新生児禁断症候群
WordNet
- the trait of abstaining (especially from alcohol) (同)abstention
- act or practice of refraining from indulging an appetite
- a pattern of symptoms indicative of some disease
- a complex of concurrent things; "every word has a syndrome of meanings"
- relating to or affecting the infant during the first month after birth; "neonatal care"; "the neonatal period"
PrepTutorEJDIC
- (特に宗教的な理由による)(飲食の)禁欲,節制《+『from』+『名』(do『ing』)》
- (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
- 新生児の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/08 16:18:32」(JST)
[Wiki en表示]
| Neonatal withdrawal |
| Classification and external resources |
| ICD-10 |
P96.1 |
| ICD-9 |
779.5 |
| DiseasesDB |
33462 |
| MedlinePlus |
007313 |
| eMedicine |
article/978763 |
| MeSH |
D009357 |
Neonatal withdrawal or neonatal abstinence syndrome (NAS) is a withdrawal syndrome of infants, caused by the cessation of the administration of licit or illicit drugs. Tolerance, dependence, and withdrawal may occur as a result of repeated administration of drugs or even after short-term high dose use -- for example during mechanical ventilation in intensive care units. There are two types of NAS: prenatal and postnatal. Prenatal NAS is caused by discontinuation of drugs taken by the pregnant mother, while postnatal NAS is caused by discontinuation of drugs directly to the infant.[1][2]
The drugs involved may be for example opioids, selective serotonin reuptake inhibitors (SSRIs), alcohol and benzodiazepines.[1][3] Neonatal abstinence syndrome does not happen in prenatal cocaine exposure (with babies exposed to cocaine in utero) in the sense that such symptoms are difficult to separate in the context of other factors such as prematurity or prenatal exposure to other drugs.[4]
When pharmacological treatment of opiate withdrawal in neonates is deemed necessary, opiates are the treatment of choice, which are slowly tapered down to wean the neonate off opiates.[5] Phenobarbitol is sometimes used as an alternative but is less effective in suppressing seizures; however, phenobarbitol is superior to diazepam for neonatal opiate withdrawal symptoms. In the case of sedative-hypnotic neonatal withdrawal, phenobarbitol is the treatment of choice.[6][7] Clonidine is an emerging add-on therapy.[8] Buprenorphine is under development as an alternative to morphine or methadone as initial therapy. [9]
A 2012 study from the University of Michigan and the University of Pittsburgh published in the Journal of the American Medical Association analyzed information on 7.4 million discharges from 4,121 hospitals in 44 states, to measure trends and costs associated with NAS over the past decade. The study indicated that between 2000 and 2009, the number of mothers using opiates increased from 1.19 to 5.63 per 1,000 hospital births per year. Newborns with NAS were 19% more likely than all other hospital births to have low birthweight and 30% more like to have respiratory complications. Between 2000 and 2009, total hospital charges for NAS cases, adjusted for inflation, are estimated to have increased from $190 million to $720 million.[10][11]
References[edit]
- ^ a b emedicine.com - Neonatal Abstinence Syndrome Author: Jaques Belik, MD
- ^ Hall, RW.; Boyle, E.; Young, T. (Oct 2007). "Do ventilated neonates require pain management?". Semin Perinatol 31 (5): 289–97. doi:10.1053/j.semperi.2007.07.002. PMID 17905183.
- ^ Iqbal MM, Sobhan T, Ryals T (January 2002). "Effects of commonly used benzodiazepines on the fetus, the neonate, and the nursing infant". Psychiatric Services 53 (1): 39–49. doi:10.1176/appi.ps.53.1.39. PMID 11773648.
- ^ Mercer, J (2009). "Claim 9: "Crack babies" can't be cured and will always have serious problems". Child Development: Myths and Misunderstandings. Thousand Oaks, Calif: Sage Publications, Inc. pp. 62–64. ISBN 1-4129-5646-3.
- ^ http://pediatrics.aappublications.org/content/129/2/e540.short
- ^ Osborn, DA.; Jeffery, HE.; Cole, M. (2010). "Opiate treatment for opiate withdrawal in newborn infants.". Cochrane Database Syst Rev (3): CD002059. doi:10.1002/14651858.CD002059.pub3. PMID 20927730.
- ^ Osborn, DA.; Jeffery, HE.; Cole, MJ. (2010). "Sedatives for opiate withdrawal in newborn infants.". Cochrane Database Syst Rev (3): CD002053. doi:10.1002/14651858.CD002053.pub3. PMID 20927729.
