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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/01/07 15:18:36」(JST)

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  • A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice.
  • Bilbao A1, Robinson JE2, Heilig M3, Malanga CJ2, Spanagel R1, Sommer WH1, Thorsell A4.
  • Biological psychiatry.Biol Psychiatry.2015 May 15;77(10):850-8. doi: 10.1016/j.biopsych.2014.08.021. Epub 2014 Sep 8.
  • BACKGROUND: It has been proposed that therapeutic responses to naltrexone in alcoholism are moderated by variation at the mu-opioid receptor gene locus (OPRM1). This remains controversial because human results vary and no prospectively genotyped studies have been reported. We generated humanized mic
  • PMID 25442002
  • Nalmefene for Reducing Alcohol Consumption in People with Alcohol Dependence: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.
  • Stevenson M1, Pandor A, Stevens JW, Rawdin A, Rice P, Thompson J, Morgan MY.
  • PharmacoEconomics.Pharmacoeconomics.2015 Apr 8. [Epub ahead of print]
  • As part of its single technology appraisal process, the National Institute for Health and Care Excellence (NICE) invited the company (Lundbeck) marketing nalmefene (Selincro) to submit evidence of its clinical and cost effectiveness for reducing alcohol consumption in people with alcohol dependence.
  • PMID 25851485
  • Safety and tolerability of as-needed nalmefene in the treatment of alcohol dependence: results from the Phase III clinical programme.
  • van den Brink W1, Strang J, Gual A, Sørensen P, Jensen TJ, Mann K.
  • Expert opinion on drug safety.Expert Opin Drug Saf.2015 Apr;14(4):495-504. doi: 10.1517/14740338.2015.1011619. Epub 2015 Feb 4.
  • OBJECTIVE: To investigate safety and tolerability of nalmefene for reduction of alcohol consumption in alcohol-dependent patients.METHODS: Pooled data from three randomized, placebo-controlled studies (two 6-month; one 12-month) of 18 mg nalmefene (as-needed use) in alcohol-dependent patients lookin
  • PMID 25652768


  • Influence of Supercritical Antisolvent Micronization Parameters on Nalmefene HCl Powder Characteristics
  • Advanced powder technology : the international journal of the Society of Powder Technology, Japan 19(6), 523-540, 2008-11-01
  • NAID 10024018722
  • Application of a sensitive liquid chromatographic/tandem mass spectrometric method to pharmacokinetic study of nalmefene in humans
  • LI Ping,CHEN Xiaoyan,DAI Xiaojian,WEN Aidong,ZHANG Yifan,ZHONG Dafang
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 852(1), 479-484, 2007-06-01
  • NAID 10025802639


nal·me·fene / ˈnæl məˌfin / Show Spelled [nal-m uh-feen] Show IPA noun Pharmacology. a drug, C 21 H 25 NO 3, used in the treatment of dependence disorders, as alcoholism and narcotics addiction. Unabridged
The new drug for alcoholism, nalmefene is being touted as a cure for alcoholism. Is this alcoholism medicine really that effective? ... Alcoholism is a terrible condition for the sufferer and those who care about him or her. What makes ...
nalmefene /nal·me·fene/ (nal´mĕ-fēn″) an opioid antagonist, used as the hydrochloride salt in the treatment of opioid overdose and postoperative opioid depression. nalmefene [nal′mĕfēn′] an opioid antagonist, used as the hydrochloride ...


Selincro (Nalmefene)NalmefeneNalmefene, farmaco ” speranza ” nella Selincro (nalmefene) - Treatment for  , new anti-alcohol drug, nalmefene3e10fb0633c4bfb39636ef957397a284




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