WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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1. 駆出率が保たれた心不全の臨床症状および診断 clinical manifestations and diagnosis of heart failure with preserved ejection fraction
2. 駆出率が保たれた心不全の治療および予後 treatment and prognosis of heart failure with preserved ejection fraction
3. 駆出率を保持している心不全の病態生理 pathophysiology of heart failure with preserved ejection fraction
4. 心不全の疫学および原因 epidemiology and causes of heart failure
5. 心筋症の定義および分類 definition and classification of the cardiomyopathies

Activated immune-inflammatory pathways are associated with long-standing depressive symptoms: Evidence from gene-set enrichment analyses in the Young Finns Study.

Elovainio M1, Taipale T2, Seppälä I2, Mononen N2, Raitoharju E2, Jokela M3, Pulkki-Råback L4, Illig T5, Waldenberger M6, Hakulinen C3, Hintsa T3, Kivimäki M7, Kähönen M8, Keltikangas-Järvinen L3, Raitakari O9, Lehtimäki T2.
Journal of psychiatric research.J Psychiatr Res.2015 Dec;71:120-5. doi: 10.1016/j.jpsychires.2015.09.017. Epub 2015 Oct 22.
We used genome wide expression (GWE) data of circulating blood cells and pathway analysis to investigate the inflammatory and other molecular pathways that may be associated with long-standing depressive symptoms. Participants were 607 women and 316 men (mean age 42 years) from the Young Finns Study
PMID 26473696

A Case of Wiedemann-Steiner Syndrome Associated with a 46,XY Disorder of Sexual Development and Gonadal Dysgenesis.

Calvel P1, Kusz-Zamelczyk K, Makrythanasis P, Janecki D, Borel C, Conne B, Vannier A, Béna F, Gimelli S, Fichna P, Antonarakis SE, Nef S, Jaruzelska J.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation.Sex Dev.2015 Nov 7. [Epub ahead of print]
We report the case of a female patient suffering from a 46,XY disorder of sexual development (DSD) with complete gonadal dysgenesis and Wiedemann-Steiner Syndrome (WDSTS). The coexistence of these 2 conditions has not yet been reported. Using whole exome sequencing and comparative genome hybridizati
PMID 26544196

DICER Regulates the Formation and Maintenance of Cell-Cell Junctions in the Mouse Seminiferous Epithelium.

Korhonen HM, Yadav RP, Da Ros M, Chalmel F, Zimmermann C, Toppari J, Nef S, Kotaja N.
Biology of reproduction.Biol Reprod.2015 Oct 28. pii: biolreprod.115.131938. [Epub ahead of print]
The endonuclease DICER that processes microRNAs (miRNAs) and small interfering RNAs (siRNAs) is essential for normal spermatogenesis and male fertility. We previously showed that the deletion of Dicer1 gene in postnatal spermatogonia in mice using Ngn3 promoter-driven Cre expression caused severe de
PMID 26510868