natural killer cells

出典: meddic

ナチュラルキラー細胞

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/12 09:22:53」(JST)

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英文文献

  • CD56(bright) natural killer cells and response to daclizumab HYP in relapsing-remitting MS.
  • Elkins J1, Sheridan J1, Amaravadi L1, Riester K1, Selmaj K1, Bielekova B1, Parr E1, Giovannoni G1.
  • Neurology® neuroimmunology & neuroinflammation.Neurol Neuroimmunol Neuroinflamm.2015 Jan 22;2(2):e65. doi: 10.1212/NXI.0000000000000065. eCollection 2015.
  • OBJECTIVE: To assess the relationship between CD56(bright) natural killer (NK) cells and multiple sclerosis (MS) disease activity in patients with relapsing-remitting MS treated with daclizumab high-yield process (DAC HYP).METHODS: Data were from patients enrolled in a 52-week randomized, double-bli
  • PMID 25635261
  • The role of IL-21 in immunity and cancer.
  • Davis MR1, Zhu Z2, Hansen DM1, Bai Q2, Fang Y3.
  • Cancer letters.Cancer Lett.2015 Mar 28;358(2):107-14. doi: 10.1016/j.canlet.2014.12.047. Epub 2015 Jan 6.
  • Interleukin-21 (IL-21), produced predominantly by CD4+ T cells and natural killer T (NKT) cells, is a newly discovered member of the common γ-chain family of cytokines. It has been implicated in many immunological processes and has been linked to autoimmune diseases, allergies and other inflammator
  • PMID 25575696
  • The role of the maternal immune system in the regulation of human birthweight.
  • Moffett A1, Hiby SE2, Sharkey AM2.
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences.Philos Trans R Soc Lond B Biol Sci.2015 Mar 5;370(1663). pii: 20140071.
  • Human birthweight is subject to stabilizing selection. Large babies are at risk of obstetric complications such as obstructed labour, which endangers both mother and child. Small babies are also at risk with reduced survival. Fetal growth requires remodelling of maternal spiral arteries to provide a
  • PMID 25602075

和文文献

  • メタボリックシンドロームとNKT細胞 (特集 自然T細胞の機能をめぐって)
  • 近藤 泰介,久和 茂
  • 臨床免疫・アレルギー科 61(3), 266-273, 2014-03
  • NAID 40020017434
  • Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection
  • Nabekura Tsukasa,Kanaya Minoru,Shibuya Akira,Fu Guo,Gascoigne Nicholas R.J.,Lanier Lewis L.,渋谷 彰
  • Immunity 40(2), 225-234, 2014-02
  • … Recent studies demonstrate that natural killer (NK) cells have adaptive immune features. … Here, we investigated the role of the costimulatory molecule DNAM-1 in the differentiation of NK cells in a mouse model of cytomegalovirus (MCMV) infection. … Antibody blockade of DNAM-1 suppressed the expansion of MCMV-specific Ly49H+ cells during viral infection and inhibited the generation of memory NK cells. …
  • NAID 120005425984
  • Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo.
  • Cui Guangwei,Hara Takahiro,Simmons Szandor,Wagatsuma Keisuke,Abe Akifumi,Miyachi Hitoshi,Kitano Satsuki,Ishii Masaru,Tani-Ichi Shizue,Ikuta Koichi
  • Proceedings of the National Academy of Sciences of the United States of America, 2014-01-21
  • … 2014-01-21.IL-15 is a cytokine critical for development, maintenance, and response of T cells, natural killer (NK) cells, NK T cells, and dendritic cells. … However, the identity and distribution of IL-15-expressing cells in lymphoid organs are not well understood. …
  • NAID 120005367797

関連リンク

Natural killer cells (also known as NK cells, K cells, and killer cells) are a type of lymphocyte (a white blood cell) and a component of innate immune system. NK cells play a major role in the host-rejection of both tumours and virally ...
1. Blood. 2008 Aug 1;112(3):461-9. doi: 10.1182/blood-2007-09-077438. Human natural killer cells. Caligiuri MA(1). Author information: (1)The Ohio State University Comprehensive Cancer Center, The James Cancer ...

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★リンクテーブル★
先読みナチュラルキラー細胞
関連記事natural」「kill」「cell」「killer」「natural killer

ナチュラルキラー細胞」

  [★]

natural killer cell, NK cell
NK細胞
単球自然免疫LAK細胞ナチュラルキラー細胞活性natural killer


概念

  • 自然免疫
  • リンパ球の5-10%を占めるらしい。
Large granular lymphocytes(LGLs) or NK cells account for 5-10% of periphral blood plymphocytes.(HAR.2024)
  • 大型のアズール好性顆粒を有する(SMB.41)
  • 単球と共に自然免疫に関与
  • ウイルス感染細胞やガン細胞を傷害する細胞で、T細胞に特異的なマーカをもたずに直接標的細胞を攻撃する (人間の正常構造と機能 VIIA血管・免疫 p.29)
  • 抗体依存性細胞毒性(ADCC)
II型アレルギーにかかわる

