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| Systematic (IUPAC) name | |
|---|---|
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[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate
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| Clinical data | |
| Trade names | Alinia, Nizonide, and others |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a603017 |
| Licence data | US FDA:link |
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| Legal status |
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| Routes of administration |
Oral |
| Pharmacokinetic data | |
| Protein binding | Nitazoxanide: ? Tizoxanide: over 99%[1][2] |
| Metabolism | Rapidly hydrolyzed to tizoxanide[1] |
| Metabolites | tizoxanide[1][2] tizoxanide glucuronide[1][2] |
| Biological half-life | 3.5 hours[3] |
| Excretion | Renal, biliary, and fecal[1] |
| Identifiers | |
| CAS Number | 55981-09-4 Y |
| ATC code | P01AX11 |
| PubChem | CID 41684 |
| DrugBank | DB00507 Y |
| ChemSpider | 38037 Y |
| UNII | SOA12P041N Y |
| KEGG | D02486 Y |
| ChEMBL | CHEMBL1401 Y |
| NIAID ChemDB | 057131 |
| Chemical data | |
| Formula | C12H9N3O5S |
| Molar mass | 307.283 g/mol |
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Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections.[4][5][6] It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza.[1][6] Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths;[4][7] emerging evidence suggests that it possesses efficacy in treating a number of viral infections as well.[6]
Chemically, nitazoxanide is the prototype member of the thiazolides, a class of drugs which are synthetic nitrothiazolyl-salicylamide derivatives with antiparasitic and antiviral activity.[4][6][8] Tizoxanide, an active metabolite of nitazoxanide in humans, is also an antiparasitic drug of the thiazolide class.[4][9]
Contents
- 1 Uses
- 1.1 Chronic hepatitis B
- 1.2 Chronic hepatitis C
- 1.3 Clinical trials
- 2 Contraindications
- 3 Adverse effects
- 4 Overdose
- 5 Interactions
- 6 Pharmacology
- 6.1 Pharmacodynamics
- 6.2 Pharmacokinetics
- 7 Physical and chemical properties
- 8 History
- 9 Pharmaceutical products
- 9.1 Dosage forms
- 9.2 Brand names
- 10 References
- 11 External links
Uses
Nitazoxanide is an effective first-line treatment for infection by Blastocystis species[10][11] and is indicated for the treatment of infection by Cryptosporidium parvum or Giardia lamblia in immunocompetent adults and children.[1] It is also an effective treatment option for infections caused by other protozoa and helminths (e.g., Entamoeba histolytica,[12] Hymenolepis nana,[13] Ascaris lumbricoides,[14] and Cyclospora cayetanensis[15]).[7]
As of September 2015[update], it is in phase 3 clinical trials for the treatment influenza due to its inhibitory effect on a broad range of influenza virus subtypes and efficacy against influenza viruses that are resistant to neuraminidase inhibitors like tamiflu.[6][16] Nitazoxanide is also being researched as a potential treatment for chronic hepatitis B, chronic hepatitis C, rotavirus and norovirus gastroenteritis.[6]
Chronic hepatitis B
Nitazoxanide alone has shown preliminary evidence of efficacy in the treatment of chronic hepatitis B over a one-year course of therapy.[17] Nitazoxanide 500 mg twice daily resulted in a decrease in serum HBV DNA in all of 4 HBeAg-positive patients, with undetectable HBV DNA in 2 of 4 patients, loss of HBeAg in 3 patients, and loss of HBsAg in one patient. Seven of 8 HBeAg-negative patients treated with nitazoxanide 500 mg twice daily had undetectable HBV DNA and 2 had loss of HBsAg. Additionally, nitazoxanide monotherapy in one case and nitazoxanide plus adefovir in another case resulted in undetectable HBV DNA, loss of HBeAg and loss of HBsAg.[18] These preliminary studies showed a higher rate of HBsAg loss than any currently licensed therapy for chronic hepatitis B. The similar mechanism of action of interferon and nitazoxanide suggest that stand-alone nitazoxanide therapy or nitazoxanide in concert with nucleos(t)ide analogs have the potential to increase loss of HBsAg, which is the ultimate end-point of therapy. A formal phase Ⅱ study is being planned for 2009.[19] you can see results for off label use of alinia (nitazoxanide) on medhelp hbv community, it is reported a significant drop of more than 50% hbsag quantity from baseline values on hbeag negative hbv at 1,5-2g daily dose (500 mg pills every 6-8hrs with food) already at 3–6 months therapy, especially in combination with peginterferon or entecavir.[20]
Chronic hepatitis C
Romark initially decided to focus on the possibility of treating chronic hepatitis C with nitazoxanide.[21] The drug garnered interest from the hepatology community after three phase II clinical trials involving the treatment of hepatitis C with nitazoxanide produced positive results for treatment efficacy and similar tolerability to placebo without any signs of toxicity.[21] Subsequent clinical trials are ongoing.[21][22]
A new dosage form of nitazoxanide for use in chronic hepatitic C was developed for future clinical trials.[21] The extended release tablet provides a larger dose of nitazoxanide (675 mg) than the current tablets (500 mg) and is intended to be used twice daily for 7 days.[21]
Clinical trials
| This section is outdated. Please update this article to reflect recent events or newly available information. (April 2014) |
Romark Laboratories has announced encouraging results from international Phase I and II clinical trials evaluating a controlled release version of nitazoxanide in the treatment of chronic hepatitis C virus infection. The company used 675 mg and 1,350 mg twice daily doses of controlled release nitazoxanide showed favorable safety and tolerability throughout the course of the study, with mild to moderate adverse events. Primarily GI-related adverse events were reported.
