neural degenerative disorder

神経変性疾患

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• 1. 小児の双極性障害：疫学および発症機序pediatric bipolar disorder epidemiology and pathogenesis [show details]
  …proposes that genes associated with bipolar disorder give rise to aberrant prefrontal-subcortical neural networks, which lead to abnormal mood regulation that is reinforced by environmental stress and maladaptive …
• 2. 成人における転換性障害：疫学、病因、および予後conversion disorder in adults epidemiology pathogenesis and prognosis [show details]
  …symptoms to recognizable disease or to irrelevant radiologic or laboratory findings (eg, age-related degenerative changes in the vertebrae) . In addition, conversion symptoms may be perpetuated by physical deconditioning … Conversion disorder may involve abnormalities in neural networks of grey matter brain regions rather than a disturbance in one specific structure .…
• 3. 成人のため込み障害：疫学、発症機序、臨床症状、経過、評価、診断hoarding disorder in adults epidemiology pathogenesis clinical manifestations course assessment and diagnosis [show details]
  … The neural substrates of hoarding behavior in nonhuman animals are well established,… The neuroimaging literature of hoarding due to causes other than brain lesions or degenerative disorders (ie,…
• 4. 成人におけるパニック障害：疫学、病因、臨床症状、経過、評価および診断panic disorder in adults epidemiology pathogenesis clinical manifestations course assessment and diagnosis [show details]
  …gamma-aminobutyric acid [GABA]) linked with commonly prescribed anti-panic medications, to proposed neural circuitry closely linked with basic animal models of fear development . This proposed neuroanatomical …
• 5. 協調運動発達障害：臨床的特徴および診断developmental coordination disorder clinical features and diagnosis [show details]
  …neurologic or neuromuscular condition affecting movement (eg, cerebral palsy, muscular dystrophy, degenerative disorder) Although the DSM criteria often are used for clinical diagnosis, the diagnostic criteria …

English Journal

• iPSCs-derived nerve-like cells from familial Alzheimer's disease PSEN 1 E280A reveal increased amyloid-beta levels and loss of the Y chromosome.

• Mendivil-Perez M, Velez-Pardo C, Kosik KS, Lopera F, Jimenez-Del-Rio M.
• Neuroscience letters. 2019 Jun;703()111-118.
• Alzheimer's disease (AD) is a progressive, degenerative disorder that mainly results in memory loss and a cognitive disorder. Although the cause of AD is still unknown, a minor percentage of AD cases are produced by genetic mutations in the presenilin-1 (PSEN1) gene. Differentiated neuronal cells de
• PMID 30904577

• 3D genomic regulation of lncRNA and Xist in X chromosome.

• Yan F, Wang X, Zeng Y.
• Seminars in cell & developmental biology. 2019 Jun;90()174-180.
• Long noncoding RNAs (lncRNAs) act as important regulators in cardiovascular diseases, neural degenerative disease, or cancers, by localizing and spreading across chromatins. lncRNA can regulate the 3D architecture of the enhancer cluster at the target gene locus, relevant to analogous lncRNA-protein
• PMID 30017906

• The evaluation of gravitational recognition in patients with spinocerebellar degeneration using Listing's plane.

• Takeda T, Ikeda T, Tsutsumi T.
• Acta oto-laryngologica. 2019 May;()1-7.
• The thickness of Listing's plane accurately reflects gravitational recognition, constructed through the integration of visual, vestibular, and proprioceptive sensory input in the neural integrator of the central nervous system. Spinocerebellar degeneration (SCD) is a progressive degenerative disease
• PMID 31107126

Japanese Journal

• Fear circuitと不安症

• 関口 正幸
• 不安症研究 10(1), 2-9, 2018
• <p>近年，条件付けにより獲得される連合学習型の恐怖記憶（条件性恐怖記憶）に関する神経科学的研究が盛んであり，その結果として，いわゆる「恐怖神経回路（Fear circuit）」について理解が進みつつある。Fear circuitの制御不全は不安症に関係している可能性が考えられており，この観点から，このcircuitとこれを制御する生体システムの理解についての重要性は高まりつつある。本 …
• NAID 130007554197

• FMR1遺伝子前異変の神経画像研究

• 橋本 龍一郎
• 日本生物学的精神医学会誌 23(1), 15-21, 2012
• FMR1（fragile X mental retardation 1）は，遺伝性の精神発達障害である脆弱X症候群（fragile X syndrome）の原因として知られているが，近年，同遺伝子の前変異（premutation）キャリアにおいて，FXTAS（fragile-X associated tremor and ataxia syndrome）とよばれる主に中年期以降に発症する運動障害・ …
• NAID 130005395423

• Paraneoplastic Neurologic Syndromes

• Hirose Genjiro
• Internal medicine 35(12), 925-929, 1996-12-01
• … Paraneoplastic neurologic syndromes are degenerative diseases of the central or peripheral nervous system that develop in association with a systemic neoplasm without a direct invasion by tumor. …
• NAID 10007004917

Related Links

• Degenerative Nerve Diseases - MedlinePlus - Health ...

Degenerative nerve diseases affect many of your body's activities, such as balance, movement, talking, breathing, and heart function. Many of these diseases are genetic. Sometimes the cause is a medical condition such as ...

• What? | JPND

Neurodegenerative disease is an umbrella term for a range of conditions which primarily affect the neurons in the human brain. Neurons are the building blocks of the nervous system which includes the brain and spinal cord. Neurons ...

• A to Z List of Neurological Disorders - Disabled World

Cerebro-Oculo-Facio-Skeletal Syndrome - (COFS) is a pediatric, genetic, degenerative disorder that involves the brain and the spinal cord. It is characterized by craniofacial and skeletal abnormalities, severely reduced muscle ...

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★リンクテーブル★

リンク元	「神経変性疾患」
関連記事	「disorder」「neural」「degenerative」

「神経変性疾患」

　　[★]

英

neurodegenerative disease, neurodegenerative diseases, neural degenerative disorder, degenerative cerebellar disease, degenerative neurologic disease, neurologic degenerative disease, nervous system degenerative disease

関

中枢神経変性疾患

• 筋萎縮性側索硬化症 amyotrophic lateral sclerosis ALS
• 脊髄性進行性筋萎縮症 spinal progressive muscular atrophy SPMA SMA

• I型 Werding-Hoffmann disease ウエルドニッヒ・ホフマン病
• II型
• III型 Kugelberg-Welander disease クーゲルベルク・ウェランダー病

• 球脊髄性筋萎縮症 spinal bulbar muscular atrophy SBMA Kennedy-Alter-Sung disease ケネディ・オルター・スン症候群

「disorder」

　　[★]

• 障害：個人的苦痛や機能の障害があるので「疾病」とは言えるものの、その背景にある臓器障害がもう一つはっきりしない場合に用いられる。(PSY.9)

• n.

• an untidy state; a lack of order or organization (⇔order)
• violent behaviour of large groups of people
• an illness that cause a part of the body to stop functioning correctly

• 注意

disease <> illness <> disorder

• vt.

• 乱す、乱雑にする。(人)の(心身の)調子を狂わせる。

• vi.

　 　 　 　

「neural」

　　[★]

• adj.

• 神経の、神経性の、神経型の

関

nerve、nervi、nervosa、nervous、nervus、neurally、neuro、neurogenic、neurologic、neurological、neuron、neuronal、neuronally

　 　

「degenerative」

　　[★]

• adj.

• 対価的な、退行性の。堕落させる。変性の

関

degenerate、degeneration、denaturation、denature、involutional、regressive、retrogressive、unfolding