neurokinin receptor antagonist

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1. 制吐剤の特性 characteristics of antiemetic drugs
2. 化学療法誘発性悪心および嘔吐の予防および治療 prevention and treatment of chemotherapy induced nausea and vomiting
3. 化学療法誘発性悪心および嘔吐の病態生理および予測 pathophysiology and prediction of chemotherapy induced nausea and vomiting
4. 診療所ベースの麻酔 office based anesthesia
5. 放射線療法による悪心および嘔吐：予防と治療 radiotherapy induced nausea and vomiting prophylaxis and treatment

Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation and Increasing Early Cardiovascular Function.

Mella JR1, Chiswick E, Stepien D, Moitra R, Duffy ER, Stucchi A, Remick D.
Critical care medicine.Crit Care Med.2017 Feb;45(2):e213-e221. doi: 10.1097/CCM.0000000000002075.
OBJECTIVES: Sepsis remains a serious clinical problem despite intensive research efforts and numerous attempts to improve outcome by modifying the inflammatory response. Substance P, the principal ligand for the neurokinin-1 receptor, is a potent proinflammatory mediator that exacerbates inflammator
PMID 27632670

Pharmacodynamic evaluation of Lys5, MeLeu9, Nle10-NKA(4-10) prokinetic effects on bladder and colon activity in acute spinal cord transected and spinally intact rats.

Kullmann FA1, Katofiasc M2, Thor KB2, Marson L3.
Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2017 Feb;390(2):163-173. doi: 10.1007/s00210-016-1317-4. Epub 2016 Nov 26.
The purpose of this study was to determine feasibility of a novel therapeutic approach to drug-induced voiding after spinal cord injury (SCI) using a well-characterized, peptide, neurokinin 2 receptor (NK2 receptor) agonist, Lys5, MeLeu9, Nle10-NKA(4-10) (LMN-NKA). Cystometry and colorectal pressure
PMID 27889808

Differential effects of aprepitant, a clinically used neurokinin-1 receptor antagonist on the expression of conditioned psychostimulant versus opioid reward.

Mannangatti P1, Sundaramurthy S1, Ramamoorthy S1, Jayanthi LD2.
Psychopharmacology.Psychopharmacology (Berl).2017 Feb;234(4):695-705. doi: 10.1007/s00213-016-4504-6. Epub 2016 Dec 24.
RATIONALE: Neurokinin-1 receptor (NK1R) signaling modulates behaviors associated with psychostimulants and opioids. Psychostimulants, such as amphetamine (AMPH) and cocaine, bind to monoamine transporters and alter their functions. Both dopamine and norepinephrine transporters are regulated by NK1R
PMID 28013351

Antiemetic Effects of a Potent and Selective Neurokinin-1 Receptor Antagonist, FK886, on Cisplatin- and Apomorphine-Induced Emesis in Dogs

Volume Transmission of Substance P in Striatum Induced by Intraplantar Formalin Injection Attenuates Nociceptive Responses via Activation of the Neurokinin 1 Receptor

Nakamura Yoki,Izumi Hiroki,Shimizu Takumi,Hisaoka-Nakashima Kazue,Morioka Norimitsu,Nakata Yoshihiro
Journal of Pharmacological Sciences 121(4), 257-271, 2013
… A slow-onset but significant increase of SP and neurokinin 1 receptor (NK1R) internalization in the contralateral striatum were observed following the second phase of formalin-induced nociceptive behaviors. … Moreover, these anti-nociceptive effects of SP were completely inhibited by co-treatment with the NK1R antagonist CP96345. …
NAID 130003362690