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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/04/04 12:27:06」(JST)
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Nitrofural
|
Systematic (IUPAC) name |
5-nitro-2-furaldehyde semicarbazone |
Clinical data |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Pregnancy cat. |
C (US) |
Legal status |
? |
Identifiers |
CAS number |
59-87-0 Y |
ATC code |
B05CA03 D08AF01 D09AA03 (dressing) P01CC02 S01AX04 S02AA02 QG01AX90 QP51AC02 |
PubChem |
CID 5447130 |
DrugBank |
DB00336 |
ChemSpider |
4566720 Y |
UNII |
X8XI70B5Z6 Y |
KEGG |
C08042 N |
ChEMBL |
CHEMBL869 Y |
Chemical data |
Formula |
C6H6N4O4 |
Mol. mass |
198.14 g/mol |
SMILES
- O=[N+]([O-])c1oc(/C=N/NC(=O)N)cc1
|
InChI
-
InChI=1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+ Y
Key:IAIWVQXQOWNYOU-FPYGCLRLSA-N Y
|
N (what is this?) (verify) |
Nitrofural (INN, trade name Furacin) is a bactericidal compound used as an antibiotic most commonly in the form of ointments. Its use in medicine has become less frequent as safer and more effective products have become available[citation needed], and it has been discontinued in the US.[1] The substance is pale yellow and crystalline.
Other names include nitrofurazone and furacilin.
Synthesis
Synthesis:[2]
References
- ^ Drugs.com: Nitrofurazone (Topical route)
- ^ Stillman, W. B.; Scott, A. B.; 1947, U.S. Patent 241,664.
Antiparasitics – antiprotozoal agents – Chromalveolate antiparasitics (P01)
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Alveo-
late |
Apicom-
plexa |
Conoidasida/
(Coccidiostats) |
Cryptosporidiosis |
|
|
Isosporiasis |
- trimethoprim/sulfamethoxazole#
|
|
Toxoplasmosis |
- pyrimethamine
- sulfadiazine
|
|
|
Aconoidasida |
Malaria |
Individual
agents |
Hemozoin
inhibitors |
aminoquinolines |
- (4-): amodiaquine#
- chloroquine#
- (8-): primaquine#
- pamaquine
|
|
4-methanolquinolines |
- mefloquine#
- quinine#
- quinidine
|
|
Other |
|
|
|
Antifolates |
DHFR inhibitors
(antifols) |
- proguanil#
- chlorproguanil
|
|
Sulfonamides |
- sulfadoxine
- sulfamethoxypyrazine
|
|
Coformulation |
- sulfadoxine/pyrimethamine (SP)#
|
|
|
Sesquiterpene
lactones |
- artemether#
- artesunate#
- dihydroartemisinin
- artemotil
- artemisinin
|
|
Other |
- atovaquone (with proguanil as Malarone)
- tetracycline
- doxycycline#
- clindamycin
- pyronaridine
- piperaquine
|
|
|
Combi-
nations |
Fixed-dose (coformulated) ACTs |
- artemether/lumefantrine#
- artesunate/amodiaquine (ASAQ)
- artesunate/mefloquine (ASMQ)
- dihydroartemisinin/piperaquine
- artesunate/pyronaridine
|
|
Other combinations
(not co-formulated) |
- artesunate/SP
- artesunate/mefloquine
- quinine/tetracycline
- quinine/doxycycline
- quinine/clindamycin
|
|
|
|
Babesiosis |
|
|
|
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Cilio-
phora |
- Balantidiasis: Tetracycline
|
|
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Hetero-
kont |
- Blastocystosis: Metronidazole
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
Otologicals (S02)
|
|
Anti-infectives |
- Acetic acid
- Aluminium acetotartrate
- Boric acid
- Chloramphenicol
- Chlorhexidine
- Ciprofloxacin
- Clioquinol
- Gentamicin
- Hydrogen peroxide
- Miconazole
- Neomycin
- Nitrofurazone
- Ofloxacin
- Polymyxin B
- Rifamycin
- Tetracycline
|
|
Corticosteroids |
- Betamethasone
- Dexamethasone
- Fluocinolone acetonide
- Hydrocortisone
- Prednisolone
|
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Analgesics and anesthetics |
- Lidocaine
- Cocaine
- Phenazone
|
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English Journal
- Antinociceptive and wound healing activities of Croton adamantinus Müll. Arg. essential oil.