Nitazoxanide is has gone through Phase II clinical trials for the treatment of hepatitis C, in combination with peginterferon alfa-2a and ribavirin.[23][24]
A randomised double-blind placebo-controlled study published in 2006, with a group of 38 young children (Lancet, vol 368, page 124-129)[25] concluded that a 3-day course of nitazoxanide significantly reduced the duration of rotavirus disease in hospitalized pediatric patients. Dose given was "7.5 mg/kg twice daily" and the time of resolution was "31 hours for those given nitazoxanide compared with 75 hours for those in the placebo group." Rotavirus is the most common infectious agent associated with diarrhea in the pediatric age group worldwide.
Teran et al.. conducted a study at the Pediatric Center Albina Patinö, a reference hospital in the city of Cochabamba, Bolivia, from August 2007 to February 2008. The study compared nitazoxanide and probiotics in the treatment of acute rotavirus diarrhea. They found Small differences in favor of nitazoxanide in comparison with probiotics and concluded that nitazoxanide is an important treatment option for rotavirus diarrhea.[17]
Lateef et al.. conducted a study in India that evaluated the effectiveness of nitazoxanide in the treatment of beef tapeworm (Taenia saginata) infection. They concluded that nitazoxanide is a safe, effective, inexpensive, and well-tolerated drug for the treatment of niclosamide- and praziquantel-resistant beef tapeworm (Taenia saginata) infection.[18]
A retrospective review of charts of patients treated with nitazoxanide for trichomoniasis by Michael Dan and Jack D. Sobel demonstrated negative result. They reported three case studies; two of which with metronidazole-resistant infections. In Case 3, they reported the patient to be cured with high divided dose tinidazole therapy. They used a high dosage of the drug (total dose, 14–56 g) than the recommended standard dosage (total dose, 3 g) and observed a significant adverse reaction (poorly tolerated nausea) only with the very high dose (total dose, 56 g). While confirming the safety of the drug, they showed nitazoxanide is ineffective for the treatment of trichomoniasis.[26]
Contraindications
Nitazoxanide is contraindicated only in individuals who have experienced a hypersensitivity reaction to nitazoxanide or the inactive ingredients of a nitazoxanide formulation.[1]
Adverse effects
The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis;[1] these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, and others.[1][27] Nitazoxanide does not appear to cause any significant adverse effects when taken by healthy adults.[1][2]
Overdose
Information on nitazoxanide overdose is limited. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects.[1][2] In various animals, the oral LD50 is higher than 10 g/kg.[1]
Interactions
Due to the exceptionally high plasma protein binding (>99.9%) of nitazoxanide's metabolite, tizoxanide, the concurrent use of nitazoxanide with other highly plasma protein-bound drugs with narrow therapeutic indices (e.g., warfarin) increases the risk of drug toxicity.[1] In vitro evidence suggests that nitazoxanide does not affect the CYP450 system.[1]
Pharmacology
Pharmacodynamics
| This section requires expansion. (January 2016) |
The anti-protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism.[1][8]
It has also been shown to have activity against influenza A virus in vitro.[28] The mechanism appears to be by selectively blocking the maturation of the viral hemagglutinin at a stage preceding resistance to endoglycosidase H digestion. This impairs hemagglutinin intracellular trafficking and insertion of the protein into the host plasma membrane.
