- 関
- islet cell adenoma、islet cell tumor
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/25 01:28:21」(JST)
[Wiki en表示]
| Islet cell carcinoma |
| Classification and external resources |
A symptomatic patient with pheochromocytoma and islet cell tumor of the pancreas. A small right pheochromocytoma with a necrotic center (P) is seen. In addition, an intensely enhancing mass is present in the neck of the pancreas (I). Two small pancreatic cysts are also seen but the bulk of the pancreas is spared. |
| ICD-O: |
M8150/3 |
| MeSH |
D018273 |
Islet cell carcinoma or nesidioblastoma is an uncommon cancer of the endocrine pancreas.
It accounts for approximately 1.3% of pancreatic cancer.[1]
The term "nesidioblastoma" dates to at least 1938.[2]
Survival
Survival in islet cell carcinoma is highly dependent upon the degree of disease involvement; surgical cure is possible if the tumor is resected completely. Review articles using the Surveillance Epidemiology and End Results (SEER) national database have shown a median survival of about a decade for localized disease, six years for regional (confined to the region of the pancreas) and two years for those with distant disease.[3]
See also
References
- ^ Yao JC, Eisner MP, Leary C, et al. (Dec 2007). "Population-based study of islet cell carcinoma". Ann. Surg. Oncol. 14 (12): 3492–500. doi:10.1245/s10434-007-9566-6. PMC 2077912. PMID 17896148.
- ^ Laidlaw GF (1938). "Nesidioblastoma, the islet tumor of the pancreas". Am J Pathol. 14 (2): 125–34. PMC 1964945. PMID 19970380.
- ^ American Society of Clinical Oncology.
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Tumors: digestive system neoplasia (C15–C26/D12–D13, 150–159/211)
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| GI tract |
| Upper GI tract |
| Esophagus |
- Squamous cell carcinoma
- Adenocarcinoma
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| Stomach |
- Gastric carcinoma
- Signet ring cell carcinoma
- Gastric lymphoma
- Linitis plastica
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| Lower GI tract |
| Small intestine |
|
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| Appendix |
- Carcinoid
- Pseudomyxoma peritonei
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| Colon/rectum |
- colorectal polyp: Peutz–Jeghers syndrome
- Juvenile polyposis syndrome
- Familial adenomatous polyposis/Gardner's syndrome
- Cronkhite–Canada syndrome
- neoplasm: Adenocarcinoma
- Familial adenomatous polyposis
- Hereditary nonpolyposis colorectal cancer
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| Anus |
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| Upper and/or lower |
- Gastrointestinal stromal tumor
- Krukenberg tumor (metastatic)
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| Accessory |
| Liver |
- malignant: Hepatocellular carcinoma
- Hepatoblastoma
- benign: Hepatocellular adenoma
- Cavernous hemangioma
- hyperplasia: Focal nodular hyperplasia
- Nodular regenerative hyperplasia
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| Biliary tract |
- bile duct: Cholangiocarcinoma
- Klatskin tumor
- gallbladder: Gallbladder cancer
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| Pancreas |
- exocrine pancreas: Adenocarcinoma
- Pancreatic ductal carcinoma
- cystic neoplasms: Serous microcystic adenoma
- Intraductal papillary mucinous neoplasm
- Mucinous cystic neoplasm
- Solid pseudopapillary neoplasm
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| Peritoneum |
- Primary peritoneal carcinoma
- Peritoneal mesothelioma
- Desmoplastic small round cell tumor
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anat (t, g, p)/phys/devp/enzy
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noco/cong/tumr, sysi/epon
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proc, drug (A2A/2B/3/4/5/6/7/14/16), blte
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Tumors: endocrine gland neoplasia (C73–C75/D34–D35, 193–194/226–227)
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Pancreas/
islets of Langerhans |
- neuroendocrine tumors/islet cell carcinoma: α: Glucagonoma
- β: Insulinoma
- δ: Somatostatinoma
- G: Gastrinoma
- VIPoma
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Hypothalamic/
pituitary axes
+parathyroid |
| Pituitary |
- Pituitary adenoma: Prolactinoma
- ACTH-secreting pituitary adenoma
- GH-secreting pituitary adenoma
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| Thyroid |
- Thyroid cancer (malignant): epithelial cell carcinoma
- Papillary
- Follicular/Hurthle cell
- parafollicular cell
- Anaplastic
- Lymphoma
- Squamous cell carcinoma
- Benign: Thyroid adenoma
- Struma ovarii
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| Parathyroid |
- Parathyroid adenoma
- Parathyroid carcinoma
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| Adrenal tumor |
- adrenal cortex
- Adrenocortical adenoma
- Adrenocortical carcinoma
- adrenal medulla
- Pheochromocytoma
- Neuroblastoma
- see also: Paraganglioma
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| Gonads |
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| Pinealoma |
- Pinealoblastoma
- Pineocytoma
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| MEN |
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noco (d)/cong/tumr, sysi/epon
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proc, drug (A10/H1/H2/H3/H5)
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English Journal
- The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo.
- Luo X1, Li T1, Zhu Y1, Dai Y1, Zhao J1, Guo ZY2, Wang MW1.
