norfluoxetine

Seproxetine
Systematic (IUPAC) name
	(S)-3-Phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
Clinical data
Routes of; administration	Oral
Legal status
Legal status	Uncontrolled;
Pharmacokinetic data
Biological half-life	4-16 days
Identifiers
CAS Number	126924-38-7
ATC code	none
PubChem	CID 4541
IUPHAR/BPS	208
DrugBank	DB06731
ChemSpider	4382
UNII	25CO3X0R31
Chemical data
Formula	C16H16F3NO
Molar mass	295.30 g/mol

ノルフルオキセチン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/16 08:15:11」(JST)

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Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI). It is the most important active metabolite of the widely used antidepressant fluoxetine, but little is known about its pharmacological actions. Seproxetine was being investigated by Eli Lilly and Company as an antidepressant; however, a cardiac side effect was noted and development was discontinued.

References

^[1]

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

^ DrugBank, ed. (2013-09-16). "Seproxetine". DrugBank.

UpToDate Contents

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1. 選択的セロトニン再取り込み阻害剤：薬理学、投与方法、および副作用 selective serotonin reuptake inhibitors pharmacology administration and side effects
2. 成人における抗うつ薬の中止 discontinuing antidepressant medications in adults
3. 乳児への授乳による抗うつ薬およびベンゾジアゼピン曝露の安全性 safety of infant exposure to antidepressants and benzodiazepines through breastfeeding
4. セロトニン症候群（serotonin toxicity） serotonin syndrome serotonin toxicity
5. 選択的セロトニン再取り込み阻害剤中毒 selective serotonin reuptake inhibitor poisoning

English Journal

New Framework To Diagnose the Direct Disposal of Prescribed Drugs in Wastewater - A Case Study of the Antidepressant Fluoxetine.

Petrie B1, Youdan J2, Barden R2, Kasprzyk-Hordern B1.
Environmental science & technology.Environ Sci Technol.2016 Apr 5;50(7):3781-9. doi: 10.1021/acs.est.6b00291. Epub 2016 Mar 24.
Intentional or accidental release (direct disposal) of high loads of unused pharmaceuticals into wastewater can go unnoticed. Here, direct disposal of a pharmaceutical drug via the sewer network was identified for the first time using wastewater analysis. An irregularly high load of the antidepressa
PMID 26974167

Evaluation of interleukin-6 and serotonin as biomarkers to predict response to fluoxetine.

Manoharan A1, Rajkumar RP2, Shewade DG1, Sundaram R1, Muthuramalingam A2, Paul A3.
Human psychopharmacology.Hum Psychopharmacol.2016 Mar 27. doi: 10.1002/hup.2525. [Epub ahead of print]
OBJECTIVE: Only 30% of major depressive disorder (MDD) patients achieve complete remission with a serotonergic antidepressant (selective serotonin reuptake inhibitor). We investigated the potential of serotonin (5-HT) and interleukin-6 (IL-6) to serve as functional biomarkers of fluoxetine response.
PMID 27018372

Development of a modified acetonitrile-based extraction procedure followed by ultra-high performance liquid chromatography-tandem mass spectrometry for the analysis of psychiatric drugs in sediments.

Santos LH1, Ramalhosa MJ2, Ferreira M3, Delerue-Matos C2.
Journal of chromatography. A.J Chromatogr A.2016 Mar 11;1437:37-48. doi: 10.1016/j.chroma.2016.01.079. Epub 2016 Feb 4.
An analytical method based on a modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) extraction procedure followed by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed for the analysis of psychiatric drugs in sediments. An optimized appro
PMID 26879455

Japanese Journal

A validated enantioselective assay for the simultaneous quantitation of (R)-, (S)-fluoxetine and (R)-, (S)-norfluoxetine in ovine plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS)

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 879(5), 349-358, 2011-02-15
NAID 10029516871

Determination of fluoxetine, norfluoxetine and their enantiomers in rat plasma and brain samples by liquid chromatography with fluorescence detection

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 852(1), 519-528, 2007-06-01
NAID 10025802768

Solid-phase microextraction-liquid chromatography (SPME-LC) determination of fluoxetine and norfluoxetine in plasma using a heated liquid flow through interface

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 847(2), 217-223, 2007-03-01
NAID 10025792423

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