Structural and functional characterization of NanU, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling Bacteroidetes species.
Phansopa C1, Roy S1, Rafferty JB2, Douglas CW1, Pandhal J3, Wright PC3, Kelly DJ2, Stafford GP1.
The Biochemical journal.Biochem J.2014 Mar 15;458(3):499-511. doi: 10.1042/BJ20131415.
Many human-dwelling bacteria acquire sialic acid for growth or surface display. We identified previously a sialic acid utilization operon in Tannerella forsythia that includes a novel outer membrane sialic acid-transport system (NanOU), where NanO (neuraminate outer membrane permease) is a putative
PloS one.PLoS One.2014 May 9;9(5):e96976. doi: 10.1371/journal.pone.0096976. eCollection 2014.
N-acetyl neuraminate lyases (NALs) catalyze the reversible aldol cleavage of N-acetyl neuraminic acid (Neu5Ac) to pyruvate and N-acetyl-D-mannosamine (ManNAc). Previous phylogenetic studies divided NALs into four different groups. Groups 1 and 2 have been well characterized at both kinetic and molec
A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS).
Akiyama Y1, Takeuchi Y, Kikuchi K, Mishima E, Yamamoto Y, Suzuki C, Toyohara T, Suzuki T, Hozawa A, Ito S, Soga T, Abe T.
Toxins.Toxins (Basel).2012 Nov 14;4(11):1309-22. doi: 10.3390/toxins4111309.
The oral adsorbent AST-120 is composed of spherical carbon particles and has an adsorption ability for certain small-molecular-weight compounds that accumulate in patients with chronic kidney disease (CKD). So far, very few compounds are known to be adsorbed by AST-120 in vivo. To examine the effect
Comparison of Substrate Specificities of Sialidase Activity between Purified Enzymes from Influenza Virus A (H1N1 and H3N2 Subtypes) and B Strains and Their Original Viruses
… The optimum pH of purified sialidases from A/PR8,A/Guizhou and B/Ibaraki against sodium p-nitrophenyl-N-acetyl-α-D-neuraminate were 6.5,7.5 and 5.5,respectively. …
Inhibition of Influenza Virus Sialidase and Anti-influenza Virus Activity by Plant Flavonoids
永井 隆之,宮一 輸起範,富森 毅,鈴木 雄次郎,山田 陽城
Chemical & pharmaceutical bulletin 38(5), 1329-1332, 1990-05-25
… Flavonoids (103 species) were tested for inhibitory activity against influenza virus sialidase using sodium p-nitrophenyl-N-acetyl-α-D-neuraminate as substrate. …
A collection of model organism databases of metabolic pathways, including reactions, enzymes, genes and substrate compounds ... Chemical Formula: C 20 H 29 N 4 O 16 P Molecular Weight: 612.44 Daltons Monoisotopic ...
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