nicotinamide N-methyltransferase

同

NNMT

WordNet

1. the 14th letter of the Roman alphabet (同)n

PrepTutorEJDIC

1. nitrogenの化学記号
2. neodymiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/19 09:46:44」(JST)

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nicotinamide N-methyltransferase
Identifiers
EC number	2.1.1.1
CAS number	9029-74-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a nicotinamide N-methyltransferase (NNMT) (EC 2.1.1.1) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + nicotinamide S-adenosyl-L-homocysteine + 1-methylnicotinamide.

Thus, the two substrates of this enzyme are S-adenosyl methionine and nicotinamide, whereas its two products are S-adenosylhomocysteine and 1-methylnicotinamide.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinamide N-methyltransferase. This enzyme is also called nicotinamide methyltransferase.

Function

This enzyme participates in nicotinate and nicotinamide metabolism.

NNMT affects a biochemical mechanism known as a futile cycle, which plays a role in metabolic regulation. NNMT is found in human fat cells and the liver. NNMT processes vitamin B3 and has been linked with certain types of cancer. Silencing the gene that codes for NNMT reduces its presence and increases the presence of sugar transporter GLUT4.

Mice that produced large amounts of GLUT4 were insulin sensitive and protected against diabetes, while mice with no GLUT4 were insulin resistant and at risk. High levels of NNMT are often found in the fat cells of animals that are insulin resistant. When the researchers silenced the NNMT gene in mice on high-fat diets, the mice gained less weight than those in whom the NNMT gene was functioning normally. (The mice did not change their eating or exercise habits).

Antisense oligonucleotide (ASO) technology can be used to silence the expression of the NNMT gene only in fat and liver cells. ASOs are short strings of DNA that can be designed to prevent the synthesis of specific proteins. ASOs have been approved for use by the U.S. Food and Drug Administration for the treatment of conditions with other genetic causes—such as elevated cholesterol and hyperlipidemia.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2I62 and 2IIP.

References

• Cantoni gl (1951). "Methylation of nicotinamide with soluble enzyme system from rat liver". J. Biol. Chem. 189 (1): 203–16. PMID 14832232. 

UpToDate Contents

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English Journal

• Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway.

• Xie X1,2, Liu H1,2, Wang Y1,2, Zhou Y1,2, Yu H1,2, Li G1,2, Ruan Z1,2, Li F1,2, Wang X1,2, Zhang J1,2.
• Oncotarget.Oncotarget.2016 Jun 13. doi: 10.18632/oncotarget.9962. [Epub ahead of print]
• Nicotinamide N-methyltransferase (NNMT), which converts nicotinamide to 1-methylnicotinamide (1-MNA), is overexpressed in a variety of human cancers and serves as a potential anti-cancer target. In this study, we investigated the effect of NNMT on 5-fluorouracil (5-FU) sensitivity of colorectal canc
• PMID 27323852

• Expression profile and prognostic value of NNMT in patients with pancreatic cancer.

• Xu Y1,2, Liu P3, Zheng DH2, Wu N4, Zhu L5, Xing C6, Zhu J1,7.
• Oncotarget.Oncotarget.2016 Mar 3. doi: 10.18632/oncotarget.7891. [Epub ahead of print]
• The elevation of Nicotinamide N-methyltransferase (NNMT) has been reported in pancreatic cancer tissues and cell lines, but its clinical and prognostic implications remain controversial. This study aimed at investigating the expression of NNMT in pancreatic benign and malignant tissues and the progn
• PMID 26942567

• Nicotinamide N-methyltransferase: a potential biomarker for worse prognosis in gastric carcinoma.

• Chen C1, Wang X2, Huang X2, Yong H2, Shen J2, Tang Q2, Zhu J3, Ni J4, Feng Z5.
• American journal of cancer research.Am J Cancer Res.2016 Feb 15;6(3):649-63. eCollection 2016.
• In clinical practice, cancer stage (or grade) and some biomarkers, such as carcinoembryonic antigen (CEA) and CA199, are widely used to predict the prognosis of gastric carcinoma patients. Due to the limited role of prognostic indicators for gastric carcinoma, this condition remains one of the most
• PMID 27152242

Japanese Journal

• Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese

• MORI Yayoi,SUGAWARA Akiko,TSUJI Masayoshi,KAKAMU Takeyasu,TSUBOI Satoshi,KANDA Hideyuki,HAYAKAWA Takehito,FUKUSHIMA Tetsuhito
• Environmental health and preventive medicine 17(5), 371-376, 2012-09-01
• NAID 10031120510

• Interferon-γ Elevates Nicotinamide N-Methyltransferase Activity and Nicotinamide Level in Human Glioma Cells

• Yamada Kazuo,Miyazaki Takeshi,Hara Nobumasa [他],TSUCHIYA Mikako
• Journal of nutritional science and vitaminology 56(2), 83-86, 2010-04-01
• … Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide. … NNMT is strongly expressed in tumor cells and an increase in NNMT activity may reduce cellular nicotinamide level and thereby promote cell survival in the cells. … However, there has been no report of a relationship between NNMT activity and nicotinamide level in tumor cells. …
• NAID 10026476527

• The Effect of Heavy Metals on Nicotinamide N-methyltransferase Activity In Vitro Relating to Parkinson's Disease

• SUGAWARA Akiko,YOKOYAMA Hiroko,OHTA Mitsuhiro,MAEDA Takafumi,TANAKA Kazuko,FUKUSHIMA Tetsuhito
• Environmental health and preventive medicine 10(4), 180-183, 2005-07-01
• … Objective: The aims of this study were to determine the effects of heavy metals such as manganese on nicotinamide <i>N</i>-methyltransferase (EC 2.1.1.1) (NNMT) activity and to consider the possibility of involvement of NNMT activation in the pathogenesis of heavy metal induced Parkinson's disease.<br> …
• NAID 10016602324

Related Links

• NNMT nicotinamide N-methyltransferase [Homo sapiens (human)]

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.

• Nicotinamide N-methyltransferase: Nicotinamide N ...

GoPubMed lists recent and important papers and reviews for nicotinamide N-methyltransferase(nicotinamide N-methyltransferase) ... Here we show, using DNA array analyses, that nicotinamide N-methyltransferase (Nnmt) is the ...

Related Pictures

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★リンクテーブル★

リンク元	「ニコチンアミド-N-メチル基転移酵素」「ニコチンアミド-N-メチルトランスフェラーゼ」
関連記事	「n」「methyltransferase」「N」「nicotinamide」「methyltransferases」

「ニコチンアミド-N-メチル基転移酵素」

　　[★]

英

nicotinamide N-methyltransferase

関

ニコチンアミド-N-メチルトランスフェラーゼ

「ニコチンアミド-N-メチルトランスフェラーゼ」

　　[★]

英

nicotinamide N-methyltransferase

関

ニコチンアミド-N-メチル基転移酵素

「n」

　　[★]

• n.

• 例数

関

number of experiment、sample size

• pの前の[n]はmと記載する。synptom→symptom

「methyltransferase」

　　[★] メチルトランスフェラーゼ、メチル基転移酵素、メチル化酵素

「N」

　　[★]

• アスパラギン asparagine
• 窒素(原子、分子)

　 　

「nicotinamide」

　　[★] ニコチンアミド、ニコチン酸アミド

「methyltransferases」

　　[★] メチルトランスフェラーゼ