Pharmacokinetics
Following oral administration, nitazoxanide is rapidly hydrolyzed to the pharmacologically active metabolite, tizoxanide, which is 99% protein bound.[1][9] Tizoxanide is then glucuronide conjugated into the active metabolite, tizoxanide glucuronide.[1] Peak plasma concentrations of the metabolites tizoxanide and tizoxanide glucuronide are observed 1–4 hours after oral administration of nitazoxanide, whereas nitazoxanide itself is not detected in blood plasma.[1]
Roughly 2⁄3 of an oral dose of nitazoxanide is excreted as its metabolites in feces, while the remainder of the dose excreted in urine.[1] Tizoxanide is excreted in the urine, bile and feces.[1] Tizoxanide glucuronide is excreted in urine and bile.[1]
Physical and chemical properties
| This section requires expansion. (January 2016) |
Nitazoxanide is the prototype member of the thiazolides, which is a drug class of structurally-related broad-spectrum antiparasitic compounds.[4] Nitazoxanide is a light yellow crystalline powder. It is poorly soluble in ethanol and practically insoluble in water.
History
Nitazoxanide was originally discovered in the 1980s by Jean-François Rossignol at the Pasteur Institute. Initial studies demonstrated activity versus tapeworms. In vitro studies demonstrated much broader activity. Dr. Rossignol co-founded Romark Laboratories, with the goal of bringing nitazoxanide to market as an anti-parasitic drug. Initial studies in the USA were conducted in collaboration with Unimed Pharmaceuticals, Inc. (Marietta, GA) and focused on development of the drug for treatment of cryptosporidiosis in AIDS. Controlled trials began shortly after the advent of effective anti-retroviral therapies. The trials were abandoned due to poor enrollment and the FDA rejected an application based on uncontrolled studies.
Rather than abandon their efforts, Romark launched a series of controlled trials. A placebo-controlled study of nitazoxanide in cryptosporidiosis demonstrated significant clinical improvement in adults and children with mild illness. Among malnourished children in Zambia with chronic cryptosporidiosis, a three-day course of therapy led to clinical and parasitologic improvement and improved survival. In Zambia and in a study conducted in Mexico, nitazoxanide was not successful in the treatment of cryptosporidiosis in advanced infection with human immunodeficiency virus at the doses used. However, it was effective in patients with higher CD4 counts. In treatment of giardiasis, nitazoxanide was superior to placebo and comparable to metronidazole. Nitazoxanide was successful in the treatment of metronidazole-resistant giardiasis. Studies have suggested efficacy in the treatment of cyclosporiasis, isosporiasis, and amebiasis.[29]
Pharmaceutical products
Dosage forms
Nitazoxanide is currently available in two oral dosage forms: a tablet (500 mg) and an oral suspension (100 mg per 5 ml when reconstituted).[1]
An extended release tablet (675 mg) has been used in clinical trials for chronic hepatitis C; however, this form is not currently marketed and available for prescription.[21]
Brand names
Nitazoxanide is sold under the brand names Adonid, Alinia, Allpar, Annita, Colufase, Daxon, Dexidex, Kidonax, Mitafar, Netazox, Niazid, Nitamax, Nitax, Nitaxide, Nizonide, NT-TOX, Pacovanton, Paramix, Toza, and Zox.
References
- ^ a b c d e f g h i j k l m n o p q r s t u v w "Nitazoxanide Prescribing Information" (PDF). Romark Pharmaceuticals. August 2013. pp. 1–5. Retrieved 3 January 2016.
- ^ a b c d e Stockis A, Allemon AM, De Bruyn S, Gengler C (May 2002). "Nitazoxanide pharmacokinetics and tolerability in man using single ascending oral doses". Int J Clin Pharmacol Ther 40 (5): 213–220. doi:10.5414/cpp40213. PMID 12051573.
- ^ "Nitazoxanide". PubChem Compound. National Center for Biotechnology Information. Retrieved 3 January 2016.
- ^ a b c d e Di Santo N, Ehrisman J (2013). "Research perspective: potential role of nitazoxanide in ovarian cancer treatment. Old drug, new purpose?". Cancers (Basel) 5 (3): 1163–1176. doi:10.3390/cancers5031163. PMC 3795384. PMID 24202339.
Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity against a wide variety of protozoa and helminths. ... Nitazoxanide (NTZ) is a main compound of a class of broad-spectrum anti-parasitic compounds named thiazolides. It is composed of a nitrothiazole-ring and a salicylic acid moiety which are linked together by an amide bond ... NTZ is generally well tolerated, and no significant adverse events have been noted in human trials [13]. ... In vitro, NTZ and tizoxanide function against a wide range of organisms, including the protozoal species Blastocystis hominis, C. parvum, Entamoeba histolytica, G. lamblia and Trichomonas vaginalis [13]
- ^ White CA (2004). "Nitazoxanide: a new broad spectrum antiparasitic agent". Expert Rev Anti Infect Ther 2 (1): 43–9. doi:10.1586/14787210.2.1.43. PMID 15482170.
- ^ a b c d e f Rossignol JF (October 2014). "Nitazoxanide: a first-in-class broad-spectrum antiviral agent". Antiviral Res. 110: 94–103. doi:10.1016/j.antiviral.2014.07.014. PMID 25108173.
Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the treatment of influenza. ... From a chemical perspective, nitazoxanide is the scaffold for a new class of drugs called thiazolides. These small-molecule drugs target host-regulated processes involved in viral replication. ... A new dosage formulation of nitazoxanide is presently undergoing global Phase 3 clinical development for the treatment of influenza. Nitazoxanide inhibits a broad range of influenza A and B viruses including influenza A(pH1N1) and the avian A(H7N9) as well as viruses that are resistant to neuraminidase inhibitors. ... Nitazoxanide also inhibits the replication of a broad range of other RNA and DNA viruses including respiratory syncytial virus, parainfluenza, coronavirus, rotavirus, norovirus, hepatitis B, hepatitis C, dengue, yellow fever, Japanese encephalitis virus and human immunodeficiency virus in cell culture assays. Clinical trials have indicated a potential role for thiazolides in treating rotavirus and norovirus gastroenteritis and chronic hepatitis B and chronic hepatitis C. Ongoing and future clinical development is focused on viral respiratory infections, viral gastroenteritis and emerging infections such as dengue fever.
- ^ a b Anderson, V. R.; Curran, M. P. (2007). "Nitazoxanide: A review of its use in the treatment of gastrointestinal infections". Drugs 67 (13): 1947–1967. doi:10.2165/00003495-200767130-00015. PMID 17722965.
Nitazoxanide is effective in the treatment of protozoal and helminthic infections ... Nitazoxanide is a first-line choice for the treatment of illness caused by C. parvum or G. lamblia infection in immunocompetent adults and children, and is an option to be considered in the treatment of illnesses caused by other protozoa and/or helminths.
- ^ a b Sisson G1, Goodwin A, Raudonikiene A, Hughes NJ, Mukhopadhyay AK, Berg DE, Hoffman PS. (July 2002). "Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori." (PDF). Antimicrob Agents Chemother. 46 (7): 2116–23. doi:10.1128/aac.46.7.2116-2123.2002. PMC 127316. PMID 12069963.
Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide
- ^ a b Korba BE, Montero AB, Farrar K, et al. (January 2008). "Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication". Antiviral Res. 77 (1): 56–63. doi:10.1016/j.antiviral.2007.08.005. PMID 17888524.
- ^ "Blastocystis: Resources for Health Professionals". United States Centers for Disease Control and Prevention. Retrieved 4 January 2016.
- ^ Roberts T, Stark D, Harkness J, Ellis J (May 2014). "Update on the pathogenic potential and treatment options for Blastocystis sp". Gut Pathog 6: 17. doi:10.1186/1757-4749-6-17. PMC 4039988. PMID 24883113.
Blastocystis is one of the most common intestinal protists of humans. ... A recent study showed that 100% of people from low socio-economic villages in Senegal were infected with Blastocystis sp. suggesting that transmission was increased due to poor hygiene sanitation, close contact with domestic animals and livestock, and water supply directly from well and river [10].&nsp;...
Table 2: Summary of treatments and efficacy for Blastocystis infection - ^ Muñoz P, Valerio M, Eworo A, Bouza E (2011). "Parasitic infections in solid-organ transplant recipients". Curr Opin Organ Transplant 16 (6): 565–575. doi:10.1097/MOT.0b013e32834cdbb0. PMID 22027588. Retrieved 7 January 2016.
Nitazoxanide: intestinal amoebiasis: 500 mg po bid x 3 days
- ^ "Hymenolepiasis: Resources for Health Professionals". United States Centers for Disease Control and Prevention. Retrieved 4 January 2016.
