negative inotropic effect

WordNet

1. reckoned in a direction opposite to that regarded as positive; "negative interest rates"
2. a piece of photographic film showing an image with light and shade or colors reversed
3. a reply of denial; "he answered in the negative"
4. not indicating the presence of microorganisms or disease or a specific condition; "the HIV test was negative" (同)disconfirming
5. having a negative charge; "electrons are negative" (同)electronegative, negatively charged
6. characterized by or displaying negation or denial or opposition or resistance; having no positive features; "a negative outlook on life"; "a colorless negative personality"; "a negative evaluation"; "a negative reaction to an advertising campaign"
7. expressing or consisting of a negation or refusal or denial
8. having the quality of something harmful or unpleasant; "ran a negative campaign"; "delinquents retarded by their negative outlook on life"
9. less than zero; "a negative number"
10. act so as to bring into existence; "effect a change"
11. a symptom caused by an illness or a drug; "the effects of sleep loss"; "the effect of the anesthetic"
12. (of a law) having legal validity; "the law is still in effect" (同)force
13. the central meaning or theme of a speech or literary work (同)essence, burden, core, gist
14. an impression (especially one that is artificial or contrived); "he just did it for effect"
15. produce; "The scientists set up a shock wave" (同)effectuate, set_up
16. property of a personal character that is portable but not used in business; "she left some of her personal effects in the house"; "I watched over their effects until they returned" (同)personal_effects

PrepTutorEJDIC

1. 『否定の』,反対の / 『消極的な』,控えめの / 陰電気の;(数値が)負の,マイナスの(minus);(写真が)陰画の,ネガの;(医学検査結果が)陰性の / 『否定』,拒否,「いやだ」と言うこと / 否定語[句] / 《the~》(特に討論会の)反対者側,反対派 / (電気分解に用いる)陰極板 / (数値の)負数 / (写真の)陰画,ネガ / 《しばしば受動態に用いて》…‘に'反対投票をする / =negate
2. 〈C〉〈U〉『結果』 / 〈C〉〈U〉(…への)『効果』,効きめ,影響《+『on』(『upon』)+『名』》 / 〈C〉(色・音・形などの)印象,感銘 / 《複数形で》品物;身の回り品;動産,財産 / (結果として)…‘を'『もたらす』;〈目的など〉‘を'果たす,遂行する

UpToDate Contents

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• 1. 収縮能障害による心不全における強心剤 inotropic agents in heart failure due to systolic dysfunction
• 2. 乳児および小児における心不全のマネージメント management of heart failure in infants and children
• 3. 昇圧剤および強心剤の使用 use of vasopressors and inotropes
• 4. 成人における重症敗血症および敗血症性ショックの評価およびマネージメント evaluation and management of severe sepsis and septic shock in adults
• 5. 新生児における細菌性髄膜炎：治療および転帰 bacterial meningitis in the neonate treatment and outcome

English Journal

• A Comparative Summary on Antioxidant-like Actions of Timolol with Other Antioxidants in Diabetic Cardiomyopathy.

• Turan B1.
• Current drug delivery.Curr Drug Deliv.2015 Nov 22. [Epub ahead of print]
• Cellular signaling associated with cardiac β-adrenergic receptors (β-AR) is composed of coupled mechanism among β1-/β2-AR and Gs proteins with contribution of constitutive β3-AR coupling to Gi proteins. However, downregulation of β-ARs in the heart under pathological conditions are mediated wi
• PMID 26593438

• The soluble guanylate cyclase stimulator riociguat and the soluble guanylate cyclase activator cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats.