- The Biochemical journal.Biochem J.2015 Mar 15;466(3):467-73. doi: 10.1042/BJ20141113.
- Insulin-like peptide 5 (INSL5), a member of the insulin/relaxin superfamily, can activate the G-protein-coupled receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), but its precise biological functions are largely unknown. Recent studies suggest that INSL5/RXFP4 is involved in the contro
- PMID 25514935
- Background data of spontaneous tumors in F344/DuCrlCrlj rats.
- Takanobu K1, Aiso S, Umeda Y, Senoh H, Saito M, Katagiri T, Ikawa N, Ishikawa H, Mine T, Take M, Haresaku M, Matsumoto M, Fukushima S.
- Sangyo eiseigaku zasshi = Journal of occupational health.Sangyo Eiseigaku Zasshi.2015 Mar 9. [Epub ahead of print]
- Introduction: We investigated the 2-year survival rate and incidence of spontaneous tumors in F344/DuCrlCrlj rats used in carcinogenicity studies of chemical substances. Records for animals used in the control groups of carcinogenicity studies which were conducted during the last 10 years were obtai
- PMID 25753608
- Long-term results of the surgical management of insulinoma patients with MEN1: a Groupe d'étude des Tumeurs Endocrines (GTE) retrospective study.
- Vezzosi D1, Cardot-Bauters C1, Bouscaren N1, Lebras M1, Bertholon-Grégoire M1, Niccoli P1, Levy-Bohbot N1, Groussin L1, Bouchard P1, Tabarin A1, Chanson P1, Lecomte P1, Guilhem I1, Carrere N1, Mirallié E1, Pattou F1, Peix JL1, Goere D1, Borson-Chazot F1, Caron P1, Bongard V1, Carnaille B1, Goudet P1, Baudin E2.
- European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2015 Mar;172(3):309-19. doi: 10.1530/EJE-14-0878. Epub 2014 Dec 23.
- OBJECTIVE: Management of insulinomas in the context of MEN1 remains poorly studied. The aim of this study was to evaluate long-term results of various surgical approaches in a large cohort of insulinoma-MEN1 patients.DESIGN AND METHODS: Consecutive insulinoma-MEN1 patients operated on for a nonmetas
- PMID 25538206
Japanese Journal
- 成人発症ｎｅｓｉｄｉｏｂｌａｓｔｏｓｉｓによる難治性低血糖症に対してジアゾキサイドが長期にわたり有効であった１例
- 新生 忠司,岡田 洋右,吉村 暁子,西田 啓子,田中 良哉
- 糖尿病 53(11), 803-809, 2010
- 症例は58歳男性．2002年より夕食前の集中力低下を自覚し，2003年に空腹時低血糖を指摘され当科入院．画像検査では腫瘤影は認められなかったが，IRI/PG比は0.8-1.0と高インスリン性低血糖を認め，ASVSの結果より膵体部微小インスリノーマと考え膵亜全摘術施行．切除膵の病理所見にてnesidioblastosisと診断されたが，術後もインスリン過剰分泌に改善なく空腹時血糖値30～40 mg/ …
- NAID 130004511207
- 加齢に伴い組織学的に成熟化の変化を示した Nesidioblastosis の1例
- 米倉 竹夫,窪田 昭男,今野 元博,保木 昌徳,加藤 道男,大柳 治正,井村 賢治,位田 忍,中山 雅弘,虫明 聡太郎
- 日本小児外科学会雑誌 33(1), 79-85, 1997-02-20
- Nesidioblastosis (NB)におけるnatural history とその組織所見の変化の関連をみるために,生後2ヵ月と8歳時に膵切除を行ったNB症例の組織学的検討を行った.症例は出生前に Beckwith-Wiedemann 症候群と診断された女児で,出生直後より高インシユリン血症を伴った低血糖症を認めた.生後2ヵ月目に開腹術を行ったところ,膵体部に3cm大の腫瘤を認めたため fo …
- NAID 110002091583
- 林 幹彌
- 日本臨床外科医学会雑誌 40(1), 120-124, 1979
- … 合織被膜で被われ,周囲組織から区画されていた.しかし腫瘍内部では豊富な間質内に腫瘍細胞が巣状ないし島嶼状に浸潤性発育を示し悪性腫瘍の像を呈していた.腫瘍細胞は場所により腺管構造をとり粘液を産生し,その一部で膵島芽細胞への分化を示し増殖しており,血管内,リンパ腔内にも腫瘍細胞が認められた.このような所見から本腫瘍はZollinger Ellison症候群を呈した悪性膵島芽細胞腫(malignant nesidioblastoma)と診断さた. …
- NAID 130003595353
Related Links
- Islet cell carcinoma or nesidioblastoma is an uncommon cancer of the endocrine pancreas. It accounts for approximately 1.3% of pancreatic cancer. The term " nesidioblastoma" dates to at least 1938.
- [Source] A nesidioblastoma or islet cell carcinoma is a rare type of cancer of the pancreas...
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- 英
- nesidioblastoma
- 関
- 膵島細胞腺腫、膵島細胞腫瘍