正球性貧血
WordNet
- a deficiency of red blood cells (同)anaemia
- a lack of vitality (同)anaemia
- genus of terrestrial or lithophytic ferns having pinnatifid fronds; chiefly of tropical America (同)genus Anemia
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/28 20:05:35」(JST)
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Normocytic anemia is a common issue that occurs for men and women typically over 85 years old. Its prevalence increases with age, reaching 44 percent in men older than 85 years.[1]
Contents
- 1 Classification
- 2 Causes
- 3 References
- 4 External links
Classification
A normocytic anemia is defined as an anemia with a mean corpuscular volume (MCV) of 80-100 which is the normal range. However, the hematocrit and hemoglobin is decreased.[1]
Causes
The issue is thought of as representing any of the following:
- a decreased production of normal-sized red blood cells (e.g., anemia of chronic disease, aplastic anemia);
- an increased production of HbS as seen in sickle cell disease (not sickle cell trait);
- an increased destruction or loss of red blood cells (e.g., hemolysis, posthemorrhagic anemia);
- an uncompensated increase in plasma volume (e.g., pregnancy, fluid overload);
- a B2 (riboflavin) deficiency[2]
- a B6 (pyridoxine) deficiency[2]
- or a mixture of conditions producing microcytic and macrocytic anemia.[1]
Blood loss, suppressed production of RBCs or hemolysis represent most cases of normocytic anemia. In blood loss, morphologic findings are generally unremarkable except after 12 to 24 hrs where polychromasia appears. For reduced production of RBCs, like with low erythropoietin, the RBC morphology is unremarkable.[3] Patients with disordered RBC production, e.g. myelodysplastic syndrome, may have a dual population of elliptocytes, teardrop cells, or other poikilocytes as well as a nucleated RBCs. Hemolysis will often demonstrate poikilocytes specific to a cause or mechanism. E.g. Bite cells and/or blistor cells for oxidative hemolysis, Acanthocytes for pyruvate kinase deficiency or McLeod phenotype, Sickle cells for sickle cell anemia, Spherocytes for immune-mediated hemolysis or hereditary spherocytosis, Elliptocytosis for iron deficiency or hereditary elliptocytosis and schistocytes for intravascular hemolysis. Many hemolytic anemias show multiple poikilocytes such as G6PD deficiency which may show blister and bites cells as well as shistocytes. Neonatal hemolysis may not follow the classic patterns as in adults[3]
References
- ^ a b c Brill JR, Baumgardner DJ (November 2000). "Normocytic anemia". Am Fam Physician 62 (10): 2255–64. PMID 11126852.
- ^ a b Medical Physiolgy by Kibble and Halsey p295
- ^ a b Ford, J. (June 2013). "Red blood cell morphology". International Journal of Laboratory Hematology 35 (3): 351–357. doi:10.1111/ijlh.12082.
External links
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Diseases of red blood cells (D50–69,74, 280–287)
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Red
blood cells |
| ↑ |
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| ↓ |
| Anemia |
| Nutritional |
- Micro-: Iron-deficiency anemia
- Macro-: Megaloblastic anemia
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Hemolytic
(mostly normo-) |
| Hereditary |
- enzymopathy: G6PD
- glycolysis
- hemoglobinopathy: Thalassemia
- Sickle-cell disease/trait
- HPFH
- membrane: Hereditary spherocytosis
- Minkowski–Chauffard syndrome
- Hereditary elliptocytosis
- Southeast Asian ovalocytosis
- Hereditary stomatocytosis
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| Acquired |
- Drug-induced autoimmune
- Drug-induced nonautoimmune
- Hemolytic disease of the newborn
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Aplastic
(mostly normo-) |
- Hereditary: Fanconi anemia
- Diamond–Blackfan anemia
- Acquired: PRCA
- Sideroblastic anemia
- Myelophthisic
|
|
| Blood tests |
- MCV
- Normocytic
- Microcytic
- Macrocytic
- MCHC
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| Other |
- Methemoglobinemia
- Sulfhemoglobinemia
- Reticulocytopenia
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UpToDate Contents
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English Journal
- Presentation of hemolytic and hemorrhagic rangeliosis in Cerdocyon thous.
- Copat B, Bastiani PV, Castellarin Jaconi F, Wallyson Damarem W, Streck AF, de Oliveira EC, Sonne L, França RT.
- Ticks and tick-borne diseases. 2019 04;10(3)690-693.
- Rangeliosis, caused by protozoan Rangelia vitalii, is transmitted by the tick Amblyomma aureolatum. The disease is characterized by hemolytic and hemorrhagic disorder and has been described in dogs and other wild canids. The aim of this study was to compare clinicopathological findings and laborator
- PMID 30852178
- B-cell non-Hodgkin lymphoma discovery after observation of a platelet satellitism around atypical lymphocytes.
- Gatignol A, Amirault M, Legac É, Decker J.
- Annales de biologie clinique. 2019 Mar;().
- We report the case of an 83-year-old woman admitted to the accident and emergency unit for pneumopathy. The blood cell count on the DXH automaton (Coulter® ™ UniCel® DxH) found a normochromic and normocytic anemia, anormal platelet count and subnormal leukocyte formula. The only alarm raised by
- PMID 30907360
Japanese Journal
- 不顕性溶血によりHbA1cが偽性低値を示した有口赤血球症を合併した2型糖尿病の1例
Related Links
- Normocytic anemia and normocytic normochromic anemia. Causes, signs and symptoms, diagnosis, prognosis, and tests. The best and most important treatment is to keep the underlying condition under control.
- Normocytic anemia is caused due to age and presence of another medical condition in the body. Learn more about the symptoms, treatment and tests for diagnosing normocytic anemia.--> Medical Health Tests Diseases and ...
- Blood disease - Blood disease - Normocytic normochromic anemias: Forms of anemia in which the average size and hemoglobin content of the red blood cells are within normal limits are called normocytic normochromic ...
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- 英
- normocytic anemia
- ラ
- anaemia normocytica
- 関
- 正球性正色素性貧血