nedocromil sodium

Nedocromil
Systematic (IUPAC) name
	9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Clinical data
Trade names	Alocril
AHFS/Drugs.com	monograph
MedlinePlus	a601243
Pregnancy cat.	?
Legal status	POM (UK) ℞-only (US)
Routes	Inhalation and eye drops
Pharmacokinetic data
Protein binding	89%
Metabolism	not metabolized
Half-life	~3.3 hours
Excretion	excreted unchanged
Identifiers
CAS number	69049-73-6
ATC code	R01AC07 R03BC03, S01GX04
PubChem	CID 50294
DrugBank	DB00716
ChemSpider	45608
UNII	0B535E0BN0
KEGG	D05129
ChEBI	CHEBI:7492
ChEMBL	CHEMBL746
Chemical data
Formula	C19H17NO7
Mol. mass	371.341 g/mol
	SMILES O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC;
	InChI InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26) ; Key:RQTOOFIXOKYGAN-UHFFFAOYSA-N ;
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同: Tilade

WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

PrepTutorEJDIC

ソジウム,ナトリウム(金属元素;化学記号はNa)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/19 11:30:05」(JST)

wiki en

[Wiki en表示]

Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade (although its effects in this form are far less than those in albuterol or other well-known inhaler medications) and as an eye drop under the brand name Alocril. Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.^[1]

Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.^[2]

References

^ "Nedocromil eye drops" (in English). 2007-02-02. http://www.patient.co.uk/showdoc/30003772. Retrieved 2009-08-04.
^ http://www.fda.gov/downloads/Drugs/DrugSafety/DrugShortages/ucm089433.pdf

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1. 喘息の治療におけるクロモン（クロモグリク酸）の使用 the use of chromones cromoglycates in the treatment of asthma
2. 12歳未満の小児における慢性喘息：持続性喘息の治療およびコントロール薬 asthma in children younger than 12 years treatment of persistent asthma with controller medications
3. 運動誘発性気管支収縮 exercise induced bronchoconstriction
4. 妊娠中の喘息のマネージメント management of asthma during pregnancy
5. 春季カタル vernal keratoconjunctivitis

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Estrogen inhibits mast cell chymase release to prevent pressure overload-induced adverse cardiac remodeling.

Li J1, Jubair S1, Janicki JS2.
Hypertension.Hypertension.2015 Feb;65(2):328-34. doi: 10.1161/HYPERTENSIONAHA.114.04238. Epub 2014 Nov 17.
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Wu K1, Gamazon ER, Im HK, Geeleher P, White SR, Solway J, Clemmer GL, Weiss ST, Tantisira KG, Cox NJ, Ratain MJ, Huang RS.
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Howrylak JA, Fuhlbrigge AL, Strunk RC, Zeiger RS, Weiss ST, Raby BA; Childhood Asthma Management Program Research Group.
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