分子細胞学的な定義

機能

自然免疫

ADCC

  • IgGのFc部を結合し、顆粒を放出する(IMM.96)

分子マーカー

~

  • CD8:IL-2に反応してNK細胞が増殖
  • CD57:多くの細胞表面で発現

ケモカイン

リガンド 作用 産生
IL-12 NK細胞活性化 INF-γ
IL-18 Th1分化促進
  • IL-12,IL-18により活性化され、IFN-γを産生
  • IL-2により活性化し、細胞障害能が高まる (SPU.65)

受容体

  • NIR
MHC class Iを認識して攻撃を抑制。MHC class Iが少ないと抑制が外れる(IMM.96)


natural」

  [★]

  • adj.
  • 自然な、天然の、当然の、もっともな
justifiablelogicalnativenaturallynatureproperreasonablereasonablyspontaneousspontaneously

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「related by blood; not adopted」

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「(craps) a first roll of 7 or 11 that immediately wins the stake」

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「a notation cancelling a previous sharp or flat」
cancel

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「someone regarded as certain to succeed; "he''s a natural for the job"」

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「being talented through inherited qualities; "a natural leader"; "a born musician"; "an innate talent"」
born, innate

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「unthinking; prompted by (or as if by) instinct; "a cat''s natural aversion to water"; "offering to help was as instinctive as breathing"」
instinctive

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「(used especially of commodities) being unprocessed or manufactured using only simple or minimal processes; "natural yogurt"; "natural produce"; "raw wool"; "raw sugar"; "bales of rude cotton"」
raw, rude

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「(of a musical note) being neither raised nor lowered by one chromatic semitone; "a natural scale"; "B natural"」

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「existing in or in conformity with nature or the observable world; neither supernatural nor magical; "a perfectly natural explanation"」

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「existing in or produced by nature; not artificial or imitation; "a natural pearl"; "natural gas"; "natural silk"; "natural blonde hair"; "a natural sweetener"; "natural fertilizers"」

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「functioning or occurring in a normal way; lacking abnormalities or deficiencies; "it''s the natural thing to happen"; "natural immunity"; "a grandparent''s natural affection for a grandchild"」

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「in accordance with nature; relating to or concerning nature; "a very natural development"; "our natural environment"; "natural science"; "natural resources"; "natural cliffs"; "natural phenomena"」

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「『自然のままの』,自然にある,自然が作る / 自然に関する / 『当然の』,あたりまえの / 『生まれつきの』(inborn) / 生き写しの,真に迫った / 気どらない,飾らない / (音階が)本位の / (音階の)本位音;本位記号 / 《単数形で》《話》(…の)生来の達人,(…に)最初からうってつけの人《+『for』(『as』)+『名』》」

kill」

  [★]

  • v.
killing

linux

option
9 KILL プロセスの強制終了
  • ex.
kill -9 process_id

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「overwhelm with hilarity, pleasure, or admiration; "The comedian was so funny, he was killing me!"」

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「cause to cease operating; "kill the engine"」

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「destroy a vitally essential quality of or in; "Eating artichokes kills the taste of all other foods"」

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「tire out completely; "The daily stress of her work is killing her"」

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「the destruction of an enemy plane or ship or tank or missile; "the pilot reported two kills during the mission"」

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「〈人・動物〉‘を'『殺す』,死亡させる / 〈植物〉‘を'枯らす / …‘を'だめにする,失わせる / 《話》…‘を'ひどく痛ませる(疲れさせる,不快にさせる) / 〈時間〉‘を'つぶす / 〈記事など〉‘を'没にする,握りつぶす / 人殺しをする / 殺すこと;(特に狩猟の)獲物をしとめること / (猟の)獲物」

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「mark for deletion, rub off, or erase; "kill these lines in the President''s speech"」
obliterate, wipe out

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「thwart the passage of; "kill a motion"; "he shot down the student''s proposal"」
shoot down, defeat, vote down, vote out

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「be fatal; "cigarettes kill"; "drunken driving kills"」

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「be the source of great pain for; "These new shoes are killing me!"」

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「cause the death of, without intention; "She was killed in the collision of three cars"」

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「cause to die; put to death, usually intentionally or knowingly; "This man killed several people when he tried to rob a bank"; "The farmer killed a pig for the holidays"」

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「deprive of life; "AIDS has killed thousands in Africa"」

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「hit with great force; "He killed the ball"」

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「hit with so much force as to make a return impossible, in racket games; "She killed the ball"」

cell」

  [★] 細胞

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「small room in which a monk or nun lives」
cubicle

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「a device that delivers an electric current as the result of a chemical reaction」
electric cell

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「a room where a prisoner is kept」
jail cell, prison cell

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「(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals」

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「any small compartment; "the cells of a honeycomb"」

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「a small unit serving as part of or as the nucleus of a larger political movement」
cadre

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「(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞」


killer」

  [★]

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「someone who causes the death of a person or animal」
slayer

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「a difficulty that is hard to deal with; "that exam was a real killer"」

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「殺人者;屠殺(とさつ)者;殺し屋」


natural killer」

  [★]




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