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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/10 12:56:18」(JST)
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Nitromersol
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Names |
IUPAC name
5-Methyl-2-nitro-7-oxa-8-mercurabicyclo[4.2.0]octa-1(6),2,4-triene
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Other names
Metaphen; 6-Methyl-3-nitrobenzoxamercurete; 4-Nitro-5-hydroxymercuriorthocresol
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Identifiers |
CAS Registry Number
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133-58-4 Y |
ChemSpider |
16739372 |
InChI
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InChI=1S/C7H6NO3.Hg/c1-5-2-3-6(8(10)11)4-7(5)9;/h2-3,9H,1H3;/q;+1/p-1
Key: UEHLXXJAWYWUGI-UHFFFAOYSA-M
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InChI=1/C7H6NO3.Hg/c1-5-2-3-6(8(10)11)4-7(5)9;/h2-3,9H,1H3;/q;+1/p-1/rC7H5HgNO3/c1-4-2-3-5(9(10)11)6-7(4)12-8-6/h2-3H,1H3
Key: UEHLXXJAWYWUGI-ITKDQSLKAT
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Jmol-3D images |
Image |
PubChem |
16682935 |
SMILES
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Cc1ccc(c2[Hg]Oc12)[N+]([O-])=O
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UNII |
RU6242GP15 |
Properties |
Chemical formula
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C7H5HgNO3 |
Molar mass |
351.71 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references |
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Nitromersol (metaphen) is a mercury-containing organic compound that is primarily used as an antiseptic and disinfectant. It has no odor or taste and is stored as a brown-yellow granules or powder. Nitromersol does not irritate the skin or mucous membranes and has no impact on rubber or metallic instruments, including surgical and dental tools.[1]
This compound is a confirmed animal carcinogen. It can emit toxic fumes of NOx and mercury when destroyed by heat.[2] In 1998, use of nitromersol (and other mercury-containing products) as OTC first-aid antiseptics and products for diaper rash and vaginal contraceptives was disallowed by the FDA.[3] Nitromersol can cause hypersensitivity reactions, but it is still in use as a preservative for vaccines and antitoxins.[4]
References
- ^ Hospital formulary and compendium of useful information. Berkeley, California: University of California Press. 1941. p. 113. Retrieved 2011-04-08.
- ^ Lewis, Richard J. (2008). Hazardous chemicals desk reference. Wiley-Interscience. p. 1018. ISBN 0-470-18024-2. Retrieved 2011-04-08.
- ^ Remington: the science and practice of pharmacy. Medicine Series 1 (21st ed.). Lippincott Williams & Wilkins. 2005. p. 369. ISBN 0-7817-4673-6.
- ^ Trevor, Anthony J.; Katzung, Bertram G.; Masters, Susan B. (2007). Katzung & Trevor's pharmacology: examination & board review. Lange Basic Science (8th ed.). McGraw-Hill Professional. p. 420. ISBN 0-07-148869-3.
Mercury compounds
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Mercury(I) |
- HgH
- Hg2H2
- Hg2Br2
- Hg2Cl2
- Hg2F2
- Hg2I2
- Hg2(NO3)2
- Hg2O
- Hg2CO3
- Hg2SO4
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Mercury(II) |
- HgH2
- HgNH2Cl
- HgSe
- HgS
- HgTe
- Hg(O2CCH3)2
- HgBr2
- HgCl2
- Hg(CN)2
- HgF2
- Hg(OH)2
- HgI2
- Hg(NO3)2
- HgO
- HgSO4
- Hg(SCN)2
- Hg(CNO)2
- Hg3N2
- Hg(Si(CH3)3)2
- K2HgI4
Organomercury
compounds
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- Hg(CH3)2
- Hg(C2H5)2
- Hg(C6H5)2
- HgC6H5CH3CO2
- HgC6H5OB(OH)2
- HgClC6H4CO2H
- HgOHCH2CHOCH3CH2(NHCO)2C2H4CO2H
- HgOHCH2CHOCH3CH2NHCOC6H4OCH2CO2H
- Na2HgOHC6HOBrC6H2OBrOCHC6H4CO2
- HgOC6H2CH3NO2
- NaHgC2H5SC6H4CO2
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Mercury(IV) |
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Amalgams |
- Na(Hg)
- Al(Hg)
- K(Hg)
- Au(Hg)
- Tl(Hg)
- Sn(Hg)
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Mercury cations |
- Hg2+
- Hg4+
- Hg22+
- Hg32+
- Hg42+
- Hg34+
- HgCH3+
- HgC2H5+
- HgC6H5+
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English Journal
- Toxicity of organomercury compounds: bioassay results as a basis for risk assessment.
- Hempel M1, Chau YK, Dutka BJ, McInnis R, Kwan KK, Liu D.
- The Analyst.Analyst.1995 Mar;120(3):721-4.
- A former mercury plant, where mercury salts and organomercurials for pesticide use were produced, caused soil contamination in high concentrations. Typical organomercurial products included ethylmercury, phenylmercury, methoxyethylmercury and ethoxyethylmercury compounds. Risk assessment of these si
- PMID 7741224
- Determination of organic mercury species in soils by high-performance liquid chromatography with ultraviolet detection.
- Hempel M1, Hintelmann H, Wilken RD.
- The Analyst.Analyst.1992 Mar;117(3):669-72.
- Reversed-phase high-performance liquid chromatography with ultraviolet detection was optimized for the simultaneous separation and quantification of nine organic mercury compounds: methyl-, ethyl-, phenyl-, methoxyethyl-, ethoxyethyl-, benzoic and tolylmercury, mersalylic acid and nitromersol. The n
- PMID 1580417
- Antibacterial action of commercial nitromersol preparations.
- CROMWELL HW.
- Journal of the American Medical Association.J Am Med Assoc.1949 May 28;140(4):401-3.
- PMID 18128621
Related Links
- Nitromersol (metaphen) is a mercury-containing organic compound containing that is primarily used as an antiseptic and disinfectant. It has no odor or taste and is stored as a brown-yellow granules or powder. Nitromersol does not irritate the ...
- Synthetic mercury -containing organic compound used as an antiseptic for the skin and mucous membranes and as a disinfectant for sterilizing surgical instruments. It is related to merbromin (Mercurochrome)...
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