- Ximenes RM, de Morais Nogueira L, Cassundé NM, Jorge RJ, Dos Santos SM, Magalhães LP, Silva MR, de Barros Viana GS, Araújo RM, de Sena KX, de Albuquerque JF, Martins RD.SourceDepartment of Physiology and Pharmacology, Federal University of Ceará, Rua Coronel Nunes de Melo 1315, Fortaleza, CE, 60.430-270, Brazil, ximenesrm@gmail.com.
- Journal of natural medicines.J Nat Med.2013 Oct;67(4):758-64. doi: 10.1007/s11418-012-0740-1. Epub 2013 Jan 22.
- Leaves of Croton adamantinus have been used to treat inflammation and skin wounds in the semi-arid area of the Northeast of Brazil. In order to evaluate if the essential oil (EO) was responsible for the claimed activities; antinociceptive, wound healing and antimicrobial tests were carried out. Twen
- PMID 23339025
- Histopathological and clinical evaluation of Kombucha tea and Nitrofurazone on cutaneous full-thickness wounds healing in rats: an experimental study.
- Barati F, Javanbakht J, Adib-Hashemi F, Hosseini E, Safaeie R, Rajabian M, Razmjoo M, Sedaghat R, Aghamohammad Hassan M.AbstractBACKGROUND: Kombucha, a fermented tea (KT) is claimed to possess many beneficial properties. The aim of this study was to evaluate clinical and histopathological alterations of Kombucha tea and Nitrofurazone on cutaneous full-thickness wounds healing in rat.
- Diagnostic pathology.Diagn Pathol.2013 Jul 17;8(1):120. [Epub ahead of print]
- BACKGROUND: Kombucha, a fermented tea (KT) is claimed to possess many beneficial properties. The aim of this study was to evaluate clinical and histopathological alterations of Kombucha tea and Nitrofurazone on cutaneous full-thickness wounds healing in rat.METHODS: In present study 24 Wister -albin
- PMID 23866960
- Pharmacokinetics of hydroxymethylnitrofurazone and its parent drug nitrofurazone in rabbits.
- Nogueira Filho MA, Padilha EC, Campos ML, Pontes Machado DV, Davanço MG, Pestana KC, Chin CM, Peccinini RG.SourceUniversidade Estadual Paulista "Júlio de Mesquita Filho" - UNESP, School of Pharmaceutical Sciences, Rodovia Araraquara-Jaú Km. 01 s/n - Campus universitário, Araraquara, São Paulo. nogueira-m@hotmail.com.
- Drug metabolism letters.Drug Metab Lett.2013 Jul 15. [Epub ahead of print]
- The prodrug hydroximethylnitrofurazone (NFOH) presents antichagasic activity with greatly reduced toxicity compared to its drug matrix nitrofurazone (NF). Besides these new characteristics, the prodrug was more active against the parasite T. cruzi amastigotes. These advantages make the prodrug a pos
- PMID 23957951
Japanese Journal
- 上坂 竹茂,脇坂 悌治,梶川 欽一郎,福田 正則
- 結核 28(2), 1953
- … Daily injections of 5-nitrofural doxim and guanofuracin were made on tuberculous animals, which were subsequently autopsied at the end of a definite period in order to know their respective effect on experimental tuberculosis. … Clinical effect of 5-nitrofural doxim was also investigated on the patients of pyothorax. …
- NAID 130001411667
Related Links
- The most updated news about prescription drugs, over the counter drugs, natural medications, side effects, drug interactions and warnings. ... Nitrofural is used in the treatment of: Burns Clostridium Infections Escherichia coli ...
- Nitrofurazone is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg) Find all the information about Nitrofurazone (Nitrofural) for cell signaling research.
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