nondepolarizing blocking drugs

日

関

WordNet

1. use recreational drugs (同)do drugs
2. administer a drug to; "They drugged the kidnapped tourist" (同)dose
3. a substance that is used as a medicine or narcotic
4. the act of obstructing or deflecting someones movements (同)block

PrepTutorEJDIC

1. 『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる

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• 1. 麻酔導入時の神経筋遮断薬の使用clinical use of neuromuscular blocking agents in anesthesia [show details]
  … administration of succinylcholine on subsequent administration of a nondepolarizing neuromuscular block depends on the drug used. Studies have reported that administration of succinylcholine prior to a nondepolarizing …
• 2. 手術室外で成人に迅速導入気管挿管を行う際に用いる神経筋遮断薬（NMBA）neuromuscular blocking agents nmbas for rapid sequence intubation in adults outside of the operating room [show details]
  … sedative and a NMBA in the emergency department (ED) . NMBAs are integral to the performance of RSI. Multiple randomized trials and observational studies demonstrate that the use of NMBAs improves success …
• 3. 全身麻酔：維持general anesthesia maintenance [show details]
  … before emergence from general anesthesia. Agent-specific uses, dosing, advantages, disadvantages, drug-drug interactions, and pharmacokinetics for opioids employed during maintenance of general anesthesia … a neuromuscular blocking agent (NMBA) is employed to provide muscle relaxation or complete paralysis. Use of an NMBA may also reduce total…
• 4. 全身麻酔：導入general anesthesia induction [show details]
  … incidence of drug-related side effects, we typically administer multiple agents to accomplish anesthetic induction, including one or more adjuvant agents, and a neuromuscular blocking agent (NMBA) if endotracheal …
• 5. 危篤状態の患者への神経筋遮断薬の使用clinical use of neuromuscular blocking agents in critically ill patients [show details]
  … of distribution of NMBAs . Decreased cardiac output may also prolong drug delivery and slow the onset of action of NMBAs. Increased age may contribute to a reduction in the rate of drug elimination via decreases …

English Journal

• PMID 30137795

• Anesthesiologists' Overconfidence in Their Perceived Knowledge of Neuromuscular Monitoring and Its Relevance to All Aspects of Medical Practice: An International Survey.

• Naguib M, Brull SJ, Hunter JM, Kopman AF, Fülesdi B, Johnson KB, Arkes HR.
• Anesthesia and analgesia. 2019 Jun;128(6)1118-1126.
• In patients who receive a nondepolarizing neuromuscular blocking drug (NMBD) during anesthesia, undetected postoperative residual neuromuscular block is a common occurrence that carries a risk of potentially serious adverse events, particularly postoperative pulmonary complications. There is abundan
• PMID 31094776

• Influence of Reversal of a Partial Neuromuscular Block on the Ventilatory Response to Hypoxia: A Randomized Controlled Trial in Healthy Volunteers.

• Broens SJL, Boon M, Martini CH, Niesters M, van Velzen M, Aarts LPHJ, Dahan A.
• Anesthesiology. 2019 Apr;().
• The ventilatory response to hypoxia is a critical reflex that is impaired by neuromuscular blocking drugs. However, the degree to which this reflex is restored after reversal of blockade is unknown. Despite full reversal of neuromuscular blockade at the thumb using different drug classes, this hypox
• PMID 31045894

Japanese Journal

• 筋弛緩作用が一定になるよう持続静注した後に，筋弛緩薬投与を中止した時の作用回復のシミュレーション　　パンクロニウム，ベクロニウム，ロクロニウムの比較:パンクロニウム,ベクロニウム,ロクロニウムの比較

• 日臨麻会誌 19(10), 601-608, 1999
• NAID 130003428287

• Difference of train-of-four fade induced by nondepolarizing neuromuscular blocking drugs: a theoretical consideration on the underlying mechanisms

• Journal of anesthesia 9(4), 333-337, 1995-11-20
• NAID 10009321974

• Kinetic Analysis of Neuromuscular Blockade. I. Relationship between Twitch Depression and Stimulation Frequency after d-Tubocurarine Administration.

• Ｂｉｏｌ．　Ｐｈａｒｍ．　Ｂｕｌｌ． 17(8), 1083-1088, 1994
• NAID 110003640711

Related Links

• Neuromuscular Blocking Drugs - Depolarizing & Nondepolarizing

http://usmlefasttrack.com/?p=1903 Neuromuscular, Blocking, Drugs, Depolarizing, Nondepolarizing, Succinylcholine, nictonic receptor, phase 1, phase 2, block, reveral of blockade, prolonged depolarization ...

• List of Neuromuscular blocking agents - Drugs.com

Neuromuscular blocking agents are potent muscle relaxants typically only used during surgery to prevent muscle movement. They are structurally related to acetylcholine (the main neurotransmitter in the body) and they cause muscle ...

• Neuromuscular Blocking Agents (Systemic) - Drugs.com ...

*Hydrolyzed rapidly to succinylmonocholine (a weak nondepolarizing neuromuscular blocking agent that is one-twentieth as potent as succinylcholine), then more slowly to succinic acid and choline. † Metabolized by ester hydrolysis ...

Related Pictures

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★リンクテーブル★

リンク元	「非脱分極性筋弛緩薬」
関連記事	「nondepolarizing」「drug」

「非脱分極性筋弛緩薬」

　　[★]

英

nondepolarizing muscle relaxant non-depolarizing muscle relaxant

同

競合的神経筋遮断薬 competitive neuromuscular blocker、競合的筋弛緩薬 competitive muscle relaxant、非脱分極性神経筋遮断薬 non-depolarizing neuromuscular blocker、非脱分極性遮断薬 nondepolarizing blocking drugs、クラーレ様作用薬 curarimimetic、クラーレ様物質

関

脱分極性筋弛緩薬、筋弛緩薬、Train of four monitor、脱分極性遮断薬、神経筋接合部遮断薬

[show details]

非脱分極性遮断薬 : 18 件
非脱分極性筋弛緩薬 : 約 29,600 件
非脱分極性神経筋遮断薬 : 22 件
競合的遮断薬 : 約 48 件
競合的筋弛緩薬 : 約 26 件
競合的神経筋遮断薬 : 16 件

• ニコチン性アセチルコリン受容体にアセチルコリンと競合的に結合することで、アセチルコリンの受容体結合を阻害
• 脱分極させることなく、アセチルコリンと競合してアセチルコリン結合部位への結合を妨げる。

• アトラクリウム

• d-ツボクラリン：ヒスタミン遊離作用を有する。 (=d-tubocurarine(クラーレ))
• パンクロニウム：
• ベクロニウム：
• ロクロニウム：スガマデックスで拮抗される

• 重症筋無力症の場合、(競合してAch受容体を奪うため)少量の非脱分極性筋弛緩薬でも筋弛緩が出現 (SPC.169)

拮抗薬

• 一般的には、コリンエステラーゼ阻害薬であるネオスチグミンやエドロフォニウムを用いる。
• ロクロニウムに対してはスガマデックスを使用することができる。

「nondepolarizing」

　　[★]

• 非脱分極性の

関

antidepolarizing

「drug」

　　[★]

同

drugs