naloxone benzoylhydrazone

出典: meddic


UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • Binding of GTPgamma[35S] is regulated by GDP and receptor activation. Studies with the nociceptin/orphanin FQ receptor.
  • McDonald J1, Lambert DG.
  • British journal of pharmacology.Br J Pharmacol.2010 Mar;159(6):1286-93. doi: 10.1111/j.1476-5381.2009.00621.x. Epub 2010 Feb 10.
  • BACKGROUND AND PURPOSE: We have examined the effects of ligand efficacy and receptor density on the binding of guanosine 5'-[gamma-thio]triphosphate (GTPgammaS) and GDP to the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP)-coupled G-proteins. Experimental approach: In GTPgamma[(35)S] binding
  • PMID 20148892
  • The nociceptin system and hippocampal cognition in mice: a pharmacological and genetic analysis.
  • Kuzmin A1, Madjid N, Johansson B, Terenius L, Ogren SO.
  • Brain research.Brain Res.2009 Dec 11;1305 Suppl:S7-19. doi: 10.1016/j.brainres.2009.09.075. Epub 2009 Sep 25.
  • This study examines the effects of NOP agonists nociceptin/orphanin FQ (N/OFQ) and Ro 64-6198, NOP antagonists [Nphe(1)]N/OFQ(1-13)-NH(2) Nphe(1) and naloxone benzoylhydrazone (NalBzoH) on spatial memory in NMRI mice and pronociceptin (proNC) knockout (KO) mice using the water maze task. N/OFQ, admi
  • PMID 19782658

和文文献

  • Gastric Acid Secretion by Central Injection of Dynorphin A-(1-17), an Endogenous Ligand of κ-Opioid Receptor, in Urethane-Anesthetized Rats
  • , , [他], ,
  • The Japanese journal of pharmacology 87(1), 14-20, 2001-09-01
  • … The LV injection of naloxone benzoylhydrazone (a κ3-opioid receptor agonist, 100 μg) also stimulated the secretion in norbinaltorphimine-sensitive manner. …
  • NAID 130000078334
  • Characterization of Specific[^3H]Nociceptin Binding in Rat Brain and Spinal Cord
  • , ,
  • Biological & pharmaceutical bulletin 24(8), 902-905, 2001-08-01
  • … Nociceptin and its analogue, [Phe^1Ψ(CH_2-NH)-Gly^2]nociceptin(1-13)NH_2 were found to be potent inhibitors of[^3H]nociceptin binding to crude membranes from the brain and spinal cord, while opioid ligands such as naloxone-benzoylhydrazone, naltrindole and nor-binaltorphimine, exhibited an inhibitory effect only at high concentrations. …
  • NAID 110003638585

関連リンク

View and buy high purity Naloxone benzoylhydrazone from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... Biological Activity Mixed opioid receptor agonist/antagonist. Acts as a potent ...
Sigma-Aldrich offers Sigma-N165, Naloxone benzoylhydrazone for your research needs. Find product specific information including CAS, MSDS, protocols and references. ... Biochem/physiol Actions Agonist for κ 3 opioid ...

関連画像

 naloxone benzoylhydrazone (NBH) or withPeripheral effects of nociceptin on the  naloxone benzoylhydrazone (NBH) or withFigure 2 : Non-peptide nociceptin/orphanin Influence of naloxone benzoylhydrazone


★リンクテーブル★
リンク元オピオイド
関連記事naloxone

オピオイド」

  [★]

opioid
類麻薬
オピオイド受容体


作用

縮瞳

  • モルフィンと多くのμ,κアゴニストは瞳孔の縮小を引き起こす。これは瞳孔を支配する副交感神経の興奮による。μアゴニストを中毒量投与すると縮瞳し、pinpoints pupupilsはpathognomonicである。(GOO.559)

オピオイドとオピオイド類似物質の作用

GOO.552
Drugs  RECEPTOR TYPES
μ受容体 δ受容体 κ受容体
morphine +++  
methadone +++    
etorphine +++ +++ +++
levorphanol +++    
fentanyl +++    
sufentanil +++
DAMGO +++    
butorphanol P   +++
buprenorphine P   ーー
naloxone ーーー ーー
naltrexone ーーー ーーー
CTOP ーーー    
diprenorphine ーーー ーー ーーー
β-funaltrexamine ーーー ++
naloxonazine ーーー
nalorphine ーーー  
pentazocine P   ++
nalbuphine ーー   ++
naloxone benzoylhydrazone ーーー
bremazocine +++ ++ +++
ethylketocyclazocine P +++
U50,488     +++
U69,593     +++
spiradoline   +++
nor-Binaltorphimine ーーー
naltrindole ーーー
DPDPE   ++  
[[[[D-Ala2,Glu4]deltorphin]]   ++  
       
DSLET ++  
endogenous Peptides       
met-enkephalin ++ +++  
leu-enkephalin ++ +++  
β-endorphin +++ +++  
dynorphin A ++   +++
dynorphin B +++
α-neoendorphin +++
+アゴニスト ーアンタゴニスト P partial agonist

各鎮痛薬のオピオイド受容体への作用

         μ受容体 κ受容体
レミフェンタニル +++  ー
フェンタニル   +++  -
モルヒネ     +++  +
ペチジン     ++   +
トラマドール   +    -
ペンタゾシン   ー    ++
ブプレノルフィン P    ー
ナロキソン    ー    -



naloxone」

  [★] ナロキソン

WordNet   license wordnet

「a potent narcotic antagonist (trade name Narcan) especially effective with morphine」
Narcan




★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