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1. 常染色体優性間質性腎臓病（髄質嚢胞性腎疾患） autosomal dominant interstitial kidney disease medullary cystic kidney disease

English Journal

Evolution of the urinary proteome during human renal development and maturation.

Wang Z1, Li M.
Advances in experimental medicine and biology.Adv Exp Med Biol.2015;845:95-101. doi: 10.1007/978-94-017-9523-4_10.
Renal development process in human is divided into 3 successive stages: pronephros, mesonephros, and metanephros. The tubules continue to mature for 1-2 year after birth. Research of urinary proteome during human renal development is still lacking. Most urine proteome studies focus on postnatal rena
PMID 25355573

Charlton JR1, Springsteen CH, Carmody JB.
Pediatric nephrology (Berlin, Germany).Pediatr Nephrol.2014 Dec;29(12):2299-308. doi: 10.1007/s00467-014-2758-y. Epub 2014 Feb 1.
Although there is wide variation, humans possess on average 900,000 nephrons per kidney. So far as is known, nephrons cannot regenerate; therefore, an individual's nephron endowment has profound implications in determining his or her long-term risk of developing chronic kidney disease. Most of the v
PMID 24488483

Pax2 may play a role in kidney development by regulating the expression of TBX1.

Jiang H1, Li L, Yang H, Bai Y, Jiang H, Li Y.
Molecular biology reports.Mol Biol Rep.2014 Nov;41(11):7491-8. doi: 10.1007/s11033-014-3639-y. Epub 2014 Aug 9.
Renal anomaly is commonly found among patients with loss of TBX1 gene, encoding an important transcriptional factor implicated in numerous developmental processes. Pax2 is a member of the "paired-box" (PAX) family of homeotic genes that orchestrates the patterns of gene expression in specific cells
PMID 25106525

LGR4 Is Required for the Cell Survival of the Peripheral Mesenchyme at the Embryonic Stages of Nephrogenesis

MOHRI Yasuaki,OYAMA Kazunori,SONE Mizuki,AKAMATSU Atsushi,NISHIMORI Katsuhiko
Bioscience, biotechnology, and biochemistry 76(5), 888-891, 2012-05-23
In mice, homozygous Lgr4 inactivation results in hypoplastic kidneys. To understand better the role of LGR4 in kidney development, we performed an analysis of kidneys in Lgr4-/- embryos. We stained Lg …
NAID 10030752442