naftidrofuryl
出典: meddic
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/03 10:05:41」(JST)
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- 1. 下肢末梢動脈疾患の症状を治療するための試験的治療 investigational therapies for treating symptoms of lower extremity peripheral artery disease
- 2. 跛行のマネージメント management of claudication
- 3. 夜間の足痙攣 nocturnal leg cramps
- 4. 骨壊死症（無血管性骨壊死症） osteonecrosis avascular necrosis of bone
- 5. 患者情報：末梢動脈疾患および跛行（詳細） peripheral artery disease and claudication beyond the basics
英文文献
- Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor.
- Hao J, Chen B, Yao Y, Hossain M, Nagatomo T, Yao H, Kong L, Sun H.SourceState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Tianjin State Key Lab Modern Chinese Med, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2012 May 15;22(10):3441-4. Epub 2012 Apr 1.
- Naftidrofuryl oxalate (Praxilene®, 1) has been used for the treatment of intermittent claudication for more than 30years. It selectively blocks vascular and platelet 5-hydroxytryptamine 2 (5-HT(2)) receptors. This drug is marketed as a mixture of four stereoisomers, and so far there is no individua
- PMID 22516281
- Preventive aspects in peripheral artery disease.
- Aggarwal S, Loomba RS, Arora R.Source3333 Green Bay Road, North Chicago, IL-60064, USA.
- Therapeutic advances in cardiovascular disease.Ther Adv Cardiovasc Dis.2012 Apr;6(2):53-70. Epub 2012 Feb 15.
- The prevalence of peripheral artery disease is steadily increasing and is associated with significant morbidity, including a significant percentage of amputations. Peripheral artery disease often goes undiagnosed, making its prevention increasingly important. Patients with peripheral arterial diseas
- PMID 22337767
和文文献
- Assessment of Binding Affinity to 5-Hydroxytryptamine 2A (5-HT_<2A>) Receptor and Inverse Agonist Activity of Naftidrofuryl : Comparison With Those of Sarpogrelate
- Aly Saida Abdel Regal,Hossain Murad,Bhuiyan Mohiuddin Ahmed [他],NAKAMURA Takashi,NAGATOMO Takafumi
- Journal of pharmacological sciences 110(4), 445-450, 2009-08-20
- … Naftidrofuryl is a peripheral vasodilator that has been clinically used in the treatment of intermittent claudication and dementia. … The purpose of the present study is to assess the binding affinity and functional potency of naftidrofuryl to the 5-HT2A receptor, to find out the inverse agonist activity of this compound at a constitutively active mutant of 5-HT2A receptor, and finally to compare the findings with those of sarpogrelate. …
- NAID 10025738188
- 低酸素性致死に対するNaftidrofuryl Oxalateの延命作用
- 林 潤一 [他],佐藤 恭子,秋本 孝行,佐藤 秀昭,秦 葭哉
- 日本薬理学雑誌 99(4), 247-254, 1992
- … To analyze the effects of naftidrofuryl oxalate (LS-121) on the central nervous system exposed to critical hypoxia, survival duration was employed as a parameter of the protective effects of the drug against hypoxia-induced death. …
- NAID 130000758774
- Ischemia-Induced Changes in Brain Levels of Monoamines and Their Metabolites of Mice and Rats : Some Protective Effects of Naftidrofuryl
- NAKAMUTA Hiromichi,MUGURUMA Keiko,KOIDA Masao,HIRAMATSU Yasuzo,OGAWA Yasunao
- Journal of pharmacobio-dynamics 12(7), 429-436, 1989-07-00
- … Employing two types of brain ischemic animal models, an attempt was made to evaluate the protective effect of naftidrofuryl as the normalizing effect on the ischemia-induced changes in the brain levels of monoamines and metabolites. … Pretreatment with naftidrofuryl oxalate (45 mg/kg, i.p.) was found to prevent the DA change, but the lower dose (15 mg/kg, i.p.) of the drug or any other drug tested individually (vinpocetine hydrochloride : 2 mg/kg, Ca hopantenate : 0.1 g/kg, citicoline : 0.1 g/kg, i.p.) had no such effect. …
- NAID 110003663128
関連リンク
- Naftidrofuryl is used to treat Vascular disease (blood circulation problems). Naftidrofuryl works by widening blood vessels ... Before taking naftidrofuryl Some medicines are not suitable for people with certain conditions, and ...
- Naftidrofuryl is a medicine available in a number of countries worldwide. A list of US medications equivalent to Naftidrofuryl is available on the Drugs.com website. ... Drugs.com provides accurate and independent information on more ...
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■★リンクテーブル★
| リンク元 | 「ナフチドロフリル」 |
「ナフチドロフリル」
- 末梢性血管弛緩薬;5-HT2遮断薬
- 日本では発売されていない。
参考
- 1. wiki en
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