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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/18 02:58:38」(JST)

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Nebacumab is a human monoclonal antibody developed for the treatment of sepsis.^[1] It has been withdrawn in 1993 because it failed to reduce mortality in clinical trials.^[2]

References

^ Derkx, B.; Wittes, J.; McCloskey, R. (1999). "Randomized, Placebo‐Controlled Trial of HA‐1A, a Human Monoclonal Antibody to Endotoxin, in Children with Meningococcal Septic Shock". Clinical Infectious Diseases 28 (4): 770–726. doi:10.1086/515184. PMID 10825037.
^ WHO: Consolidated List of Products

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English Journal

The birth pangs of monoclonal antibody therapeutics: the failure and legacy of Centoxin.

Marks L1.
mAbs.MAbs.2012 May-Jun;4(3):403-12. doi: 10.4161/mabs.19909. Epub 2012 Apr 26.
This paper examines the development and termination of nebacumab (Centoxin®), a human IgM monoclonal antibody (mAb) drug frequently cited as one of the notable failures of the early biopharmaceutical industry. The non-approval of Centoxin in the United States in 1992 generated major concerns at the
PMID 22531443

Marketed therapeutic antibodies compendium.

Reichert JM1.
mAbs.MAbs.2012 May-Jun;4(3):413-5. doi: 10.4161/mabs.19931. Epub 2012 Apr 26.
Therapeutic monoclonal antibodies (mAbs) are currently being approved for marketing in Europe and the United States, as well as other countries, on a regular basis. As more mAbs become available to physicians and patients, keeping track of the number, types, production cell lines, antigenic targets,
PMID 22531442

Biotechnology and clinical trials.

Siegel JP1.
The Journal of infectious diseases.J Infect Dis.2002 Feb 15;185 Suppl 1:S52-7.
Not surprisingly, clinical trials have been critically important to developments in the field of biotechnology. Perhaps less expectedly, the clinical trials of biotechnology products have been critically important to recent developments in the field of clinical trials design, conduct, and analysis.
PMID 11865440

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「mab」

Nebacumab
Monoclonal antibody
Type	Whole antibody
Source	Human
Target	endotoxin
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	138661-01-5
ATC code	J06BC01
KEGG	D05126
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