Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/02 06:10:35」(JST)

wiki en

An erythroblast is a type of red blood cell which still retains a cell nucleus. It is the immediate precursor of a normal erythrocyte.

Nomenclature

The term normoblast is sometimes used as a synonym for erythroblast, but at other times it is considered a subcategory. In the latter context, there are two types of erythroblasts:

"normoblasts" - develop as expected
"megaloblasts" - unusually large erythroblasts that can be associated with vitamin B12 deficiency (as in pernicious anemia) or folic acid deficiency (collectively called megaloblastic anemia)

Development

There are four stages in the development of a normoblast.

A comprehensive diagram of human hematopoiesis

Illustration	Description	Image
	Pronormoblast
	Basophilic normoblast
	Polychromatic normoblast (also polychromatophilic)
	Orthochromatic normoblast (also orthochromatophilic)

Additional images

Hematopoiesis

External links

Normoblasts at the US National Library of Medicine Medical Subject Headings (MeSH)
Histology image: 01804loa – Histology Learning System at Boston University - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
Histology at uiowa.edu

This cell biology article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 末梢血塗抹標本の評価 evaluation of the peripheral blood smear
2. 赤血球産生調節 regulation of erythropoiesis
3. 小児における赤血球産生低下による貧血 anemia in children due to decreased red blood cell production
4. Chapter 6J：エリスロポエチン chapter 6j erythropoietin
5. 妊娠中の微量な赤血球抗体の意義 significance of minor red blood cell antibodies during pregnancy

English Journal

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells.

Shin JW, Spinler KR, Swift J, Chasis JA, Mohandas N, Discher DE.SourceMolecular and Cell Biophysics Laboratory, University of Pennsylvania, Philadelphia, PA 19104.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Nov 4. [Epub ahead of print]
Hematopoietic stem and progenitor cells, as well as nucleated erythroblasts and megakaryocytes, reside preferentially in adult marrow microenvironments whereas other blood cells readily cross the endothelial barrier into the circulation. Because the nucleus is the largest organelle in blood cells, w
PMID 24191023

Blood parameters changes in cord blood of newborns of hypertensive mothers.

Bolat A, Gursel O, Kurekci E, Atay A, Ozcan O.SourceDepartment of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
European journal of pediatrics.Eur J Pediatr.2013 Nov;172(11):1501-9. doi: 10.1007/s00431-013-2072-x. Epub 2013 Jun 29.
The aim of this study was to investigate the changes in the peripheral blood of newborns of hypertensive mothers. The umbilical cord blood from newborns of 31 hypertensive mothers and 32 healthy mothers were examined. In all subjects, complete blood count, peripheral blood smear, reticulocyte count,
PMID 23812509

Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis.

Satchwell TJ, Pellegrin S, Bianchi P, Hawley BR, Gampel A, Mordue KE, Budnik A, Fermo E, Barcellini W, Stephens DJ, van den Akker E, Toye AM.Sourceash.m.toye@bristol.ac.uk.
Haematologica.Haematologica.2013 Nov;98(11):1788-96. doi: 10.3324/haematol.2013.085522. Epub 2013 Aug 9.
Congenital dyserythropoietic anemia type II is an autosomally recessive form of hereditary anemia caused by SEC23B gene mutations. Patients exhibit characteristic phenotypes including multinucleate erythroblasts, erythrocytes with hypoglycosylated membrane proteins and an apparent double plasma memb
PMID 23935019

Japanese Journal

Expression of α-hemoglobin stabilizing protein and cellular prion protein in a subclone of murine erythroleukemia cell line MEL

Otsuka Yayoi,Ito Daisuke,Katsuoka Kayoko,Arashiki Nobuto,Komatsu Tomohiko,Inaba Mutsumi
Japanese Journal of Veterinary Research 56(2), 75-84, 2008-08-00
… Moreover, MELhipod8 cells exhibit greater effective erythroid differentiation with a population of hemoglobinized normoblast-like cells than that observed for the parental MEL cells. …
NAID 120000947262

Ineffective erythropoiesis in β-thalassemia major is due to apoptosis at the polychromatophilic normoblast stage

MATHIAS LA
Exp Hematol. 28, 1343-1353, 2000
NAID 30002541186

Quantitative Studies on the Effects of Radiophosphorus (P-32) on Bone Marrow of Swiss Albino Mice during Postnatal Development

KUMAR ASHOK,SRIVASTAVA P.N.
Journal of Radiation Research 18(4), 280-292, 1977-11-00
… Animals were autopsied at weekly intervals upto six weeks and quantitative study of pronormoblast, normoblast, granulocyte and lymphocyte counts have been made. …
NAID 110002325717