.1002/14651858.CD003325.pub3. PMID 25089848.
- ^ "Occupational Exposure to Bloodborne Pathogens;Needlestick and Other Sharps Injuries; Final Rule. - 66:5317-5325". Osha.gov. Retrieved 2011-07-11.
- ^ Otter JA, French GL (January 2009). "Survival of nosocomial bacteria and spores on surfaces and inactivation by hydrogen peroxide vapor". J. Clin. Microbiol. 47 (1): 205–7. doi:10.1128/JCM.02004-08. PMC 2620839. PMID 18971364.
- ^ "Performance Feedback, Ultraviolet Cleaning Device, and Dedicated Housekeeping Team Significantly Improve Room Cleaning, Reduce Potential for Spread of Common, Dangerous Infection". Agency for Healthcare Research and Quality. 2014-01-15. Retrieved 2014-01-20.
- ^ Wilks, S.A., Michels, H., Keevil, C.W., 2005, The Survival of Escherichia Coli O157 on a Range of Metal Surfaces, International Journal of Food Microbiology, Vol. 105, pp. 445–454. and Michels, H.T. (2006), Anti-Microbial Characteristics of Copper, ASTM Standardization News, October, pp. 28-31
- ^ U.S. Department of Defense-funded clinical trials, as presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Washington, D.C., October 28, 2008
- ^ Weber, DJ; Rutala, WA (May 2013). "Self-disinfecting surfaces: review of current methodologies and future prospects.". American journal of infection control 41 (5 Suppl): S31–5. doi:10.1016/j.ajic.2012.12.005. PMID 23622745.
- ^ a b c d Pollack, Andrew. "Rising Threat of Infections Unfazed by Antibiotics" New York Times, Feb. 27, 2010
- ^ Ricks, Delthia (2007). "Germ Warfare". Ms. Magazine: 43–5.
- ^ Klevens RM, Edwards JR, Richards CL, et al. (2007). "Estimating health care-associated infections and deaths in U.S. hospitals, 2002". Public Health Rep 122 (2): 160–6. PMC 1820440. PMID 17357358.
- ^ Klevens, R Monina et al. "Estimating Health Care-associated Infections and Deaths in U.S. Hospitals, 2002." Public Health Reports 122.2 (2007): 160–166.
- ^ Quenon JL, Gottot S, Duneton P, Lariven S, Carlet J, Régnier B, Brücker G. Enquête nationale de prévalence des infections nosocomiales en France : Hôpital Propre (octobre 1990). BEH n° 39/1993.
- ^ Comité technique des infections nosocomiales (CTIN), Cellule infections nosocomiales, CClin Est, CClin Ouest, CClin Paris-Nord, CClin Sud-Est, CClin Sud-Ouest, avec la participation de 830 établissements de santé. Enquête nationale de prévalence des infections nosocomiales,1996, BEH n° 36/1997, 2 sept. 1997, 4 pp.. Résumé.
- ^ Lepoutre A, Branger B, Garreau N, Boulétreau A, Ayzac L, Carbonne A, Maugat S, Gayet S, Hommel C, Parneix P, Tran B pour le Réseau d’alerte, d’investigation et de surveillance des infections nosocomiales (Raisin). Deuxième enquête nationale de prévalence des infections nosocomiales, France, 2001, Surveillance nationale des maladies infectieuses, 2001-2003. Institut de veille sanitaire, sept. 2005, 11 pp. Résumé.
- ^ Institut de veille sanitaire Enquête nationale de prévalence des infections nosocomiales, France, juin 2006, Volume 1 – Méthodes, résultats, perspectives, mars 2009, ii + 81 pp. Volume 2 – Annexes, mars 2009, ii + 91 pp. Synthèse des résultats, Mars 2009, 11 pp.
- ^ Institut de veille sanitaire Enquête nationale de prévalence des infections nosocomiales, France, juin 2006, Vol. 1, Tableau 31, p. 24.
- ^ Réseau REA-Raisin « Surveillance des infections nosocomiales en réanimation adulte. France, résultats 2007 », Institut de veille sanitaire, Sept. 2009, ii + 60 pp.
- ^ Vasselle, Alain « Rapport sur la politique de lutte contre les infections nosocomiales », Office parlementaire d'évaluation des politiques de santé, juin 2006, 290 pp. (III.5. Quelle est l’estimation de la mortalité attribuable aux IN ?).
- ^ L'Italie scandalisée par "l'hôpital de l'horreur", Éric Jozsef, Libération, January 17, 2007 (French)
- ^ Liziolia A, Privitera G, Alliata E, Antonietta Banfi EM, Boselli L, Panceri ML, Perna MC, Porretta AD, Santini MG, Carreri V. Prevalence of nosocomial infections in Italy: result from the Lombardy survey in 2000. J Hosp Infect 2003;54:141-8.
- ^ a b "English National Point Prevalence Survey on Healthcare-associated Infections and Antimicrobial Use, 2011" (PDF). Health Protection Agency. Retrieved 28 November 2015.
- ^ Facts sheet - Swiss Hand Hygiene Campaign. (.doc)
- ^ Sax H, Pittet D pour le comité de rédaction de Swiss-NOSO et le réseau Swiss-NOSO Surveillance. Résultats de l’enquête nationale de prévalence des infections nosocomiales de 2004 (snip04). Swiss-NOSO 2005;12(1):1-4. Archived November 11, 2007 at the Wayback Machine
- ^ Lyytikainen O, Kanerva M, Agthe N, Mottonen T and the Finish Prevalence Survey Study Group. National Prevalence Survey on Nosocomial Infections in Finnish Acute Care Hospitals, 2005. 10th Epiet Scientific Seminar. Mahon, Menorca, Spain, 13–15 October 2005 [Poster].
