Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/03 10:05:41」(JST)

wiki en

Naftidrofuryl (INN, also known as nafronyl or as the oxalate salt naftidrofuryl oxalate or nafronyl oxalate) is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic.^[1] It may also be a 5-HT₂ receptor antagonist. It is also licenced for the treatment of intermittent claudication due to peripheral arterial disease.

It is sold under the brand name Dusodril (Merck) and cerebromap for multiapex in middle east. It is also sold as Praxilene in the United Kingdom.^[2]

Historically, it has been used to treat sudden idiopathic hearing loss and acute tinnitus.^[3]

Naftidrofuryl may be effective for relieving the pain of muscle cramps.^[4]

References[edit source | edit]

^ Reynolds, J.E.F. (ed.) (1993). Martindale: The extra pharmacopoeia (30th edition ed.). London: Pharmaceutical Press. p. 1310. ISBN 0-85369-300-5.
^ http://www.patient.co.uk/medicine/naftidrofuryl
^ http://www.der-arzneimittelbrief.de/Jahrgang2004/Ausgabe12Seite89.htm
^ Katzberg HD, Khan AH, So YT (February 2010). "Assessment: Symptomatic treatment for muscle cramps (an evidence-based review): Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology". Neurology 74 (8): 691–6. doi:10.1212/WNL.0b013e3181d0ccca. PMID 20177124.

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 下肢末梢動脈疾患の症状を治療するための試験的治療 investigational therapies for treating symptoms of lower extremity peripheral artery disease
2. 跛行のマネージメント management of claudication
3. 夜間の足痙攣 nocturnal leg cramps
4. 骨壊死症（無血管性骨壊死症） osteonecrosis avascular necrosis of bone
5. 患者情報：末梢動脈疾患および跛行（詳細） peripheral artery disease and claudication beyond the basics

English Journal

Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor.

Hao J, Chen B, Yao Y, Hossain M, Nagatomo T, Yao H, Kong L, Sun H.SourceState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Tianjin State Key Lab Modern Chinese Med, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2012 May 15;22(10):3441-4. Epub 2012 Apr 1.
Naftidrofuryl oxalate (Praxilene®, 1) has been used for the treatment of intermittent claudication for more than 30years. It selectively blocks vascular and platelet 5-hydroxytryptamine 2 (5-HT(2)) receptors. This drug is marketed as a mixture of four stereoisomers, and so far there is no individua
PMID 22516281

Preventive aspects in peripheral artery disease.

Aggarwal S, Loomba RS, Arora R.Source3333 Green Bay Road, North Chicago, IL-60064, USA.
Therapeutic advances in cardiovascular disease.Ther Adv Cardiovasc Dis.2012 Apr;6(2):53-70. Epub 2012 Feb 15.
The prevalence of peripheral artery disease is steadily increasing and is associated with significant morbidity, including a significant percentage of amputations. Peripheral artery disease often goes undiagnosed, making its prevention increasingly important. Patients with peripheral arterial diseas
PMID 22337767

Japanese Journal

Assessment of Binding Affinity to 5-Hydroxytryptamine 2A (5-HT_<2A>) Receptor and Inverse Agonist Activity of Naftidrofuryl : Comparison With Those of Sarpogrelate

Aly Saida Abdel Regal,Hossain Murad,Bhuiyan Mohiuddin Ahmed [他],NAKAMURA Takashi,NAGATOMO Takafumi
Journal of pharmacological sciences 110(4), 445-450, 2009-08-20
… Naftidrofuryl is a peripheral vasodilator that has been clinically used in the treatment of intermittent claudication and dementia. … The purpose of the present study is to assess the binding affinity and functional potency of naftidrofuryl to the 5-HT2A receptor, to find out the inverse agonist activity of this compound at a constitutively active mutant of 5-HT2A receptor, and finally to compare the findings with those of sarpogrelate. …
NAID 10025738188

低酸素性致死に対するNaftidrofuryl Oxalateの延命作用

林潤一 [他],佐藤恭子,秋本孝行,佐藤秀昭,秦葭哉
日本薬理学雑誌 99(4), 247-254, 1992
… To analyze the effects of naftidrofuryl oxalate (LS-121) on the central nervous system exposed to critical hypoxia, survival duration was employed as a parameter of the protective effects of the drug against hypoxia-induced death. …
NAID 130000758774

Ischemia-Induced Changes in Brain Levels of Monoamines and Their Metabolites of Mice and Rats : Some Protective Effects of Naftidrofuryl

NAKAMUTA Hiromichi,MUGURUMA Keiko,KOIDA Masao,HIRAMATSU Yasuzo,OGAWA Yasunao
Journal of pharmacobio-dynamics 12(7), 429-436, 1989-07-00
… Employing two types of brain ischemic animal models, an attempt was made to evaluate the protective effect of naftidrofuryl as the normalizing effect on the ischemia-induced changes in the brain levels of monoamines and metabolites. … Pretreatment with naftidrofuryl oxalate (45 mg/kg, i.p.) was found to prevent the DA change, but the lower dose (15 mg/kg, i.p.) of the drug or any other drug tested individually (vinpocetine hydrochloride : 2 mg/kg, Ca hopantenate : 0.1 g/kg, citicoline : 0.1 g/kg, i.p.) had no such effect. …
NAID 110003663128

Related Pictures

Naftidrofuryl: Công dụng, liều dùng, tác dụng phụ • Hello Bacsi Naftidrofuryl; nafronyl The Fontaine Classification for chronic critical limb ischaemia a | Download Table Страница №73 Средства, влияющие на сердечно Tradename: NAFTIDROFURYL BIOGARAN 200 mg, comprimé pelliculé Praxilene Dosage & Drug Information | MIMS.com Indonesia

★リンクテーブル★

リンク元	「ナフチドロフリル」

「ナフチドロフリル」

Naftidrofuryl
Systematic (IUPAC) name
	(RS)-2-(diethylamino)ethyl 3-(1-naphthyl)-2-(tetrahydrofuran-2-ylmethyl)propanoate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Routes	Oral
Identifiers
CAS number	31329-57-4
ATC code	C04AX21
PubChem	CID 4417
ChemSpider	4264
UNII	42H8PQ0NMJ
Chemical data
Formula	C24H33NO3
Mol. mass	383.524 g/mol
	SMILES O=C(OCCN(CC)CC)C(Cc2c1ccccc1ccc2)CC3OCCC3;
	InChI InChI=1S/C24H33NO3/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3 ; Key:KBAFPSLPKGSANY-UHFFFAOYSA-N ;
(what is this?) (verify);

　　[★]

英: naftidrofuryl
関: ナフロニル nafronyl

末梢性血管弛緩薬;5-HT2遮断薬
日本では発売されていない。

参考

1. wiki en

http://en.wikipedia.org/wiki/Naftidrofuryl

[1] Reynolds, J.E.F. (ed.) (1993). Martindale: The extra pharmacopoeia (30th edition ed.). London: Pharmaceutical Press. p. 1310. ISBN 0-85369-300-5.

[2] ttp://www.patient.co.uk/medicine/naftidrofuryl

[3] ttp://www.der-arzneimittelbrief.de/Jahrgang2004/Ausgabe12Seite89.htm

[Katzberg-4] Katzberg HD, Khan AH, So YT (February 2010). "Assessment: Symptomatic treatment for muscle cramps (an evidence-based review): Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology". Neurology 74 (8): 691–6. doi:10.1212/WNL.0b013e3181d0ccca. PMID 20177124.

匿名

検索

案内

案内

naftidrofuryl