WordNet

the stalk of a stamen
a thin wire (usually tungsten) that is heated white hot by the passage of an electric current
a threadlike structure (as a chainlike series of cells) (同)filum
the commonest protein in muscle; a globulin that combines with actin to form actomyosin

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 拡張能障害の細胞学的機序 cellular mechanisms of diastolic dysfunction
2. 肥大型心筋症の遺伝学 genetics of hypertrophic cardiomyopathy
3. 心不全の病態生理：左心室の圧-容積とその他の血行動態の関係 pathophysiology of heart failure left ventricular pressure volume and other hemodynamic relationships
4. 運動生理学 exercise physiology
5. 心疾患関連する遺伝性症候群 inherited syndromes associated with cardiac disease

Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.

Huang W1, Liang J1, Kazmierczak K1, Muthu P1, Duggal D2, Farman GP3, Sorensen L4, Pozios I4, Abraham TP4, Moore JR3, Borejdo J2, Szczesna-Cordary D5.
Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2014 Sep;74:318-29. doi: 10.1016/j.yjmcc.2014.06.011. Epub 2014 Jun 30.
We have examined, for the first time, the effects of the familial hypertrophic cardiomyopathy (HCM)-associated Lys104Glu mutation in the myosin regulatory light chain (RLC). Transgenic mice expressing the Lys104Glu substitution (Tg-MUT) were generated and the results were compared to Tg-WT (wild-typ
PMID 24992035

Electrostatic forces or structural scaffolding: what stabilizes the lattice spacing of relaxed skinned muscle fibers?

Smith DA.
Journal of theoretical biology.J Theor Biol.2014 Aug 21;355:53-60. doi: 10.1016/j.jtbi.2014.03.037. Epub 2014 Apr 1.
The filament lattice in relaxed striated muscle is thought to be stabilized by electrostatic forces between charged filaments; electrostatic theories based on known filament charge densities do predict that the lattice spacing drops slightly with sarcomere length when actin and myosin filaments over
PMID 24703982

Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.

Nishikimi A1, Ishihara S1, Ozawa M2, Etoh K3, Fukuda M3, Kinashi T4, Katagiri K5.
Science signaling.Sci Signal.2014 Jul 29;7(336):ra72. doi: 10.1126/scisignal.2005199.
In lymphocytes, the kinase Mst1 is required for the proper organization of integrins in the plasma membrane at the leading edge of migrating cells, which is critical for lymphocyte trafficking. We found a functional link between the small G protein Rab13 and Mst1 in lymphocyte adhesion and migration
PMID 25074980

Podocyte Cell Biology Update:Understanding the Formation of Podocyte Structure in Health and Disease

KURIHARA HIDETAKE
順天堂醫事雑誌 60(2), 151-155, 2014
… Especially, regulation of actin filaments in foot processes is important for maintaining integrity of the cytoskeleton and organization of the slit diaphragm. …
NAID 130004684333

F-actin and a Type-II Myosin Are Required for Efficient Clustering of the ER Stress Sensor Ire1

Ishiwata-Kimata Yuki,Yamamoto Yo-hei,Takizawa Ken,Kohno Kenji,Kimata Yukio
Cell Structure and Function 38(2), 135-143, 2013
… Ire1 cluster formation was also impaired by deletion of the type-II myosin gene MYO1 or SAC6, which encodes the actin-bundling protein fimbrin. … Finally, we demonstrated that Ire1 clusters are predominantly located on or near actin filaments. … Therefore, we propose that actin filaments play an important role in ER stress-induced clustering of Ire1. …
NAID 130004053895