WordNet

kidney disease that is usually associated with hypertension; sclerosis of the renal arterioles reduces blood flow that can lead to kidney failure and heart failure (同)nephroangiosclerosis

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/12 16:05:58」(JST)

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Hypertensive nephropathy (or "hypertensive nephrosclerosis", or "Hypertensive renal disease") is a medical condition referring to damage to the kidney due to chronic high blood pressure. It should be distinguished from "renovascular hypertension" (I15.0), which is a form of secondary hypertension.

In the kidneys, as a result of benign arterial hypertension, hyaline (pink, amorphous, homogeneous material) accumulates in the wall of small arteries and arterioles, producing the thickening of their walls and the narrowing of the lumina — hyaline arteriolosclerosis. Consequent ischemia will produce tubular atrophy, interstitial fibrosis, glomerular alterations (smaller glomeruli with different degrees of hyalinization - from mild to sclerosis of glomeruli) and periglomerular fibrosis. In advanced stages, renal failure will occur. Functional nephrons have dilated tubules, often with hyaline casts in the lumens. Additional complications often associated with hypertensive nephropathy include glomerular damage resulting in proteinuria and hematuria.

External links

Photo at Atlas of Pathology
Tylicki L, Rutkowski B (2003). "[Hypertensive nephropathy: pathogenesis, diagnosis and treatment]". Pol. Merkur. Lekarski (in Polish) 14 (80): 168–73. PMID 12728683.
Luft FC (October 2000). "Hypertensive nephrosclerosis-a cause of end-stage renal disease?". Nephrol Dial Transplant. 15 (10): 1515–7. doi:10.1093/ndt/15.10.1515. PMID 11007815.

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1. 高血圧性腎硬化症の臨床的特徴、診断および治療 clinical features diagnosis and treatment of hypertensive nephrosclerosis
2. 糖尿病性腎症の概要 overview of diabetic nephropathy
3. 老化する腎臓 the aging kidney
4. アテローム性腎動脈狭窄に起因する慢性腎疾患の臨床症状および診断 clinical manifestations and diagnosis of chronic kidney disease resulting from atherosclerotic renal artery stenosis
5. 成人の非糖尿病性慢性腎臓病患者に対する降圧療法と病状の進展 antihypertensive therapy and progression of nondiabetic chronic kidney disease in adults

English Journal

Prevalence of Fabry disease in dialysis patients: Japan Fabry disease screening study (J-FAST).

Saito O1, Kusano E, Akimoto T, Asano Y, Kitagawa T, Suzuki K, Ishige N, Akiba T, Saito A, Ishimura E, Hattori M, Hishida A, Guili C, Maruyama H, Kobayashi M, Ohashi T, Matsuda I, Eto Y.
Clinical and experimental nephrology.Clin Exp Nephrol.2015 Jul 22. [Epub ahead of print]
BACKGROUND: In Fabry disease, progressive glycolipid accumulation leads to damage in kidney and other organs. This study was designed to determine the prevalence rate of Fabry disease in Japanese dialysis patients.METHODS: All dialysis patients agreeing to Japan Fabry disease screening study (J-FAST
PMID 26197777

Intrarenal and Urinary Th9 and Th22 Cytokine Gene Expression in Lupus Nephritis.

Luk CC1, Tam LS1, Kwan BC1, Wong PC1, Ma TK1, Chow KM1, Lai FM1, Li PK1, Szeto CC2.
The Journal of rheumatology.J Rheumatol.2015 Jul;42(7):1150-5. doi: 10.3899/jrheum.140954. Epub 2015 May 15.
OBJECTIVE: We studied the urinary sediment mRNA level of Th9- and Th22-related cytokines in patients with systemic lupus erythematosus (SLE).METHODS: We quantified urinary mRNA levels of interleukin (IL) 9, IL-10, IL-22, and their corresponding transcription factors in 73 patients with active lupus
PMID 25979722

Patients with biopsy-proven nephrosclerosis and moderately impaired renal function have a higher risk for cardiovascular disease: 15 years' experience in a single, kidney disease center.

