negative inotropic effect

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英文文献

  • A Comparative Summary on Antioxidant-like Actions of Timolol with Other Antioxidants in Diabetic Cardiomyopathy.
  • Turan B1.
  • Current drug delivery.Curr Drug Deliv.2015 Nov 22. [Epub ahead of print]
  • Cellular signaling associated with cardiac β-adrenergic receptors (β-AR) is composed of coupled mechanism among β1-/β2-AR and Gs proteins with contribution of constitutive β3-AR coupling to Gi proteins. However, downregulation of β-ARs in the heart under pathological conditions are mediated wi
  • PMID 26593438
  • The soluble guanylate cyclase stimulator riociguat and the soluble guanylate cyclase activator cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats.
  • Reinke Y1, Gross S1, Eckerle LG2, Hertrich I2, Busch M2, Busch R1, Riad A1, Rauch BH3, Stasch JP4, Dörr M1, Felix SB5.
  • European journal of pharmacology.Eur J Pharmacol.2015 Nov 15;767:1-9. doi: 10.1016/j.ejphar.2015.09.022. Epub 2015 Sep 25.
  • In cardiovascular diseases, reduced responsiveness of soluble guanylate cyclase (sGC) to nitric oxide (NO) upon long-term application has led to the development of NO-independent sGC stimulators (heme-dependent) and sGC activators (heme-independent). Any direct inotropic or lusitropic effects of the
  • PMID 26407652
  • Effects of Ticagrelor on Ionic Currents and Contractility in Rat Ventricular Myocytes.
  • Kucuk M1, Celen MC2, Yamasan BE2, Olgar Y2, Ozdemir S3.
  • Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy.Cardiovasc Drugs Ther.2015 Oct;29(5):419-24. doi: 10.1007/s10557-015-6617-2.
  • PURPOSE: Antiplatelet therapy has been widely used for management of patients with ischaemic heart diseases or thrombotic events. Experimental studies have shown that ticlopidine and clopidogrel decreased L-type Ca(2+) currents (ICaL), altered action potential (AP) duration and thence exerted negati
  • PMID 26410045

和文文献

  • Influence of Acidosis on Cardiotonic Effects of Colforsin and Epinephrine: A Dose-Response Study
  • Hagiya Keiichi,Takahashi Hiroshi,Isaka Yumi,Inomata Shinichi,Tanaka Makoto
  • Journal of cardiothoracic and vascular anesthesia 27(5), 925-932, 2013-10
  • … ObjectiveAcidosis produces a negative inotropic effect on cardiac muscle against which catecholamines and phosphodiesterase III inhibitors have limited therapeutic effects. …
  • NAID 120005345618
  • Effects of Landiolol Hydrochloride on Intractable Tachyarrhythmia After Pediatric Cardiac Surgery
  • Tokunaga Chiho,Hiramatsu Yuji,Kanemoto Shinya,Takahashi-Igari Miho,Abe Masakazu,Horigome Hitoshi,Sakakibara Yuzuru
  • The annals of thoracic surgery 95(5), 1685-1688, 2013-05
  • … BackgroundWhile β-blockers can be effective in controlling tachyarrhythmias after pediatric cardiac surgery, a negative inotropic influence sometimes complicates their use. … The drug has higher β1:β2 selectivity ratio and a less negative inotropic effect. … The desired negative chronotropic effect was achieved without significant hemodynamic compromise. …
  • NAID 120005296346

関連リンク

The effect of somatostatin (SS, 1 X 10(-7) M-5 X 10(-6) M) was studied on the electrical and mechanical properties of isolated atria of the guinea-pig. On spontaneously beating right atria, SS produced a dose-dependent negative ...
Negative inotropic effect was observed with the use of mBzR ligands, i.e. 4’-Cl-DZP, in various models including papillary muscle from right and ... ... Negative Inotropic And Physiological Effect Biology Essay Negative inotropic effect ...

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image negative_inotropic_cardiac_function doc2doc forums - Doctors Community, Forums effects of positive inotropic effect negative inotropic effects by binding viahemodynamics : 네이버 블로그Can be a negative inotropic effect


★リンクテーブル★
関連記事negative」「effect」「effects」「inotropic」「effected

negative」

  [★]

  • adj.
  • 陰性の、負の、ネガティブな、否定的な
crypticnegativelynegativity

WordNet   license wordnet

「reckoned in a direction opposite to that regarded as positive; "negative interest rates"」

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「a piece of photographic film showing an image with light and shade or colors reversed」

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「a reply of denial; "he answered in the negative"」

PrepTutorEJDIC   license prepejdic

「『否定の』,反対の / 『消極的な』,控えめの / 陰電気の;(数値が)負の,マイナスの(minus);(写真が)陰画の,ネガの;(医学検査結果が)陰性の / 『否定』,拒否,「いやだ」と言うこと / 否定語[句] / 《the~》(特に討論会の)反対者側,反対派 / (電気分解に用いる)陰極板 / (数値の)負数 / (写真の)陰画,ネガ / 《しばしば受動態に用いて》…‘に'反対投票をする / =negate」

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「not indicating the presence of microorganisms or disease or a specific condition; "the HIV test was negative"」
disconfirming

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「having a negative charge; "electrons are negative"」
electronegative, negatively charged

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「characterized by or displaying negation or denial or opposition or resistance; having no positive features; "a negative outlook on life"; "a colorless negative personality"; "a negative evaluation"; "a negative reaction to an advertising campaign"」

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「expressing or consisting of a negation or refusal or denial」

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「having the quality of something harmful or unpleasant; "ran a negative campaign"; "delinquents retarded by their negative outlook on life"」

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「less than zero; "a negative number"」


effect」

  [★]

  • n.
  • vt.
  • (変化などを)もたらす。(目的・計画など)果たす、遂げる。実施/施行する
act, action, affect, efficacy, impact, impinge, indication, influence, potency, effected

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「act so as to bring into existence; "effect a change"」

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「a symptom caused by an illness or a drug; "the effects of sleep loss"; "the effect of the anesthetic"」

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「(of a law) having legal validity; "the law is still in effect"」
force

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「the central meaning or theme of a speech or literary work」
essence, burden, core, gist

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「an impression (especially one that is artificial or contrived); "he just did it for effect"」

PrepTutorEJDIC   license prepejdic

「〈C〉〈U〉『結果』 / 〈C〉〈U〉(…への)『効果』,効きめ,影響《+『on』(『upon』)+『名』》 / 〈C〉(色・音・形などの)印象,感銘 / 《複数形で》品物;身の回り品;動産,財産 / (結果として)…‘を'『もたらす』;〈目的など〉‘を'果たす,遂行する」

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「produce; "The scientists set up a shock wave"」
effectuate, set up

effects」

  [★]

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「property of a personal character that is portable but not used in business; "she left some of her personal effects in the house"; "I watched over their effects until they returned"」
personal effects


inotropic」

  [★]

  • adj.
  • (生理)(薬が)(特に心臓の)筋肉の収縮に影響を与える、変力の、変力性の


effected」

  [★]

  • adj.
  • 結果として生じる
effect




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