- ^ Kraft WK, van den Anker JN. Pharmacologic Management of the Opioid Neonatal Abstinence Syndrome. Pediatric Clinics of North America. 2012; 59(5):1147-65 [PMID: 23036249] http://jdc.jefferson.edu/petfp/39
- ^ Kraft WK, Dysart K, Greenspan J, Gibson E, Kaltenbach K, Ehrlich M. Revised Dose Schema of Sublingual Buprenorphine in the Treatment of the Neonatal Opioid Abstinence Syndrome. Addiction. 2011; 106(3):574-80 [PMID: 20925688]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022999/
- ^ "Neonatal Abstinence Syndrome and Associated Health Care Expenditures: United States, 2000-2009". JournalistsResource.org, retrieved May 15, 2012
- ^ Patrick, Stephen W.; Schumacher, Robert E.; Benneyworth, Brian D. (2012). "Neonatal Abstinence Syndrome and Associated Health Care Expenditures: United States, 2000-2009". Journal of the American Medical Association.
|
Certain conditions originating in the perinatal period / fetal disease (P, 760–779)
|
|
Maternal factors and
complications of pregnancy,
labour and delivery |
placenta: Placenta praevia · Placental insufficiency · Twin-to-twin transfusion syndrome
chorion/amnion: Chorioamnionitis
umbilical cord: Umbilical cord prolapse · Nuchal cord · Single umbilical artery
|
|
Length of gestation
and fetal growth |
Small for gestational age/Large for gestational age · Preterm birth/Postmature birth · Intrauterine growth restriction
|
|
| Birth trauma |
scalp (Cephalhematoma, Chignon, Caput succedaneum, Subgaleal hemorrhage) · Brachial plexus lesion (Erb's palsy, Klumpke paralysis)
|
|
| By system |
|
Respiratory
|
Intrauterine hypoxia · Infant respiratory distress syndrome · Transient tachypnea of the newborn · Meconium aspiration syndrome · pleural disease (Pneumothorax, Pneumomediastinum) · Wilson-Mikity syndrome · Bronchopulmonary dysplasia
|
|
|
Cardiovascular
|
Pneumopericardium · Persistent fetal circulation
|
|
|
Haemorrhagic and
hematologic disease
|
Vitamin K deficiency (Haemorrhagic disease of the newborn)
HDN (ABO • Anti-Kell • Rh c • Rh D • Rh E) · Hydrops fetalis · Hyperbilirubinemia (Kernicterus, Neonatal jaundice)
Velamentous cord insertion
Intraventricular hemorrhage (Germinal matrix hemorrhage)
Anemia of prematurity
|
|
|
Digestive
|
Ileus · Necrotizing enterocolitis · Meconium peritonitis
|
|
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Integument and
temperature regulation
|
Erythema toxicum · Sclerema neonatorum
|
|
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Nervous system
|
Periventricular leukomalacia
|
|
|
Musculoskeletal
|
Gray baby syndrome · muscle tone (Congenital hypertonia, Congenital hypotonia)
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|
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| Infectious |
Perinatal infection (Congenital rubella syndrome, Neonatal herpes simplex) · Omphalitis · Neonatal sepsis (Group B streptococcal infection) · Neonatal conjunctivitis
|
|
| Other |
Perinatal mortality (Stillbirth, Infant mortality) · Neonatal withdrawal
|
|
|
|
|
Neonatal Jaundice
UpToDate Contents
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English Journal
- Maternal and neonatal outcomes of Hepatitis C positive women attending a midwifery led drug and alcohol service: A West Australian perspective.
- O'Connor A1, Lewis L2, McLaurin R3, Barnett L4.
- Midwifery.Midwifery.2015 Aug;31(8):793-7. doi: 10.1016/j.midw.2015.04.007. Epub 2015 Apr 20.
- BACKGROUND: the Women and Newborn Drug and Alcohol Service (WANDAS) is a specialist, midwifery-led service providing pregnancy care to women dealing with alcohol and other drug (AOD) use, at the sole tertiary maternity hospital in Western Australia.AIM: to assess the antenatal, intrapartum and neona
- PMID 25957760
- Genetic Determinants of Fetal Opiate Exposure and Risk of Neonatal Abstinence Syndrome: Knowledge Deficits and Prospects for Future Research.
- Lewis T1,2, Dinh J1, Leeder JS1.
- Clinical pharmacology and therapeutics.Clin Pharmacol Ther.2015 Jun 9. doi: 10.1002/cpt.159. [Epub ahead of print]
- PMID 26058918
- [Methods in Neonatal Abstinence Syndrome (NAS): Results of a Nationwide Survey in Austria].
- Bauchinger S1, Sapetschnig I2, Danda M2, Sommer C2, Resch B2, Urlesberger B2, Raith W2.
- Zeitschrift fur Geburtshilfe und Neonatologie.Z Geburtshilfe Neonatol.2015 Jun 3. [Epub ahead of print]
- Background: Neonatal abstinence syndrome (NAS) occurs in neonates whose mothers have taken addictive drugs or were under substitution therapy during pregnancy. Incidence numbers of NAS are on the rise globally, even in Austria NAS is not rare anymore. The aim of our survey was to reveal the status q
- PMID 26039498
Japanese Journal
- Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants
Related Links
- Neonatal abstinence syndrome (NAS) is a group of problems that occur in a newborn who was exposed to addictive opiate drugs while in the mother’s womb.Causes Neonatal abstinence syndrome occurs because a pregnant woman ...
- Neonatal abstinence syndrome (NAS) is a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother’s womb. Two major types of NAS are recognized: NAS ...
Related Pictures
★リンクテーブル★
[★]
- 英
- neonatal abstinence syndrome
[★]
- 関
- neonatal period、neonatally、neonate、newborn、newborn animal、newborn infant
[★]
- 関
- disengage、withdrawal
[★]