Suzuki H1, Kobayashi K2, Ishida Y2, Kikuta T2, Inoue T2, Hamada U3, Okada H2.
Therapeutic advances in cardiovascular disease.Ther Adv Cardiovasc Dis.2015 Jun;9(3):77-86. doi: 10.1177/1753944715578596. Epub 2015 Apr 1.
BACKGROUND: Nephrosclerosis progresses slowly to end-stage renal disease (ESRD) in only a small percentage of patients. However, because hypertension and nephrosclerosis are normally found simultaneously, nephrosclerosis is a risk factor for cardiovascular disease (CVD). In turn, the onset of CVD ma
PMID 25838316

Japanese Journal

糖尿病性腎症と高血圧性腎硬化症の病理診断への手引き

佐藤博,鈴木芳樹,北村博司 [他]
The Japanese journal of nephrology = 日本腎臓学会誌 57(4), 649-725, 2015
NAID 40020503067

保存的治療にて救命し得たラミブジン誘発横紋筋融解症合併B型慢性肝炎急性増悪の1例

林秀美,澤田康司,長谷部拓夢 [他],中嶋駿介,阿部真美,細木弥生,大竹孝明,藤井常志,藤谷幹浩,高後裕,長谷部千登美
肝臓 56(7), 341-347, 2015
症例は50歳，男性．2006年頃からB型慢性肝炎，脂質異常症，腎硬化症，高血圧，痛風で近医に通院していたが，抗ウイルス療法は施行されていなかった．2014年2月から肝機能障害の悪化を認め，2014年4月に全身倦怠感が出現し，B型慢性肝炎急性増悪と診断された．エンテカビル投与後に腎機能障害を認めたため，ラミブジン（LAM）投与に変更，15日後にaspartate aminotransferase（A …
NAID 130005090877

高血圧性腎硬化症 (第5土曜特集腎臓病のすべて) -- (腎臓病各論 : 診断とエビデンスに基づいた治療)

伊藤貞嘉
医学のあゆみ 249(9), 789-795, 2014-05-31
NAID 40020071449

Related Pictures

★リンクテーブル★

リンク元

「腎硬化症」

Hypertensive nephropathy
	Classification and external resources
	Micrograph showing renal arterial hyalinosis - pink ring right-of-centre. PAS stain.
ICD-10	I12
ICD-9	403

　　[★]

英: nephrosclerosis
関: [[]]

概念

腎血管病変に伴う血流障害の結果、糸球体の硬化・硝子化、尿細管萎縮、間質結合組織の増加を来し、腎が硬化した状態。

分類

比較

	動脈性腎硬化症	良性腎硬化症	悪性腎硬化症
	老人性腎硬化症	良性腎硬化症	悪性腎硬化症
原疾患	粥状硬化症	高血圧	悪性高血圧症がほとんど
病理	腎動脈やその分枝などの粥状硬化内腔の狭小化や内膜断裂腎組織は虚血性の萎縮像	小細動脈硬化(細動脈硬化)による内腔の狭窄とその灌流域のネフロンの萎縮小葉間動脈や糸球体輸入動脈に硬化が見られる (⇔糖尿病性の場合には輸出細動脈にも認められる) 硝子様細動脈硬化、線維増殖性内膜肥厚病変の進行と共に腎萎縮腎表面は細顆粒状	腎の細動脈にフィブリノイド壊死と増殖性動脈内膜炎
腎機能	健常な腎実質が残存	腎機能は軽度～中等度で、比較的末期まで腎機能は保たれる	高度の腎機能低下が急速に進展
検査		(細動脈性腎硬化症)タンパク尿：軽度(1日1g以上はまれ)。尿沈渣：正常～軽微な変化

匿名

検索

案内

案内

nephrosclerosis