neuroretinitis

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/08 14:01:01」(JST)

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For the Ted Nugent album, see Cat Scratch Fever. For the Nickelodeon cartoon, see Catscratch.

Cat scratch disease
Micrograph of a lymph node affected by cat scratch disease. H&E stain.
Classification and external resources
Specialty	Infectious disease
ICD-10	A28.1
ICD-9-CM	078.3
DiseasesDB	2173
MedlinePlus	001614
eMedicine	emerg/84
Patient UK	Cat-scratch disease
MeSH	D002372

Cat-scratch disease (CSD), also known as cat-scratch fever, Teeny's disease, inoculation lymphoreticulosis, and subacute regional lymphadenitis, is a common and usually benign infectious disease caused by a bacterium, either Bartonella henselae or Bartonella quintana. It is most commonly found in children following a scratch or bite from a cat within about one to two weeks.

Signs and symptoms

Cat-scratch disease commonly presents as tender, swollen lymph nodes near the site of the inoculating bite or scratch or on the neck, and is usually limited to one side. This condition is referred to as regional lymphadenopathy and occurs 1–3 weeks after inoculation. Lymphadenopathy in CSD most commonly occurs in the arms, neck, or jaw, but may also occur near the groin or around the ear. A vesicle or an erythematous papule may form at the site of initial infection. Most patients also develop systemic symptoms such as malaise, decreased appetite, and aches. Other associated complaints include headache, chills, muscular pains, joint pains, arthritis, backache, and abdominal pain. It may take 7 to 14 days, or as long as two months, for symptoms to appear. Most cases are benign and self-limiting, but lymphadenopathy may persist for several months after other symptoms disappear. The disease usually resolves spontaneously, with or without treatment, in one month.

In rare situations, CSD can lead to the development of serious neurologic or cardiac sequelae such as meningoencephalitis, encephalopathy, seizures, or endocarditis. Endocarditis associated with Bartonella infection has a particularly high mortality. Parinaud's oculoglandular syndrome is the most common ocular manifestation of CSD, and is a granulomatous conjunctivitis with concurrent swelling of the lymph node near the ear. Optic neuritis or neuroretinitis is one of the atypical presentations.

Immunocompromised patients are susceptible to other conditions associated with B. henselae and B. quintana, such as bacillary angiomatosis or bacillary peliosis. Bacillary angiomatosis is primarily a vascular skin lesion that may extend to bone or be present in other areas of the body. In the typical scenario, the patient has HIV or another cause of severe immune dysfunction. Bacillary peliosis is caused by B. henselae that most often affects patients with HIV and other conditions causing severe immune compromise. The liver and spleen are primarily affected, with findings of blood-filled cystic spaces on pathology. In 2015 a Toledo, Ohio woman lost eyesight in an eye after a cat licked it.

Cause

Bartonella henselae and B. quintana are fastidious intracellular Gram-negative bacteria.

Transmission

The cat was recognized as the natural reservoir of the disease in 1950 by Robert Debré. Kittens are more likely to carry the bacteria in their blood, and therefore may be more likely to transmit the disease than adult cats. However, fleas serve as a vector for transmission of B. henselae among cats, and viable B. henselae are excreted in the feces of Ctenocephalides felis, the cat flea. Cats could be infected with B. henselae through intradermal inoculation using flea feces containing B. henselae. As a consequence, a likely means of transmission of B. henselae from cats to humans may be inoculation with flea feces containing B. henselae through a contaminated cat scratch wound or by cat saliva transmitted in a bite. Ticks can also act as vectors and occasionally transmit the bacteria to humans. Combined clinical and PCR-based research has shown that other organisms can transmit Bartonella, including spiders. Cryptic Bartonella infection may be a much larger problem than previously thought, constituting an unrecognized occupational health hazard of veterinarians.,

Diagnosis

The Warthin–Starry stain can be helpful to show the presence of B. henselae, but is often difficult to interpret. B. henselae is difficult to culture and can take 2–6 weeks to incubate. The best diagnostic method currently available is polymerase chain reaction, which has a sensitivity of 43-76% and a specificity (in one study) of 100%.

Histology

High-magnification micrograph of CSD showing a granuloma (pale cells - right of center on image) and a microabscess with neutrophils (left of image), H&E stain

Cat-scratch disease is characterized by granulomatous inflammation on histological examination of the lymph nodes. Under the microscope, the skin lesion demonstrates a circumscribed focus of necrosis, surround by histiocytes, often accompanied by multinucleated giant cells, lymphocytes, and eosinophils. The regional lymph nodes demonstrate follicular hyperplasia with central stellate necrosis with neutrophils, surrounded by palisading histiocytes (suppurative granulomas) and sinuses packed with monocytoid B cells, usually without perifollicular and intrafollicular epithelioid cells. This pattern, although typical, is only present in a minority of cases.

