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1. 妊娠性絨毛性疾患：病理 gestational trophoblastic disease pathology
2. 松果体部腫瘍 pineal gland masses
3. 虫垂粘液嚢胞 appendiceal mucoceles
4. 脊髄腫瘍 spinal cord tumors
5. 膵外分泌腫瘍の病理 pathology of exocrine pancreatic neoplasms

English Journal

Loss of CDC14B Expression in Clear Cell Renal Cell Carcinoma: Meta-Analysis of Microarray Data Sets.

Kim Y1, Choi JW, Lee JH, Kim YS.Author information 1Dept of Pathology, Korea University Ansan Hospital, 516, Gojan-1 Dong, Danwon-Gu, Ansan-Si, Gyeonggi-Do, 425-707, Republic of Korea; e-mail: apysk@korea.ac.kr.AbstractObjectives: To discover significant differentially expressed genes (DEGs) in clear cell renal cell carcinoma (ccRCC) that might be unidentified by single microarray analysis. Methods: The effect sizes of five ccRCC microarray data sets were combined using a random-effects model. The most downregulated gene was validated in paired 80 ccRCC tissues by immunohistochemistry. Results: CDC14B was the most downregulated gene among 1,761 DEGs. CDC14B was strongly expressed in the apical proximal tubules in the nonneoplastic tissues, while it was completely absent in 10 (12.5%) of 80 or downregulated in 70 (87.5%) of 80 ccRCC cases. The complete loss of CDC14B correlated with high T stage (P = .038), advanced TNM stage (P = .027), tumor recurrence (P = .038), and shorter recurrence-free survival (P = .046) compared with the partial loss of CDC14B. Conclusions: Microarray meta-analysis is a useful tool for pathologists. CDC14B expression is downregulated in ccRCC, suggesting its role in renal carcinogenesis.
American journal of clinical pathology.Am J Clin Pathol.2014 Apr;141(4):551-8. doi: 10.1309/AJCP4PE4JPSRGBQS.
Objectives: To discover significant differentially expressed genes (DEGs) in clear cell renal cell carcinoma (ccRCC) that might be unidentified by single microarray analysis. Methods: The effect sizes of five ccRCC microarray data sets were combined using a random-effects model. The most downregulat
PMID 24619757

The spectrum of cervical glandular neoplasia and issues in differential diagnosis.

Loureiro J1, Oliva E.Author information 1From the Department of Pathology, Instituto Português de Oncologia, Porto, Portugal (Dr Loureiro); and the Department of Pathology, Massachusetts General Hospital, Boston (Dr Oliva).AbstractContext.-Premalignant and malignant glandular lesions of the cervix are known to often cause diagnostic problems with a variety of benign (more common) as well as other malignant mimics, the latter setting often being represented by secondary involvement by endometrioid endometrial carcinoma especially in small samplings. Objective.-To highlight key histologic features and immunohistochemical markers that may be helpful in the distinction of in situ endocervical carcinoma from benign glandular proliferations, and those that separate different subtypes of invasive endocervical carcinoma, as well as invasive carcinoma from other carcinomas secondarily involving the cervix and nonneoplastic proliferations of the cervix. Conclusions.-Clinical and morphologic features as well as immunohistochemistry results should be used in conjunction in the differential diagnosis of glandular proliferations of the cervix, as correct interpretation has major clinical consequences for the patient in most instances (especially benign versus malignant). Immunohistochemical markers should be used as part of a panel of antibodies, as exceptions may occur to the usual pattern of staining, and if used singly, they may mislead the pathologist to establish a wrong diagnosis.
Archives of pathology & laboratory medicine.Arch Pathol Lab Med.2014 Apr;138(4):453-83. doi: 10.5858/arpa.2012-0493-RA.
Context.-Premalignant and malignant glandular lesions of the cervix are known to often cause diagnostic problems with a variety of benign (more common) as well as other malignant mimics, the latter setting often being represented by secondary involvement by endometrioid endometrial carcinoma especia
PMID 24678677

Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice.

Surh I1, Rao DB2, Cesta MF3, Hébert CD4, Mann JF4, Cunny H3, Kissling GE3, Malarkey D3, Chhabra RS3.Author information 1National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address: surhi@niehs.nih.gov.2National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; Integrated Laboratory Systems, Inc., Research Triangle Park, NC 27709, USA.3National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.4Southern Research Institute, Birmingham, AL 35255, USA.AbstractTrimethylolpropane triacrylate (TMPTA) is a multifunctional monomer with industrial applications. To determine the carcinogenic potential, male and female F344/N rats and B6C3F1/N mice were administered TMPTA (0, 0.3, 1.0, or 3.0mg/kg) in acetone dermally for 2years. There were no differences in the body weights and survival in the treated animals compared to controls. Nonneoplastic skin lesions at the site of application included epidermal hyperplasia and hyperkeratosis in both rats and mice. There were no incidences of tumors at the site of application in rats and mice. Rare malignant liver neoplasms were observed in female mice that included hepatoblastoma in the 0.3 and 3.0mg/kg groups, and hepatocholangiocarcinoma in the 1.0 and 3.0mg/kg groups. The incidences of uterine stromal polyp and stromal polyp or stromal sarcoma (combined) in female mice occurred with positive trends and the incidences were significantly increased in the 3.0mg/kg group. A marginal increase in the incidences of malignant mesothelioma in male rats may have been related to TMPTA treatment. In conclusion, our studies show that TMPTA is a dermal irritant in both rats and mice of either sex. Increased incidences of tumor formation were observed in female mice and male rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2014 Apr;66:254-61. doi: 10.1016/j.fct.2014.01.048. Epub 2014 Feb 3.
Trimethylolpropane triacrylate (TMPTA) is a multifunctional monomer with industrial applications. To determine the carcinogenic potential, male and female F344/N rats and B6C3F1/N mice were administered TMPTA (0, 0.3, 1.0, or 3.0mg/kg) in acetone dermally for 2years. There were no differences in the
PMID 24503412