- ^ Federaal Kenniscentrum voor de Gezondheidszorg (2009) Nosocomiale Infecties in België, deel II: Impact op Mortaliteit en Kosten. KCE-rapport 102A.
- ^ Pommerville, Jeffrey (2014). Fundamentals of microbiology. Burlington, MA: Jones & Bartlett Learning. ISBN 9781449647964.
- ^ "The prophet of bacteriology: Ignac Semmelweis (1818-1865)". Retrieved 2015-11-28; archived content from, The Wayback Machine; Infect Control. 1983 Sep-Oct;4(5):367-70.
|
Look up nosocomial in Wiktionary, the free dictionary. |
|
Medical harm
|
|
| Concepts |
- Iatrogenesis
- Medical malpractice
- Medical error
- Patient safety
- Medical debt
- Unnecessary health care
- Adverse effect (medicine)
- Patient abuse
|
|
| Related concerns |
- Adverse drug reaction
- Hospital-acquired pneumonia
- Hospital-acquired infection
- Hand washing
|
|
| Records and histories |
|
|
|
Intensive care medicine
|
|
- Health science
- Medicine
- Medical specialities
- Respiratory therapy
|
|
| General terms |
- Intensive care unit (ICU)
- Neonatal intensive care unit (NICU)
- Pediatric intensive care unit (PICU)
- Coronary care unit (CCU)
- Critical illness insurance
|
|
| Conditions |
|
Organ system failure
|
- Shock sequence
- SIRS
- Sepsis
- Severe sepsis
- Septic shock
- Multiple organ dysfunction syndrome
- Other shock
- Cardiogenic shock
- Distributive shock
- Anaphylaxis
- Obstructive shock
- Neurogenic shock
- Spinal shock
- Organ failure
- Acute renal failure
- Acute respiratory distress syndrome
- Acute liver failure
- Respiratory failure
- Multiple organ dysfunction syndrome
- Neonatal infection
- Polytrauma
- Coma
|
|
|
Complications
|
- Critical illness polyneuropathy / myopathy
- Critical illness–related corticosteroid insufficiency
- Decubitus ulcers
- Fungemia
- Stress hyperglycemia
- Stress ulcer
|
|
|
Iatrogenesis
|
- Methicillin-resistant Staphylococcus aureus
- Oxygen toxicity
- Refeeding syndrome
- Ventilator-associated lung injury
- Ventilator-associated pneumonia
|
|
|
| Diagnosis |
- Arterial blood gas
- Catheter
- Arterial line
- Central venous catheter
- Pulmonary artery catheter
- Blood cultures
- Screening cultures
|
|
| Life supporting treatments |
- Airway management
- Chest tube
- Dialysis
- Enteral feeding
- Goal-directed therapy
- Induced coma
- Mechanical ventilation
- Therapeutic hypothermia
- Total parenteral nutrition
- Tracheal intubation
|
|
| Drugs |
- Analgesics
- Antibiotics
- Antithrombotics
- Inotropes
- Intravenous fluids
- Neuromuscular-blocking drugs
- Recombinant activated protein C
- Sedatives
- Stress ulcer prevention drugs
- Vasopressors
|
|
| ICU scoring systems |
- APACHE II
- Glasgow Coma Scale
- PIM2
- SAPS II
- SAPS III
- SOFA
|
|
| Physiology |
- Hemodynamics
- Hypotension
- Level of consciousness
- Acid-base imbalance
- Water-electrolyte imbalance
|
|
| Organisations |
- Society of Critical Care Medicine
- Surviving Sepsis Campaign
- European Society of Paediatric and Neonatal Intensive Care
|
|
| Related specialties |
- Anesthesia
- Cardiology
- Internal medicine
- Neurology
- Pediatrics
- Pulmonology
- Surgery
- Traumatology
|
|
|
Drug reactions (Y40-Y59, E930-E949)
|
|
Adverse drug reaction/
drug eruption |
- antibiotics: Penicillin drug reaction
- Sulfonamide hypersensitivity syndrome
- Urticarial erythema multiforme
- Adverse effects of fluoroquinolones
- hormones: Steroid acne
- Steroid folliculitis
- chemotherapy: Chemotherapy-induced acral erythema
- Chemotherapy-induced hyperpigmentation
- Scleroderma-like reaction to taxanes
- Hydroxyurea dermopathy
- Exudative hyponychial dermatitis
- blood: Anticoagulant-induced skin necrosis
- Warfarin necrosis
- Vitamin K reaction
- Texier's disease
- anticonvulsant: Anticonvulsant hypersensitivity syndrome
- water-balance/acid-base: Allopurinol hypersensitivity syndrome
- pulmonary: Leukotriene receptor antagonist-associated Churg–Strauss syndrome
- vaccine: Eczema vaccinatum
- other specified agents: Adverse reaction to biologic agents
- Adverse reaction to cytokines
- Bromoderma
- Halogenoderma
- Iododerma
- Red man syndrome
- Methotrexate-induced papular eruption
- unspecified agent: Acute generalized exanthematous pustulosis
- Bullous drug reaction
- Drug-induced acne
- Drug-induced angioedema
- Drug-related gingival hyperplasia
- Drug-induced lichenoid reaction
- Drug-induced lupus erythematosus
- Drug-induced nail changes
- Drug-induced pigmentation
- Drug-induced pseudolymphoma
- Drug-induced urticaria
- Fixed drug reaction
- Stevens–Johnson syndrome
- Injection site reaction
- Linear IgA bullous dermatosis
- Toxic epidermal necrolysis
- HIV disease-related drug reaction
- Photosensitive drug reaction
- Serum sickness-like reaction
|
|