Treatment

Most healthy people clear the infection without treatment, and antimicrobial therapy is not recommended for immunocompetent patients with mild to moderate B. henselae disease due to the risk of side effects from antibiotics. Azithromycin, ciprofloxacin, doxycycline, gentamicin, rifampicin, and trimethoprim/sulfamethoxazole have been used, but have demonstrated limited efficacy.

Azithromycin is preferentially used in pregnancy to avoid the teratogenic side effects of doxycycline. However, doxycycline is preferred to treat B. henselae infections with optic neuritis due to its ability to adequately penetrate the tissues of the eye and central nervous system.

Epidemiology

Bartonella henselae is found worldwide and CSD has been observed in many countries. The incidence of CSD appears to have a seasonal relationship, possibly due to the mating behavior of the cat flea during certain times of the year.

History

Symptoms similar to CSD were first described by Henri Parinaud in 1889, and the clinical syndrome was first described in 1950 by Robert Debré. In 1983, the Warthin-Starry silver stain was used to discover a Gram-negative bacillus which was named Afipia felis in 1991 after it was successfully cultured and isolated. The causative organism of CSD was originally believed to be Afipia felis, but this was disproved by immunological studies in the 1990s demonstrating that cat-scratch fever patients developed antibodies to two other organisms, B. henselae (originally known as Rochalimea henselae before the genera Bartonella and Rochalimea were combined) and B. clarridgeiae, which is a rod-shaped Gram-negative bacterium.

References

External links

• CDC information
• DermNet bacterial/catscratch

• Cat Scratch Disease on National Organization for Rare Disorders site
• Cat Scratch Fever Disease
• Cat Scratch Fever

UpToDate Contents

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• 1. 視神経症 optic neuropathies
• 2. ネコ引っかき病の治療 treatment of cat scratch disease
• 3. 視神経炎：病態生理、臨床的特徴、および診断 optic neuritis pathophysiology clinical features and diagnosis
• 4. ネコ引っかき病の微生物学、疫学、臨床症状、および診断 microbiology epidemiology clinical manifestations and diagnosis of cat scratch disease
• 5. 全身性疾患および感染に関連した網膜血管炎 retinal vasculitis associated with systemic disorders and infections

English Journal

• The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.

• Hanke-Gogokhia C1,2, Zhang H3, Frederick JM4, Baehr W5,6,7.
• Advances in experimental medicine and biology.Adv Exp Med Biol.2016;854:655-61. doi: 10.1007/978-3-319-17121-0_87.
• Arf-like proteins (ARLs) are ubiquitously expressed small G proteins of the RAS superfamily. In photoreceptors, ARL2 and ARL3 participate in the trafficking of lipidated membrane-associated proteins and colocalize in the inner segment with UNC119A and PDEδ. UNC119A and PDEδ are acyl- and prenyl-bi
• PMID 26427472

• Regenerative Medicine: Solution in Sight.

• Wang Q1, Stern JH2, Temple S3.
• Advances in experimental medicine and biology.Adv Exp Med Biol.2016;854:543-8. doi: 10.1007/978-3-319-17121-0_72.
• The retina, like other central nervous system tissues, has poor regenerative properties in humans. Therefore, diseases that cause retinal cell loss, such as Age-related macular degeneration (AMD), retinitis pigmentosa (RP), Leber congenital amaurosis, Usher syndrome, glaucoma, and diabetic retinopat
• PMID 26427457

Japanese Journal

• 猫ひっかき病 (特集 見逃されやすい頸部リンパ節腫脹の原因疾患)

• 血液内科 = Hematology 71(3), 376-379, 2015-09
• NAID 40020613667

• A case of paraneoplastic optic neuropathy and outer retinitis positive for autoantibodies against collapsin response mediator protein-5, recoverin, and alpha-enolase

• BMC Ophthalmology 14, 5, 2014-01-16
• NAID 120005438263

• 高校入試直前に発症したネコひっかき病の1例 (特集 第66回日本臨床眼科学会講演集(6))

• 臨床眼科 67(8), 1289-1294, 2013-08
• NAID 40019764682

Related Links

• neuroretinitis - definition of neuroretinitis by Medical dictionary

neuroretinitis /neu·ro·ret·i·ni·tis/ (-ret″ĭ-ni´tis) inflammation of the optic nerve and retina. neu·ro·ret·i·ni·tis (n r-r t n-t s) n. Inflammation of the retina and optic nerve. neuroretinitis [noor″o-ret″ĭ-ni´tis] inflammation of the optic nerve and ...

• Neuroretinitis - EyeWiki

EyeWiki, the Eye Encyclopedia written by Eye Physicians & Surgeons. ... Disease Entity [edit | edit source] Neuroretinitis ICD9 363.05 Disease [edit | edit source] Neuroretinitis is an inflammation of the neural retina and optic nerve.

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