normoblasts

正赤芽球

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/10 17:17:08」(JST)

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An erythroblast is a type of red blood cell which still retains a cell nucleus. It is the immediate precursor of a normal erythrocyte.

Nomenclature

The term normoblast is sometimes used as a synonym for erythroblast, but at other times it is considered a subcategory. In the latter context, there are two types of erythroblasts:

• "normoblasts" - develop as expected
• "megaloblasts" - unusually large erythroblasts that can be associated with pernicious anemia and folic acid deficiency (collectively called megaloblastic anemia)

Development

There are four stages in the development of a normoblast.

HSC=Hematopoietic stem cell, Progenitor=Progenitor cell, L-blast=lymphoblast, Lymphocyte, Mo-blast=Monoblast, Monocyte, Myeloblast, Pro-M=Promyelocyte, Myelocyte, Meta-M=Metamyelocyte, Neutrophil, Eosinophil, Basophil, Pro-E=Proerythroblast, Baso-E=Basophilic erythroblast, poly-E=Polychromatic erythroblast, Ortho-E=orthochromatic erythroblast, Erythrocyte, Promegakaryocyte, megakaryocyte, Platlet

Illustration	Description	Image
	Pronormoblast
	Basophilic normoblast
	Polychromatic normoblast (also polychromatophilic)
	Orthochromatic normoblast (also orthochromatophilic)

Additional images

• Hematopoiesis

See also

• Erythropoiesis
• Hemopoiesis
• Pluripotential hemopoietic stem cell

External links

• Normoblasts at the US National Library of Medicine Medical Subject Headings (MeSH)
• BU Histology Learning System: 01804loa - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
• Histology at uiowa.edu

UpToDate Contents

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• 1. 末梢血塗抹標本の評価 evaluation of the peripheral blood smear
• 2. 貧血を有する成人患者に対するアプローチ approach to the adult patient with anemia
• 3. 赤血球産生調節 regulation of erythropoiesis
• 4. 骨髄穿刺塗抹標本の評価 evaluation of bone marrow aspirate smears
• 5. 小児における赤血球産生低下による貧血 anemia in children due to decreased red blood cell production

English Journal

• Bone marrow aspiration technique may have an impact on therapy stratification in children with acute lymphoblastic leukaemia.

• Helgestad J, Rosthoj S, Johansen P, Varming K, Ostergaard E.SourceDepartment of Paediatrics, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. jon.helgestad@rn.dk.
• Pediatric blood & cancer.Pediatr Blood Cancer.2011 Aug;57(2):224-6. doi: 10.1002/pbc.23081. Epub 2011 Feb 25.
• BACKGROUND: Morphological evaluation of early response to chemotherapy and measurement of minimal residual disease by flow cytometry or PCR are being used for evaluation of prognosis and treatment stratification in children with acute lymphoblastic leukaemia (ALL).PROCEDURE: In a series of 14 consec
• PMID 21360660

• Enhanced activation of autophagy in β-thalassemia/Hb E erythroblasts during erythropoiesis.

• Lithanatudom P, Wannatung T, Leecharoenkiat A, Svasti S, Fucharoen S, Smith DR.SourceMolecular Pathology Laboratory, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, 25/25 Phuttamonthon Sai 4, Salaya, Nakon Pathom, Thailand, 73170.
• Annals of hematology.Ann Hematol.2011 Jul;90(7):747-58. Epub 2011 Jan 8.
• Erythropoiesis in β-thalassemia patients is ineffective, primarily because of death of the erythroid progenitor cells at the polychromatic normoblast stage. While it is known that autophagy plays a critical role during erythropoiesis by removing organelles from erythroid cells during terminal diffe
• PMID 21221583

Japanese Journal

• 後縦隔に発生した骨髄脂肪腫の1例

• 田村 和貴,谷口 英樹
• 日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 24(1), 28-30, 2010-01-15
• 症例は62歳，男性．検診で胸部異常陰影を指摘され，精査のため当科紹介となった．胸部CTにて第10胸椎右側に接して3×2cm大の境界明瞭で辺縁平滑な腫瘤陰影を認めた．内部は不均一で脂肪組織と軟部組織の濃度が混在し，椎体骨の破壊像や胸水，周囲組織への浸潤は見られなかった．神経原性腫瘍を疑い胸腔鏡下に腫瘍摘出術を施行した．腫瘍は肉眼的には薄い被膜を有し柔らかく，卵円形で赤褐色を呈していた．組織学的には成 …
• NAID 10025954396

• Non-Megaloblastic Pernicious Anemia with Normoblasts Possessing Cytoplasmic Bridge

• Ito Yasushi,Mitsutani Susumu
• Internal Medicine 49(23), 2645-2646, 2010
• NAID 130000413418

Related Links

• Normoblast - Wikipedia, the free encyclopedia

The term normoblast is sometimes used as a synonym for erythroblast, but at other times it is considered a subcategory. In the latter context, there are two types of erythroblasts: "normoblasts" - develop as expected; "megaloblasts" - unusually ...

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