nitrogen mustards

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/24 05:16:28」(JST)

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  • Synthesis, structure-activity relationship and biological evaluation of novel nitrogen mustard sophoridinic acid derivatives as potential anticancer agents.
  • Li DD1, Dai LL2, Zhang N2, Tao ZW3.
  • Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Oct 1;25(19):4092-6. doi: 10.1016/j.bmcl.2015.08.035. Epub 2015 Aug 18.
  • A series of novel nitrogen mustard sophoridinic acid derivatives were designed, synthesized and evaluated for their cytotoxicity. Of the newly synthesized compounds, compound 6 exhibited a potent effect against hepatocellular carcinoma in vitro and in vivo. SAR analysis indicated that introduction o
  • PMID 26299348
  • Treatment of melanoma with a serotype 5/3 chimeric oncolytic adenovirus coding for GM-CSF: Results in vitro, in rodents and in humans.
  • Bramante S1, Kaufmann JK2, Veckman V3, Liikanen I1, Nettelbeck DM2, Hemminki O1, Vassilev L4, Cerullo V1,5, Oksanen M1, Heiskanen R4, Joensuu T6, Kanerva A1,7, Pesonen S1, Matikainen S3, Vähä-Koskela M1, Koski A1, Hemminki A1,8.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2015 Oct 1;137(7):1775-83. doi: 10.1002/ijc.29536. Epub 2015 Apr 11.
  • Metastatic melanoma is refractory to irradiation and chemotherapy, but amenable to immunological approaches such as immune-checkpoint-inhibiting antibodies or adoptive cell therapies. Oncolytic virus replication is an immunogenic phenomenon, and viruses can be armed with immunostimulatory molecules.
  • PMID 25821063
  • High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites.
  • Naito T1, Baba T2, Takeda K3, Sasaki S2, Nakamoto Y4, Mukaida N5.
  • Cancer letters.Cancer Lett.2015 Sep 28;366(1):93-9. doi: 10.1016/j.canlet.2015.06.009. Epub 2015 Jun 24.
  • Cancer chemotherapy regimens, particularly those employing high-dose cytotoxic drugs such as cyclophosphamide (CTX), have been considered to be immune suppressive. However, we observed that a single administration of high-dose CTX abolished tumors arising from subcutaneous injection of a mouse hepat
  • PMID 26116901


  • Rapid and sensitive ultra-high-pressure liquid chromatography-tandem mass spectrometry analysis of the novel anticancer agent PR-104 and its major metabolites in human plasma : Application to a pharmacokinetic study
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 877(27), 3181-3186, 2009-10-01
  • NAID 10028025483
  • Development of Spray Deposition/MALDI-TOFMS and Its Application to the Rapid Screening of Hydrolysis Products Derived from Nitrogen Mustards
  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 25(7), 845-849, 2009-07-10
  • NAID 10025213307
  • Development of Spray Deposition/MALDI-TOFMS and Its Application to the Rapid Screening of Hydrolysis Products Derived from Nitrogen Mustards


The Chinese anti-tumor drugs can be divided into nine categories: Alkylation Agents, such as nitrogen mustards, ethylene-imines, methanesulfonates, polyatomic alcohols and SarCNU; Anti-metabolite drugs, such as pyrimidine ...
Because it is heavier than air, nitrogen mustard vapor will settle in low-lying areas. How nitrogen mustards work Adverse health effects caused by nitrogen mustards depend on the amount of nitrogen mustard to which ...






nitrogen mustard
窒素マスタード、窒素イペリット nitrogen yperiteメクロルエタミン mechlorethamine



  • n.
Brassica junceaIndian mustard

WordNet   license wordnet

「any of several cruciferous plants of the genus Brassica」

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「leaves eaten as cooked greens」
mustard greens, leaf mustard, Indian mustard

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「pungent powder or paste prepared from ground mustard seeds」
table mustard

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「カラシ(アブラナ属の植物の総称) / マスタード,粉(練り)からし」



  • n.

WordNet   license wordnet

「a common nonmetallic element that is normally a colorless odorless tasteless inert diatomic gas; constitutes 78 percent of the atmosphere by volume; a constituent of all living tissues」
N, atomic number 7

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