English Journal

Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA.

Soupene E1, Kao J2, Cheng DH2, Wang D2, Greninger AL3, Knudsen GM3, DeRisi JL4, Kuypers FA2.
Journal of lipid research.J Lipid Res.2015 Nov 30. pii: jlr.M065003. [Epub ahead of print]
The covalent attachment of a 14-carbon aliphatic tail on a glycine residue of nascent translated peptide chains is catalyzed in human cells by two N-myristoyltransferase (NMT) enzymes using the rare myristoyl-CoA (C14-CoA) molecule as fatty acid donor. Although, NMT enzymes can only transfer a myris
PMID 26621918

Dudek E1, Millott R1, Liu WX1, Beauchamp E2, Berthiaume LG2, Michalak M3.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Nov 19. pii: S0006-291X(15)30920-7. doi: 10.1016/j.bbrc.2015.11.052. [Epub ahead of print]
Calnexin is a type 1 integral endoplasmic reticulum (ER) membrane molecular chaperone with a highly conserved C-terminal domain oriented to the cytoplasm. Protein N-myristoylation plays an important role in a wide variety of cellular signal transduction pathways and it is catalyzed by N-myristoyltra
PMID 26603938

N-lauroylation during the expression of recombinant N-myristoylated proteins. Implications and solutions.

Flamm A1, Le Roux AL2, Mateos B3, Díaz-Lobo M4, Storch B5, Breuker K6, Konrat R7, Pons M8, Coudevylle N9.
Chembiochem : a European journal of chemical biology.Chembiochem.2015 Nov 2. doi: 10.1002/cbic.201500454. [Epub ahead of print]
Incorporation of myristic acid to the N-terminus of proteins is a crucial modification that promotes membrane binding and proper localization of important components of signaling pathways. Recombinant expression of N-myristoylatyed proteins in E. coli can be achieved by co-expressing yeast N-myristo
PMID 26522884

Japanese Journal

川原一芳カワハラカズヨシKAWAHARA Kazuyoshi,伊藤瑞穂イトウミズホITO Mizuho
研究報告 55(2), 63-70, 2012-03
… Lipid A structure of Escherichia coli mutants constructed by insertional mutation of myristoyltransferase(MSBB) gene and reintroduction of the gene were analyzed by Matrix Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry(MALDI-TOF MS). …
NAID 120005303527

Suppression of Human Immunodeficiency Virus Type-1 Production by Coexpression of Catalytic-Region-Deleted N-Myristoyltransferase Mutants

Takamune Nobutoki,Kuroe Tetsuya,Tanada Noriaki [他],Shoji Shozo,Misumi Shogo
Biological and Pharmaceutical Bulletin 33(12), 2018-2023, 2010
… N-Myristoyltransferase (NMT) isozymes, i.e., NMT1 and NMT2, are essential host factors for the AIDS-causing human immunodeficiency virus type-1 (HIV-1), by which the viral proteins Pr55gag and Nef are N-myristoylated. …
NAID 130000402337

3C11-4 ゼブラフィッシュ発生過程におけるMethionine aminopeptidaseおよびN-Myristoyltransferaseの発現解析(酵素学・酵素工学・タンパク質工学,その他,一般講演)