• Reinke Y1, Gross S1, Eckerle LG2, Hertrich I2, Busch M2, Busch R1, Riad A1, Rauch BH3, Stasch JP4, Dörr M1, Felix SB5.
• European journal of pharmacology.Eur J Pharmacol.2015 Nov 15;767:1-9. doi: 10.1016/j.ejphar.2015.09.022. Epub 2015 Sep 25.
• In cardiovascular diseases, reduced responsiveness of soluble guanylate cyclase (sGC) to nitric oxide (NO) upon long-term application has led to the development of NO-independent sGC stimulators (heme-dependent) and sGC activators (heme-independent). Any direct inotropic or lusitropic effects of the
• PMID 26407652

• Effects of Ticagrelor on Ionic Currents and Contractility in Rat Ventricular Myocytes.

• Kucuk M1, Celen MC2, Yamasan BE2, Olgar Y2, Ozdemir S3.
• Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy.Cardiovasc Drugs Ther.2015 Oct;29(5):419-24. doi: 10.1007/s10557-015-6617-2.
• PURPOSE: Antiplatelet therapy has been widely used for management of patients with ischaemic heart diseases or thrombotic events. Experimental studies have shown that ticlopidine and clopidogrel decreased L-type Ca(2+) currents (ICaL), altered action potential (AP) duration and thence exerted negati
• PMID 26410045

Japanese Journal

• Influence of Acidosis on Cardiotonic Effects of Colforsin and Epinephrine: A Dose-Response Study

• Hagiya Keiichi,Takahashi Hiroshi,Isaka Yumi,Inomata Shinichi,Tanaka Makoto
• Journal of cardiothoracic and vascular anesthesia 27(5), 925-932, 2013-10
• … ObjectiveAcidosis produces a negative inotropic effect on cardiac muscle against which catecholamines and phosphodiesterase III inhibitors have limited therapeutic effects. …
• NAID 120005345618

• Effects of Landiolol Hydrochloride on Intractable Tachyarrhythmia After Pediatric Cardiac Surgery

• Tokunaga Chiho,Hiramatsu Yuji,Kanemoto Shinya,Takahashi-Igari Miho,Abe Masakazu,Horigome Hitoshi,Sakakibara Yuzuru
• The annals of thoracic surgery 95(5), 1685-1688, 2013-05
• … BackgroundWhile β-blockers can be effective in controlling tachyarrhythmias after pediatric cardiac surgery, a negative inotropic influence sometimes complicates their use. … The drug has higher β1:β2 selectivity ratio and a less negative inotropic effect. … The desired negative chronotropic effect was achieved without significant hemodynamic compromise. …
• NAID 120005296346

Related Links

• Negative inotropic effect of somatostatin in guinea-pig atrial fibres.

The effect of somatostatin (SS, 1 X 10(-7) M-5 X 10(-6) M) was studied on the electrical and mechanical properties of isolated atria of the guinea-pig. On spontaneously beating right atria, SS produced a dose-dependent negative ...

• Negative Inotropic And Physiological Effect Biology Essay

Negative inotropic effect was observed with the use of mBzR ligands, i.e. 4’-Cl-DZP, in various models including papillary muscle from right and ... ... Negative Inotropic And Physiological Effect Biology Essay Negative inotropic effect ...

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★リンクテーブル★

関連記事	「effect」「negative」「inotropic」「effected」

「effect」

　　[★]

• n.

• 結果。遂行、成就。
• 効果。効力。効き目、効能、影響。
• [美術・芸術]色彩、形の配合、光景、趣き、印象。外観、見え、体裁
• 趣旨、意図。本質、基本的意味

• vt.

• (変化などを)もたらす。(目的・計画など)果たす、遂げる。実施/施行する

関

act, action, affect, efficacy, impact, impinge, indication, influence, potency, effected

　 　 　 　 　 　 　

「negative」

　　[★]

• adj.

• 陰性の、負の、ネガティブな、否定的な

関

cryptic、negatively、negativity

　 　 　 　 　 　 　 　 　 　

「inotropic」

　　[★]

• adj.

• (生理)(薬が)(特に心臓の)筋肉の収縮に影響を与える、変力の、変力性の

「effected」

　　[★]

• adj.

• 結果として生じる

関

effect