- ^ Hagel I, Giusti T (October 2010). "Ascaris lumbricoides: an overview of therapeutic targets". Infect Disord Drug Targets 10 (5): 349–67. doi:10.2174/187152610793180876. PMID 20701574.
new anthelmintic alternatives such as tribendimidine and Nitazoxanide have proved to be safe and effective against A. lumbricoides and other soil-transmitted helminthiases in human trials.
- ^ Shoff WH (5 October 2015). Chandrasekar PH, Talavera F, King JW, ed. "Cyclospora Medication". Medscape. WebMD. Retrieved 11 January 2016.
Nitazoxanide, a 5-nitrothiazole derivative with broad-spectrum activity against helminths and protozoans, has been shown to be effective against C cayetanensis, with an efficacy 87% by the third dose (first, 71%; second 75%). Three percent of patients had minor side effects.
- ^ Li TC, Chan MC, Lee N (September 2015). "Clinical Implications of Antiviral Resistance in Influenza". Viruses 7 (9): 4929–4944. doi:10.3390/v7092850. PMC 4584294. PMID 26389935.
Oral nitazoxanide is an available, approved antiparasitic agent (e.g., against cryptosporidium, giardia) with established safety profiles. Recently, it has been shown (together with its active metabolite tizoxanide) to possess anti-influenza activity by blocking haemagglutinin maturation/trafficking, and acting as an interferon-inducer [97]. ... A large, multicenter, Phase 3 randomized-controlled trial comparing nitazoxanide, oseltamivir, and their combination in uncomplicated influenza is currently underway (NCT01610245).
Figure 1: Molecular targets and potential antiviral treatments against influenza virus infection - ^ a b Teran, C. G.; Teran-Escalera, C. N.; Villarroel, P. (2009). "Nitazoxanide vs. Probiotics for the treatment of acute rotavirus diarrhea in children: A randomized, single-blind, controlled trial in Bolivian children". International Journal of Infectious Diseases 13 (4): 518–523. doi:10.1016/j.ijid.2008.09.014. PMID 19070525.
- ^ a b Lateef, M.; Zargar, S. A.; Khan, A. R.; Nazir, M.; Shoukat, A. (2008). "Successful treatment of niclosamide- and praziquantel-resistant beef tapeworm infection with nitazoxanide". International Journal of Infectious Diseases 12 (1): 80–82. doi:10.1016/j.ijid.2007.04.017. PMID 17962058.
- ^ World Journal of Gastroenterology 2009 April 21, Emmet B Keeffe MD, Professor,Jean-François Rossignol The Romark Institute for Medical Research, Tampa
- ^ http://www.medhelp.org/posts/Hepatitis-B/alinia/show/1109214
- ^ a b c d e f Keeffe, E. B.; Rossignol, J. F. (2009). "Treatment of chronic viral hepatitis with nitazoxanide and second generation thiazolides". World Journal of Gastroenterology 15 (15): 1805–1808. doi:10.3748/wjg.15.1805. PMC 2670405. PMID 19370775.
- ^ Keeffe, Emmet B. (September 2009). "Current Developments in the Treatment of Hepatitis and Hepatobiliary Disease". Gastroenterol Hepatol (N Y) 5 (9): 620–622. PMC 2886418.
- ^ "Romark Initiates Clinical Trial Of Alinia For Chronic Hepatitis C In The United States" (Press release). Medical News Today. August 16, 2007. Retrieved 2007-10-11.
- ^ Franciscus, Alan (October 2, 2007). "Hepatitis C Treatments in Current Clinical Development". HCV Advocate. Retrieved 2007-10-11.
- ^ Rossignol, Jean-François; Abu-Zekry, Mona; Hussein, Abeer; Santoro, M Gabriella (2006). "Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: randomised double-blind placebo-controlled trial". The Lancet 368 (9530): 124–9. doi:10.1016/S0140-6736(06)68852-1. PMID 16829296.
- ^ Dan, M.; Sobel, J. D. (2007). "Failure of Nitazoxanide to Cure Trichomoniasis in Three Women". Sexually Transmitted Diseases. doi:10.1097/NMD.0b013e31802f5d9a.
- ^ "Nitazoxanide". MedlinePlus. Retrieved 9 April 2014.
- ^ Rossignol, J. F.; La Frazia, S.; Chiappa, L.; Ciucci, A.; Santoro, M. G. (2009). "Thiazolides, a New Class of Anti-influenza Molecules Targeting Viral Hemagglutinin at the Post-translational Level". Journal of Biological Chemistry 284 (43): 29798–29808. doi:10.1074/jbc.M109.029470. PMC 2785610. PMID 19638339.
- ^ White Jr, AC (2003). "Nitazoxanide: An important advance in anti-parasitic therapy". Am. J. Trop. Med. Hyg. 68 (4): 382–383. PMID 12875283.
External links
- "Nitazoxanide". MedlinePlus Drug Information. U.S. National Library of Medicine. 28 July 2010. Retrieved 2010-08-19.
- "Parasitic infections". Am J Transplant 4 (Suppl 10): 142–55. 2004. doi:10.1111/j.1600-6135.2004.00677.x. PMID 15504227.
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. クリプトスポリジウム症の治療および予防 treatment and prevention of cryptosporidiosis
- 2. ジアルジア症の治療および予防 treatment and prevention of giardiasis
- 3. 抗原虫治療 antiprotozoal therapies
- 4. 成人におけるクロストリジウム・ディフィシル：治療 clostridium difficile in adults treatment
- 5. 駆虫薬療法 anthelminthic therapies
English Journal
- Effect of Mass Stool Examination and Mass Treatment For Decreasing Intestinal Helminth and Protozoan Infection Rates in Bolivian Children: A Cross-Sectional Study.
- Asai T1, Còrdova Vidal C2, Strauss W3, Ikoma T4, Endoh K5, Yamamoto M1.
- PLoS neglected tropical diseases.PLoS Negl Trop Dis.2016 Dec 6;10(12):e0005147. doi: 10.1371/journal.pntd.0005147. eCollection 2016.
- Bolivia is one of the countries with a high intestinal helminth and protozoan infection rate. Despite the high prevalence of the parasitic infection, nationwide preventive measures for Bolivian children have not yet been implemented. We evaluated the effect of mass stool examination and treatment as
- PMID 27923058
- Nitazoxanide induces in vitro metabolic acidosis in Taenia crassiceps cysticerci.
- Isac E1, de A Picanço G1, da Costa TL1, de Lima NF1, de S M M Alves D1, Fraga CM1, de S Lino Junior R1, Vinaud MC2.
- Experimental parasitology.Exp Parasitol.2016 Dec;171:17-22. doi: 10.1016/j.exppara.2016.10.012. Epub 2016 Oct 14.
- Nitazoxanide (NTZ) is a broad-spectrum anti-parasitic drug used against a wide variety of protozoans and helminthes. Albendazole, its active metabolite albendazole sulfoxide (ABZSO), is one of the drugs of choice to treat both intestinal and tissue helminth and protozoan infections. However little i
- PMID 27751770
- Chronic Norovirus Infections in Cardiac Transplant Patients: Considerations for Evaluation and Management.
- Jurgens PT1, Allen LA2, Ambardekar AV2, McIlvennan CK3.
- Progress in transplantation (Aliso Viejo, Calif.).Prog Transplant.2016 Nov 23. pii: 1526924816679843. [Epub ahead of print]
- Norovirus is a common self-limiting gastrointestinal infection, but in transplant recipients, symptoms can last for months and result in serious health complications. As there is currently no established treatment for chronic norovirus infection in transplant patients, management has been directed a
- PMID 27881814
Japanese Journal
- Effects of triple-drug therapy with nitazoxanide, high-dose ribavirin and peginterferon-α-2a in patients with chronic hepatitis C
- Hepatology research : the official journal of the Japan Society of Hepatology 43(6), 589-595, 2013-06-01
- NAID 10031194560
- Industrial Info. C型慢性肝炎患者に対するNitazoxanide (NTZ)の効果
- 細胞 41(6), 244-248, 2009-06
- NAID 40016681815
- Liquid chromatography-tandem mass spectrometry analysis of nitazoxanide and its major metabolites in goat
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 875(2), 427-436, 2008-11-15
- NAID 10028009494
Related Links
- Crypto and Cryptosporidium Infection fact sheet about Nitazoxanide. ... References Fox LM, Saravolatz LD. Nitazoxanide: a new thiazolide antiparasitic agent. Clin Infect Dis. 2005 40(8):1173-80. White, AC Jr ...
- Nitazoxanide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain headache upset stomach vomiting discolored urine Some side effects can be serious. If you ...
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